Cited by 4,173Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsGenomics and Chromatin Dynamics

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Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

Gerdes, J, Lemke, H, Baisch, H, Wacker, H H, Schwab, U, Stein, H·1984·The Journal of Immunology

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Abstract

The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. The aim of the present investigation was to clarify whether the Ki-67 nuclear antigen is restricted in its expression to certain phases of the cell cycle. All experiments consistently showed that the Ki-67 nuclear antigen is present in S, G2, and M phase, but is absent in G0. However, the results concerning Ki-67 antigen expression in G1 phase varied: cells passing the early events of mitogen triggered transition from G0 to G1, i.e., G1T and first G1A, lacked the Ki-67 nuclear antigen, whereas G1 cells after mitosis were constantly Ki-67-positive. This result suggests that after mitosis cells might not follow the same metabolic pathways as G0 cells do when entering G1 for the first time. Therefore, we suggest that the early stages of mitogen stimulation represent initial sequences of proliferation and not parts of the cell cycle. Because our data show that the Ki-67 nuclear antigen is present throughout the cell cycle, immunostaining with monoclonal antibody Ki-67 provides a reliable means of rapidly evaluating the growth fraction of normal and neoplastic human cell populations.

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Crossref · 10.4049/jimmunol.133.4.1710

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Self-citation
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Patel, A., Halliday, G. M., Cooke, B. E., & Barnetson, R. S. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb08580.x · Cited by 75
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Gerdes, J., Unnik, J. A. M. V., Pileri, S. A., Schwarting, R., Unnik, J. A. M. V., & Stein, H. (1987) · PubMed Central · Cited by 75
Self-citation
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Hentschel, S. J., McCutcheon, I. E., Moore, W., & Durity, F. A. (2003) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100002614 · Cited by 74
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Sueishi, M., Takagi, M., & Yoneda, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003879200 · Cited by 74
A Novel Nucleolar Protein, NIFK, Interacts with the Forkhead Associated Domain of Ki-67 Antigen in Mitosis
Takagi, M., Sueishi, M., Saiwaki, T., Kametaka, A., & Yoneda, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102227200 · Cited by 74
Cyclical endometrial steroid hormone receptor expression and proliferation intensity in the mare
Aupperle, H., Ozgen, S., Schoon, H., Schoon, D. V., Hoppen, H. ‐., Sieme, H., & Tannapfel, A. (2000) · Equine Veterinary Journal · doi:10.2746/042516400776563554 · Cited by 74
Low-Dose Mifepristone Inhibits Endometrial Proliferation and Up-Regulates Androgen Receptor
Narvekar, N. N., Cameron, S. T., Critchley, H., Lin, S., Cheng, L., & Baird, D. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031945 · Cited by 74
Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia
Staber, P. B., Linkesch, W., Zauner, D., Beham‐Schmid, C., Guelly, C., Schauer, S., Sill, H., & Höefler, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207192 · Cited by 74
Cell proliferation in non-Hodgkin's lymphomas. Digital image analysis of Ki-67 antibody staining.
Schwartz, B. R., Pinkus, G. S., Bacus, S. S., Toder, M., & Weinberg, D. S. (1989) · Europe PMC (PubMed Central) · Cited by 74
Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells.
Gore, S. D., Samid, D., & Weng, L. J. (1997) · PubMed · Cited by 74
A comparison of three methods for the determination of the growth fraction in non-Hodgkin's lymphoma
Schrape, S., Jones, D., & Wright, D. (1987) · British Journal of Cancer · doi:10.1038/bjc.1987.54 · Cited by 74
A niche of trophoblast progenitor cells identified by integrin α2 is present in first trimester human placentas
Lee, C. Q. E., Turco, M. Y., Gardner, L., Simons, B. D., Hemberger, M., & Moffett, A. (2018) · Development · doi:10.1242/dev.162305 · Cited by 78
Preventive and Therapeutic Euphol Treatment Attenuates Experimental Colitis in Mice
Dutra, R. C., Claudino, R. F., Bento, A. F., Marcon, R., Schmidt, É. C., Bouzon, Z. L., Pianowski, L. F., & Calixto, J. Β. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027122 · Cited by 74
MIB‐1 immunoreactivity correlates with biologic behaviour in canine cutaneous melanoma
Laprie, C., Abadie, J., Amardeilh, M. F., Net, J., Lagadic, M., & Delverdier, M. E. (2001) · Veterinary Dermatology · doi:10.1046/j.1365-3164.2001.00236.x · Cited by 73
Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain
Guerrero‐Cazares, H., González-Pérez, Ó., Soriano‐Navarro, M., Zamora-Berridi, G. J., García‐Verdugo, J. M., & Quiñones‐Hinojosa, A. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22566 · Cited by 71
Hippocampal Pyramidal Neurons Switch from a Multipolar Migration Mode to a Novel “Climbing” Migration Mode during Development
Kitazawa, A., Kubo, K., Hayashi, K., Matsunaga, Y., Ishii, K., & Nakajima, K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2254-13.2014 · Cited by 75
Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys
Hoivik, D. J., Qualls, C. W., Mirabile, R. C., Cariello, N. F., Kimbrough, C. L., Colton, H. M., Anderson, S. P., Santostefano, M. J., Morgan, R. J. O., Dahl, R. R., et al. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh182 · Cited by 73
Cell Cycle Regulation by Alternative Polyadenylation of CCND1
Wang, Q., He, G., Hou, M., Chen, L., Chen, S., Xu, A., & Fu, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-25141-0 · Cited by 72
Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer
Kriseman, M. L., Monsivais, D., Agno, J. E., Masand, R. P., Creighton, C. J., & Matzuk, M. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806862116 · Cited by 73
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Kaufman, A., Kim, J., Noel, C. A., & Dando, R. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0429-6 · Cited by 67
Histopathology and growth pattern of cystic acoustic neuromas
Charabi, S., Klinken, L., Tos, M., & Thomsen, J. (1994) · The Laryngoscope · doi:10.1288/00005537-199411000-00006 · Cited by 73
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McTiernan, A., Yasui, Y., Sorensen, B. E., Irwin, M. L., Morgan, A., Rudolph, R. E., Surawicz, C. M., Lampe, J. W., Ayub, K., Potter, J. D., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0223 · Cited by 73
Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.
Kreipe, H. H., Feist, H., Fischer, L., Felgner, J., Heidorn, K., Mettler, L., & Parwaresch, R. M. (1993) · PubMed · Cited by 73

Authors: Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U., & Stein, H.
Affiliations: Christian-Albrechts-Universität zu Kiel (DE)
Universität Hamburg (DE)
ORCID: Lemke, H
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1984-10-01
Volume: 133
Issue: 4
Pages: 1710-1715
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.133.4.1710
OpenAlex: W2126486896
Cited by: 4,173
References: 0
Citations by year: 2026: 44 · 2025: 65 · 2024: 90 · 2023: 70 · 2022: 83 · 2021: 105 · 2020: 76 · 2019: 98 · 2018: 93 · 2017: 127 · 2016: 111 · 2015: 114 · 2014: 112 · 2013: 122 · 2012: 101
FWCI: 14.15
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: Ki-67, cell proliferation, cell cycle, nuclear antigens, G0 to G1 transition, G1 phase, S phase, G2/M phase, mitogen stimulation, growth fraction, monoclonal antibodies, neoplastic cells
MeSH terms: Animals, Antibodies, Monoclonal, Blood Proteins, Cell Cycle, Cycloheximide, DNA, Humans, Kinetics, Lymphocyte Activation, Lymphocytes, Mitomycins, Nucleoproteins, Phytohemagglutinins, RNA, Mitomycin, Antigens, Nuclear, Mice

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Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

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