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Characterization of the beta-adrenergic receptor of the rat peritoneal macrophage.
Abstract
The beta-adrenergic receptor was characterized on BCG-activated rat peritoneal macrophage membranes by radio-ligand binding studies. Saturable binding with [125I]iodocyanopindolol (125I-ICYP) was demonstrated. With Scatchard analysis, rat macrophages demonstrate approximately 1000 receptors per cell with a Kd of 5 X 10(-11) M for 125I-ICYP. Competition curves with (-) and (+) propranolol at concentrations below 10(-6) M confirmed stereospecificity. The potency of various ligands to compete for 125I-ICYP binding sites followed the order: propranolol greater than isoproterenol greater than epinephrine greater than norepinephrine with apparent Kd of 2.0 X 10(-9), 3.9 X 10(-7), 1.0 X 10(-5), and 2.5 X 10(-5) M, respectively. Isoproterenol-stimulated adenylate cyclase activity was two-fold above basal activity. The potential physiologic significance of a beta-adrenergic receptor on rat peritoneal macrophages was suggested by a dose-dependent decrease in phagocytosis of soluble, model immune complexes (aggregated gamma-globulin) by macrophages incubated with metaproterenol. We conclude that the rat macrophage has a beta-adrenergic receptor and that catecholamines may thereby modulate macrophage function.
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Citations
Cited by
Noradrenergic Sympathetic Neural Interactions with the Immune System: Structure and Function
Felten, D. L., Felten, S. Y., Bellinger, D. L., Carlson, S. L., Ackerman, K. D., Madden, K. S., Olschowki, J. A., & Livnat, S. (1987) · Immunological Reviews · doi:10.1111/j.1600-065x.1987.tb00534.x · Cited by 746
Autonomic Nervous System and Immune System Interactions
Kenney, M. J., & Ganta, C. K. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130051 · Cited by 381
Cytokines and the central nervous system
Szelényi, J. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00428-2 · Cited by 358
Guéguinou, N., Huin-Schohn, C., Bascove, M., Bueb, J.-L., Tschirhart, E., Legrand-Frossi, C., & Frippiat, J.-P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309167 · Cited by 280
Sympathetic modulation of immunity: Relevance to disease
Bellinger, D. L., Millar, B. A., Perez, S., Carter, J., Wood, C., ThyagaRajan, S., Molinaro, C., Lubahn, C., & Lorton, D. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2007.09.005 · Cited by 254
Metadata
- Authors
- Abrass, C. K., O'Connor, S. W., Scarpace, P. J., & Abrass, I. B.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-08-01
- Volume
- 135
- Issue
- 2
- Pages
- 1338-1341
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1529606715
- Cited by
- 189
- References
- 0
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Abrass, C. K., O'Connor, S. W., Scarpace, P. J., & Abrass, I. B. (1985). Characterization of the beta-adrenergic receptor of the rat peritoneal macrophage. The Journal of Immunology. https://doi.org/10.4049/jimmunol.135.2.1338
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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