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Stress, opioid peptides, the immune system, and cancer
Abstract
Our results indicate that a particular form of foot-shock stress can suppress immune function in rats and decrease their resistance to tumor challenge. These effects appear to be mediated by opioid peptides released by stress, and they can be mimicked by high doses of morphine given systemically or by a vastly smaller dose delivered intracerebroventric-ularly. Such findings fit well into the emerging field of behavioral neuroimmunology and reinforce continuing efforts to elucidate the neural and neurohumoral mechanisms by which the environment can affect the organism’s immune system.
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Cited by
Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Benaroya‐Milshtein, N., Hollander, N., Apter, A., Kukulansky, T., Raz, N., Wilf, A., Yaniv, I., & Pick, C. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03587.x · Cited by 439
Garg, A., Chren, M.-M., Sands, L. P., Matsui, M. S., Marenus, K. D., Feingold, K. R., & Elias, P. M. (2001) · Archives of Dermatology · doi:10.1001/archderm.137.1.53 · Cited by 384
Opioid Guidelines in the Management of Chronic Non-Cancer Pain
Manchikanti, L. (2006) · Pain Physician · doi:10.36076/ppj.2006/9/2 · Cited by 277
Metadata
- Authors
- Shavit, Y., Terman, G. W., Martin, F. C., Lewis, J. W., Liebeskind, J. C., & Gale, R. P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-08-01
- Volume
- 135
- Issue
- 2
- Pages
- 834-837
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1601600442
- Cited by
- 187
- References
- 0
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Shavit, Y., Terman, G. W., Martin, F. C., Lewis, J. W., Liebeskind, J. C., & Gale, R. P. (1985). Stress, opioid peptides, the immune system, and cancer. The Journal of Immunology. https://doi.org/10.4049/jimmunol.135.2.834
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
