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Interleukin 1 is a radioprotector.
Abstract
Pretreatment with recombinant interleukin 1 (IL 1) protects mice in a dose-dependent manner from lethal effects of ionizing radiation. Two thousand units of IL 1, given i.p. 20 hr before irradiation, protect 88% of C57B1/6 mice from an LD100/17 radiation dose (dose of radiation that kills 100% mice in 17 days), and 1000 U of IL 1 protect 100% of DBA/1 mice from an LD50/30 dose. This finding provides the first evidence that a cytokine, IL 1, which acts as a differentiation- and maturation-inducing agent for a variety of cells, also can serve as a signal that initiates radioprotective events in vivo. Because many of the exogenous immunomodulators that have been shown to be radioprotective also induce endogenous IL 1 production, our observation suggests that IL 1 may mediate their radioprotective effects.
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The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions
Apte, R. N., Dotan, S., Elkabets, M., White, M. R., Reich, E., Carmi, Y., Song, X., Dvozkin, T., Krelin, Y., & Voronov, E. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9004-4 · Cited by 593
Metadata
- Authors
- Neta, R., Douches, S., & Oppenheim, J. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-04-01
- Volume
- 136
- Issue
- 7
- Pages
- 2483-2485
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1575925035
- Cited by
- 371
- References
- 0
- FWCI
- 28.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Neta, R., Douches, S., & Oppenheim, J. J. (1986). Interleukin 1 is a radioprotector. The Journal of Immunology. https://doi.org/10.4049/jimmunol.136.7.2483
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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