Cited by 914Redox biology and oxidative stressCell death mechanisms and regulationGlutathione Transferases and Polymorphisms

Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism

Wong, Grace H. W., Goeddel, David V.·1988·Science

Abstract

Manganous superoxide dismutase (MnSOD) scavenges potentially toxic superoxide radicals produced in the mitochondria. Tumor necrosis factor-alpha (TNF-alpha) was found to induce the messenger RNA for MnSOD, but not the mRNAs for other antioxidant or mitochondrial enzymes tested. The increase in MnSOD mRNA occurred rapidly and was blocked by actinomycin D, but not by cycloheximide. Induction of MnSOD mRNA was also observed with TNF-beta, interleukin-1 alpha (IL-1 alpha), and IL-1 beta but not with other cytokines or agents tested. TNF-alpha induced MnSOD mRNA in all cell lines and normal cells examined in vitro and in various organs of mice in vivo. These effects of TNF-alpha and IL-1 on target cells may contribute to their reported protective activity against radiation as well as their ability to induce resistance to cell killing induced by the combination of TNF-alpha and cycloheximide.

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Crossref · 10.1126/science.3263703

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Authors
Wong, G. H. W., & Goeddel, D. V.
Affiliations
Genentech (US)
Venue
Science
Published
1988-11-11
Volume
242
Issue
4880
Pages
941-944
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2051867686
Cited by
914
References
62
Citations by year
2026: 2 · 2025: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 3 · 2016: 12 · 2015: 5 · 2014: 11 · 2013: 11 · 2012: 15
FWCI
14.76
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Keywords
TNF-α, lymphotoxin, interleukin-1, antioxidant enzymes, mitochondrial superoxide, actinomycin D, radiation protection, cycloheximide
MeSH terms
Animals, Catalase, Cell Line, Cycloheximide, Dactinomycin, Enzyme Induction, Humans, Interleukin-1, Kinetics, Mitochondria, RNA, Messenger, Superoxide Dismutase, Tissue Distribution, Tumor Necrosis Factor-alpha, Mice, Rats

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