Cutting Edge: Vitamin D Regulates Lipid Metabolism in Mycobacterium tuberculosis Infection
Open accessAbstract
Vitamin D has long been linked to resistance to tuberculosis, an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces macrophage antimicrobial functions against Mycobacterium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated transcriptome and mechanistic studies. Transcriptome analysis revealed an association between vitamin D receptor (VDR) and lipid metabolism in human tuberculosis and infected macrophages. Vitamin D treatment of infected macrophages abrogated infection-induced accumulation of lipid droplets, which are required for intracellular M. tuberculosis growth. Additional transcriptomics results showed that vitamin D downregulates the proadipogenic peroxisome proliferator–activated receptor γ (PPARγ) in infected macrophages. PPARγ agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARγ signaling in regulating both vitamin D functions. These findings suggest the potential for host-based, adjunct antituberculosis therapy targeting lipid metabolism.
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By inhibiting PPARγ, vitamin D prevents M. tuberculosis-induced lipid droplet accumulation, which is essential for mycobacterial multiplication.
“By inhibiting peroxisome proliferator-activated receptor γ (PPARγ), vitamin D prevented M. tuberculosis-induced lipid droplet accumulation, which is essential for mycobacterial multiplication (87).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [87]
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Macrophage defense mechanisms against intracellular bacteria
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- Authors
- Salamon, H., Bruiners, N., Lakehal, K., Shi, L., Ravi, J., Yamaguchi, K. D., Pine, R., & Gennaro, M. L.
- Affiliations
- Berkeley City College (US)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Salamon, Hugh
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-07-01
- Volume
- 193
- Issue
- 1
- Pages
- 30-34
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC4073889
- OpenAlex
- W1898771364
- Cited by
- 99
- References
- 20
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 13 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 13 · 2014: 3
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- New Jersey Health Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL068517, HL68517, HL 106788, R01HL106788)
- National Institute of Allergy and Infectious Diseases (AI-090328, R01AI037877, R21AI090328)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- vitamin D, Mycobacterium tuberculosis, tuberculosis, lipid metabolism, vitamin D receptor, PPARγ, lipid droplets, macrophages, host-directed therapy, antimicrobial resistance, transcriptome
- MeSH terms
- Humans, Mycobacterium tuberculosis, Tuberculosis, Vitamin D, Vitamins, Receptors, Calcitriol, Cell Line, Tumor, PPAR gamma, Lipid Metabolism, Transcriptome
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