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Cited by 129T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesLymphatic System and Diseases

Fibroblastic Reticular Cells: Organization and Regulation of the T Lymphocyte Life Cycle

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Brown, Flavian D, Turley, Shannon J·2015·The Journal of Immunology
DOI 10.4049/jimmunol.1402520PMC PMC4324549
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Abstract

The connective tissue of any organ in the body is generally referred to as stroma. This complex network is commonly composed of leukocytes, extracellular matrix components, mesenchymal cells, and a collection of nerves, blood, and lymphoid vessels. Once viewed primarily as a structural entity, stromal cells of mesenchymal origin are now being intensely examined for their ability to directly regulate various components of immune cell function. There is particular interest in the ability of stromal cells to influence the homeostasis, activation, and proliferation of T lymphocytes. One example of this regulation occurs in the lymph node, where fibroblastic reticular cells support the maintenance of naive T cells, induce Ag-specific tolerance, and restrict the expansion of newly activated T cells. In an effort to highlight the varied immunoregulatory properties of fibroblastic reticular cells, we reviewed the most recent advances in this field and provide some insights into potential future directions.

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  • Fibroblastic reticular cells within lymph nodes generate ECM conduits for transit of potential antigens and serve as migration highways for leukocytes, allowing effective immune surveillance.

    “fibroblastic reticular cells (FRCs) within lymph nodes generate ECM conduits for the transit of potential antigens and serve as migration ‘highways’ for leukocytes21. This allows effective immune surveillance.”

    From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [21]

  • The function of FRCs in lymph nodes is to make possible an effective T cell-mediated immune response.

    “the function of FRCs in lymph nodes is to make possible an effective T cell-mediated immune response21.”

    From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [21]

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Authors
Brown, F. D., & Turley, S. J.
Affiliations
  • Harvard University (US)
  • Genentech (US)
Corresponding author
Turley, Shannon J
ORCID
Turley, Shannon J
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2015-02
Volume
194
Issue
4
Pages
1389-1394
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.1402520
PMC
PMC4324549
OpenAlex
W1917974963
Cited by
129
References
5
Citations by year
2026: 6 · 2025: 10 · 2024: 11 · 2023: 14 · 2022: 14 · 2021: 15 · 2020: 12 · 2019: 15 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 5
FWCI
1.00
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Allergy and Infectious Diseases (P01AI045757)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074500)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords
fibroblastic reticular cells, lymph node stroma, naive T cells, antigen-specific tolerance, T cell homeostasis, T cell activation, T cell proliferation, immune regulation, mesenchymal stem cells
MeSH terms
Animals, Humans, Lymph Nodes, Lymphocyte Activation, T-Lymphocytes, Stromal Cells

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