Transcriptional control of effector and memory CD8+ T cell differentiation

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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T cell exhaustion

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

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Lineage relationship and protective immunity of memory CD8 T cell subsets

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Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · see citing works

Immunological memory and protective immunity: understanding their relation

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

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mTOR regulates memory CD8 T-cell differentiation

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.006 · Cited by 1,355 · see citing works

mTOR differentially regulates effector and regulatory T cell lineage commitment

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

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Homeostasis of Naive and Memory T Cells

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JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

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Molecular and functional profiling of memory CD8 T cell differentiation.

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Regulation and function of mTOR signalling in T cell fate decisions

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Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

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Redefining Chronic Viral Infection

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Function of Mitochondrial Stat3 in Cellular Respiration

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Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

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ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

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Effector and Memory CTL Differentiation

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Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883 · see citing works

Memory CD8 T-Cell Differentiation during Viral Infection

Wherry, E. J., & Ahmed, R. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5535-5545.2004 · Cited by 858 · see citing works

Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

Chang, J. T., Palanivel, V., Kinjyo, I., Schambach, F., Intlekofer, A. M., Banerjee, A., Longworth, S. A., Vinup, K. E., Mrass, P., Oliaro, J., et al. (2007) · Science · doi:10.1126/science.1139393 · Cited by 845 · see citing works

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Pipkin, M. E., Sacks, J. A., Cruz‐Guilloty, F., Lichtenheld, M. G., Bevan, M. J., & Rao, A. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.012 · Cited by 799 · see citing works

CD27 is required for generation and long-term maintenance of T cell immunity

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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C., & Levy, D. E. (2009) · Science · doi:10.1126/science.1171721 · Cited by 716 · see citing works

Complete but curtailed T-cell response to very low-affinity antigen

Zehn, D., Lee, S. Y., & Bevan, M. J. (2009) · Nature · doi:10.1038/nature07657 · Cited by 697 · see citing works

Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1

Zhou, X.-Y., Yu, S.-Y., Zhao, D.-M., Harty, J., Badovinac, V., & Xue, H.-H. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.002 · Cited by 689 · see citing works

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

Rao, R. R., Li, Q., Odunsi, K., & Shrikant, P. A. (2010) · Immunity · doi:10.1016/j.immuni.2009.10.010 · Cited by 656 · see citing works

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

Teijaro, J. R., Turner, D., Pham, Q., Wherry, E. J., Lefrançois, L., & Farber, D. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102243 · Cited by 641 · see citing works

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

Sarkar, S., Kalia, V., Haining, W. N., Konieczny, B. T., Subramaniam, S., & Ahmed, R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071641 · Cited by 633 · see citing works

Dynamic T cell migration program provides resident memory within intestinal epithelium

Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090858 · Cited by 628 · see citing works

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

Kaech, S. M., & Wherry, E. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.007 · Cited by 619 · see citing works

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

Rutishauser, R. L., Martins, G. A., Kalachikov, S. M., Chandele, A., Parish, I. A., Meffre, E., Jacob, J., Calame, K. L., & Kaech, S. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.014 · Cited by 612 · see citing works

Signals required for programming effector and memory development by CD8+ T cells

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Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

Kalia, V., Sarkar, S., Subramaniam, S., Haining, W. N., Smith, K. A., & Ahmed, R. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.010 · Cited by 590 · see citing works

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

Yang, X.-P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H.-W., Wei, L., Vahedi, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.1995 · Cited by 583 · see citing works

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

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Different patterns of peripheral migration by memory CD4+ and CD8+ T cells

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Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

Crotty, S., Johnston, R. J., & Schoenberger, S. P. (2010) · Nature Immunology · doi:10.1038/ni.1837 · Cited by 525 · see citing works

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

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Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

Quigley, M. M., Pereyra, F., Nilsson, B., Porichis, F., Fonseca, C., Eichbaum, Q. G., Jülg, B. D., Jesneck, J. L., Brosnahan, K., Imam, S., et al. (2010) · Nature Medicine · doi:10.1038/nm.2232 · Cited by 505 · see citing works

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

Kallies, A., Xin, A., Belz, G. T., & Nutt, S. L. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.021 · Cited by 505 · see citing works

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

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Progressive differentiation and selection of the fittest in the immune response

Lanzavecchia, A., & Sallusto, F. (2002) · Nature Reviews Immunology · doi:10.1038/nri959 · Cited by 495 · see citing works

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

Kao, C., Oestreich, K. J., Paley, M., Crawford, A., Angelosanto, J., Ali, M.-A. A., Intlekofer, A. M., Boss, J. M., Reiner, S. L., Weinmann, A. S., et al. (2011) · Nature Immunology · doi:10.1038/ni.2046 · Cited by 484 · see citing works

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

Shin, H., Blackburn, S. D., Intlekofer, A. M., Kao, C., Angelosanto, J., Reiner, S. L., & Wherry, E. J. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.019 · Cited by 481 · see citing works

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

Marzo, A. L., Klonowski, K. D., Bon, A. L., Borrow, P., Tough, D. F., & Lefrançois, L. (2005) · Nature Immunology · doi:10.1038/ni1227 · Cited by 465 · see citing works

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

Banerjee, A., Gordon, S. M., Intlekofer, A. M., Paley, M., Mooney, E. C., Lindsten, T., Wherry, E. J., & Reiner, S. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002042 · Cited by 429 · see citing works

Foxo Transcription Factors Control Regulatory T Cell Development and Function

Kerdiles, Y. M., Stone, E. L., Beisner, D. R., McGargill, M. A., Ch’en, I. L., Stockmann, C., Katayama, C. D., & Hedrick, S. Μ. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.002 · Cited by 419 · see citing works

The Alarmin Interleukin-33 Drives Protective Antiviral CD8 + T Cell Responses

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Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

Pepper, M., Pagán, A. J., Igyártó, B. Z., Taylor, J. J., & Jenkins, M. K. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.009 · Cited by 412 · see citing works

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets

Yang, C. Y., Best, J. A., Knell, J., Yang, E., Sheridan, A. D., Jesionek, A. K., Li, H. S., Rivera, R. R., Lind, K. C., D’Cruz, L. M., et al. (2011) · Nature Immunology · doi:10.1038/ni.2158 · Cited by 411 · see citing works

An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells

Cui, W., Liu, Y., Weinstein, J. S., Craft, J., & Kaech, S. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.017 · Cited by 410 · see citing works

Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

Badovinac, V. P., Messingham, K. N., Jabbari, A., Haring, J. S., & Harty, J. T. (2005) · Nature Medicine · doi:10.1038/nm1257 · Cited by 403 · see citing works

A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets.

Stemberger, C., Huster, K., Koffler, M., Anderl, F., Schiemann, M., Wagner, H., & Busch, D. (2007) · Immunity · doi:10.1016/j.immuni.2007.10.012 · Cited by 394 · see citing works

Anomalous Type 17 Response to Viral Infection by CD8 + T Cells Lacking T-bet and Eomesodermin

Intlekofer, A. M., Banerjee, A., Takemoto, N., Gordon, S. M., DeJong, C. S., Shin, H., Hunter, C. A., Wherry, E. J., Lindsten, T., & Reiner, S. L. (2008) · Science · doi:10.1126/science.1159806 · Cited by 394 · see citing works

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Sinclair, L. V., Finlay, D. K., Feijóo, C. G., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H., & Cantrell, D. A. (2008) · Nature Immunology · doi:10.1038/ni.1603 · Cited by 391 · see citing works

Diversity in T Cell Memory: An Embarrassment of Riches

Jameson, S. C., & Masopust, D. (2009) · Immunity · doi:10.1016/j.immuni.2009.11.007 · Cited by 382 · see citing works

Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T Cells

Mazo, I. B., Honczarenko, M., Leung, H. C. H., Cavanagh, L. L., Bonasio, R., Weninger, W., Engelke, K., Xia, L., McEver, R. P., Koni, P. A., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.008 · Cited by 376 · see citing works

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

Jeannet, G., Boudousquié, C., Gardiol, N., Kang, J., Huelsken, J., & Held, W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914127107 · Cited by 360 · see citing works

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

Kwon, H., Thierry‐Mieg, D., Thierry‐Mieg, J., Kim, H., Oh, J., Tunyaplin, C., Carotta, S., Donovan, C. E., Goldman, M. L., Tailor, P. B., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.008 · Cited by 357 · see citing works

Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation

Takemoto, N., Intlekofer, A. M., Northrup, J. T., Wherry, E. J., & Reiner, S. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7515 · Cited by 339 · see citing works

Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection

Whitmire, J. K., Tan, J. T., & Whitton, J. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041463 · Cited by 332 · see citing works

CD4 Effector T Cell Subsets in the Response to Influenza

Román, E., Miller, E., Harmsen, A. G., Wiley, J., von Andrian, U. H., Huston, G. E., & Swain, S. L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021052 · Cited by 327 · see citing works

CD8+ T cell contraction is controlled by early inflammation

Badovinac, V. P., Porter, B. B., & Harty, J. T. (2004) · Nature Immunology · doi:10.1038/ni1098 · Cited by 317 · see citing works

Metabolism in T cell activation and differentiation

Pearce, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.018 · Cited by 314 · see citing works

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

Oestreich, K. J., Mohn, S. E., & Weinmann, A. S. (2012) · Nature Immunology · doi:10.1038/ni.2242 · Cited by 314 · see citing works

Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-Boost Vaccination

Masopust, D., Ha, S., Vezys, V., & Ahmed, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.831 · Cited by 313 · see citing works

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

Marshall, H. D., Chandele, A., Jung, Y. W., Meng, H., Poholek, A. C., Parish, I. A., Rutishauser, R. L., Cui, W., Kleinstein, S. H., Craft, J. E., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.016 · Cited by 299 · see citing works

Human CD8+ T-cell differentiation in response to viruses

van Lier, R. A. W., ten Berge, I. J. M., & Gamadia, L. E. (2003) · Nature Reviews Immunology · doi:10.1038/nri1254 · Cited by 297 · see citing works

Genomic views of STAT function in CD4+ T helper cell differentiation

O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295 · see citing works

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation

Rao, R. R., Li, Q., Bupp, M. G., & Shrikant, P. A. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.015 · Cited by 293 · see citing works

The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

Weng, N.-P., Araki, Y., & Subedi, K. (2012) · Nature Reviews Immunology · doi:10.1038/nri3173 · Cited by 290 · see citing works

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

Intlekofer, A. M., Takemoto, N., Kao, C., Banerjee, A., Schambach, F., Northrop, J. K., Shen, H., Wherry, E. J., & Reiner, S. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070841 · Cited by 288 · see citing works

CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

Curtsinger, J., Johnson, C. M., & Mescher, M. F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5165 · Cited by 287 · see citing works

Regional and mucosal memory T cells

Sheridan, B., & Lefrançois, L. (2011) · Nature Immunology · doi:10.1038/ni.2029 · Cited by 281 · see citing works

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

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Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation1

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