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Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium.
Abstract
A panel of murine mAb specific for the chicken homologues of the CD3, CD4, CD8, TCR gamma delta, and TCR alpha beta has been used to study the distribution of T cells expressing these markers in sections of chicken lymphoid tissues. These studies have revealed that the T cells possessing the two classes of TCR occupy distinct histologic microenvironments. The TCR1+ cells (gamma delta TCR homologue) are localized preferentially in the splenic sinusoids and the intestinal epithelium, where most of them express the CD8 homologue. The TCR2+ cells (alpha beta TCR homologue), a majority of which express the CD4 homologue, are found primarily in the splenic periarteriolar sheath and the lamina propria of the intestine. The frequency and distribution of the two classes of T cells in the thymus is also unique. The different tissue homing patterns of the TCR1 and TCR2 cells suggest that they represent separate lineages of T cells with distinctive physiologic roles.
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Citations
Cited by
Six-of-the-best: unique contributions of γδ T cells to immunology
Vantourout, P., & Hayday, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3384 · Cited by 1,232
Allen, P. C., & Fetterer, R. H. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.1.58-65.2002 · Cited by 513
Intraepithelial lymphocytes: exploring the Third Way in immunology
Hayday, A., Theodoridis, E., Ramsburg, E., & Shires, J. (2001) · Nature Immunology · doi:10.1038/ni1101-997 · Cited by 491
Intestinal intraepithelial lymphocytes
Cerf-Bensussan, N., & Guy-Grand, D. (1991) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00570-7 · Cited by 144
Metadata
- Authors
- Bucy, R. P., Chen, C. L., Cihak, J., Lösch, U., & Cooper, M. D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-10-01
- Volume
- 141
- Issue
- 7
- Pages
- 2200-2205
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1558434765
- Cited by
- 232
- References
- 0
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium. https://app.cochat.ai/papers/10.4049/jimmunol.141.7.2200
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- Bucy, R. P., Chen, C. L., Cihak, J., Lösch, U., & Cooper, M. D. (1988). Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium. The Journal of Immunology. https://doi.org/10.4049/jimmunol.141.7.2200
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