Cited by 233Pancreatic function and diabetesDiabetes and associated disordersEndoplasmic Reticulum Stress and Disease

The DOI matches its Crossref record.

IFN- gamma and tumor necrosis factor- alpha . Cytotoxicity to murine islets of Langerhans.

Campbell, I L, Iscaro, A, Harrison, L C·1988·The Journal of Immunology

Open this paper in CoChat — free account

Abstract

We have previously reported that the cytokines IFN-gamma and TNF-alpha each upregulate the expression of class I MHC proteins and, in combination, induce the expression of class II MHC proteins on pancreatic islet cells. IFN-gamma and TNF-alpha are therefore implicated in the immunologic destruction of beta-cells in insulin-dependent diabetes mellitus. The objective of the present study was to define the effects of IFN-gamma and TNF-alpha on the function and viability of murine pancreatic islet beta-cells in vitro. Exposure of islets for 3 days to 200 U/ml of either IFN-gamma or TNF-alpha did not affect glucose-stimulated insulin release, but at higher concentrations (2000 U/ml) of either cytokine there was significant inhibition of glucose-stimulated insulin release. In combination, IFN-gamma and TNF-alpha each at 200 U/ml caused significant inhibition of glucose-stimulated insulin release; at 2000 U/ml glucose-stimulated insulin release was abolished. In time-course experiments, glucose-stimulated insulin release from islets exposed to IFN-gamma and TNF-alpha each at 1000 U/ml was significantly increased at 4-h (twofold increase compared with control islets), decreased back to control levels at 18 h, significantly inhibited by 24 h (threefold decrease compared with control islets), and completely abolished by 48 h. The progressive impairment of beta-cell function mediated by IFN-gamma plus TNF-alpha was associated with morphologic derangement of the islets that were almost totally disintegrated by day 6 of exposure to the cytokines. At day 6, insulin content of the islets was significantly reduced by exposure to TNF-alpha but not IFN-gamma. The combination of IFN-gamma and TNF-alpha resulted in a further dose-dependent depletion in insulin content compared with TNF-alpha alone. The synergistic functional and cytotoxic effects of IFN-gamma and TNF-alpha are consistent with a direct role for these cytokines in the destruction of beta-cells in insulin-dependent diabetes.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.141.7.2325

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Still being checked.

Sorted by citations

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis
Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P. A., & Drucker, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209423200 · Cited by 589
The role of interleukin-1 in the pathogenesis of IDDM
Mandrup-Poulsen, T. R. (1996) · Diabetologia · doi:10.1007/bf00400649 · Cited by 537
Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control
Lee, Y.-S., & Jun, H.-S. (2016) · Mediators of Inflammation · doi:10.1155/2016/3094642 · Cited by 530
The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles
Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Beyer, W. F., Hallewell, R. A., & Tainer, J. A. (1992) · Cell · doi:10.1016/0092-8674(92)90270-m · Cited by 472
Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.
Campbell, I. L., Kay, T. W. H., Oxbrow, L., & Harrison, L. C. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115055 · Cited by 371
Self-citation
Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ
Sarvetnick, N., Shizuru, J. A., Liggitt, D., Martin, L., Mclntyre, B., Gregory, A. K., Parslow, T. G., & Stewart, T. A. (1990) · Nature · doi:10.1038/346844a0 · Cited by 334
Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.
Yang, X., Tisch, R., Singer, S. M., Cao, Z. A., Liblau, R., Schreiber, R. D., & McDevitt, H. O. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.995 · Cited by 302
Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling
Cope, A. P., Liblau, R. S., Yang, X.-D., Congia, M., Laudanna, C., Schreiber, R. D., Probert, L., Kollias, G., & McDevitt, H. O. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1573 · Cited by 287
Etanercept Treatment in Children With New-Onset Type 1 Diabetes
Mastrandrea, L. D., Yu, J., Behrens, T., Buchlis, J. G., Albini, C. H., Fourtner, S. H., & Quattrin, T. (2009) · Diabetes Care · doi:10.2337/dc09-0054 · Cited by 280
Macrophage‐induced cytotoxicity of N‐methyl‐D‐aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines
Piani, D., Spranger, M., Frei, K., Schaffner, A., & Fontana, A. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220936 · Cited by 259
Prevention of diabetes in NOD mice treated with antibody to murine IFNγ
Debray-Sachs, M., Carnaud, C., Boîtard, C., Cohen, H., Gresser, I., Bédossa, P., & Bach, J. (1991) · Journal of Autoimmunity · doi:10.1016/0896-8411(91)90021-4 · Cited by 258
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
MUIR, A. B., Peck, A. B., Clare-Salzler, M. J., Song, Y., Cornelius, J., Luchetta, R., Krischer, J. P., & Maclaren, N. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117707 · Cited by 244
Poly-L-Lysine Induces Fibrosis on Alginate Microcapsules via the Induction of Cytokines
Strand, B. L., Ryan, L., Veld, P. I. '., Kulseng, B. E., Rokstad, A. M., Skjåk‐Bræk, G., & Espevik, T. (2001) · Cell Transplantation · doi:10.3727/000000001783986800 · Cited by 239
Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice
Kägi, D., Odermatt, B., Seiler, P. J., Zinkernagel, R. M., Mak, T. W., & Hengartner, H. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.989 · Cited by 235
IFN-γ/TNF-α Synergism as the Final Effector in Autoimmune Diabetes: A Key Role for STAT1/IFN Regulatory Factor-1 Pathway in Pancreatic β Cell Death
Suk, K., Kim, S., Kim, Y., Kim, K., Chang, I., Yagita∥, H., Shong, M., & Lee, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4481 · Cited by 222
Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus
Suresh, Y., & Das, U. N. (2003) · Nutrition · doi:10.1016/s0899-9007(02)00855-9 · Cited by 187
Cytokines and Free Radicals as Effector Molecules in the Destruction of Pancreatic Beta Cells
Mandrup-Poulsen, T. R., Helqvist, S., Wogensen, L., Mølvig, J., Pociot, F., Johannesen, J., & Nerup, J. (1990) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-75741-9_9 · Cited by 184
Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.
Satoh, J., Seino, H., Abo, T., Tanaka, S., Shintani, S., Ohta, S., Tamura, K., Sawai, T., Nobunaga, T., & Oteki, T. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114304 · Cited by 180
Tumor necrosis factor-alpha alters bovine luteal cell synthetic capacity and viability
Benyo, D. F., & Pate, J. L. (1992) · Endocrinology · doi:10.1210/en.130.2.854 · Cited by 179
Obesity and diabetes in TNF-alpha receptor- deficient mice.
Schreyer, S. A., Chua, S. C., & LeBoeuf, R. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2849 · Cited by 171
Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.
Mowat, A. M. (1989) · PubMed Central · Cited by 170
Ursolic acid enhances the cellular immune system and pancreatic β-cell function in streptozotocin-induced diabetic mice fed a high-fat diet
Jang, S.-M., Yee, S., Choi, J., Choi, M., Do, G., Jeon, S.-M., Yeo, J., Kim, M., Seo, K., & Lee, M. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.013 · Cited by 167
Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production
Rabinovitch, A., Suarez‐Pinzon, W. L., Strynadka, K. D., Lakey, J. R. T., & Rajotte, R. V. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784069 · Cited by 167
Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids
Mohan, I. K., & Das, U. N. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00468-8 · Cited by 163
Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.
Higuchi, Y., Herrera, P. L., Muniesa, P., Huarte, J., Belin, D., Ohashi, P. S., Aichele, P., Orci, L., Vassalli, J. D., & VASSALLI, P. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1719 · Cited by 151
Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.
Endl, J., Otto, H., Jung, G., Dreisbusch, B., Donié, F., Stahl, P., Elbracht, R., Schmitz, G., Meinl, E., Hummel, M., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119423 · Cited by 146
Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells
Deem, R. L., Shanahan, F., & Targan, S. R. (1991) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1991.tb05592.x · Cited by 146
Oxygen free radical scavengers protect rat islet cells from damage by cytokines
SUMOSKI, W., Baquerizo, H., & Rabinovitch, A. (1989) · Diabetologia · doi:10.1007/bf00264909 · Cited by 144
Why Do Cultured Transplanted Myoblasts Die in Vivo? DNA Quantification Shows Enhanced Survival of Donor Male Myoblasts in Host Mice Depleted of CD4 + and CD8 + Cells or NK1.1 + Cells
Hodgetts, S. I., Beilharz, M. W., Scalzo, A. A., & Grounds, M. D. (2000) · Cell Transplantation · doi:10.1177/096368970000900406 · Cited by 140
Cytotoxic effects of cytokines on rat islets: Evidence for involvement of free radicals and lipid peroxidation
Rabinovitch, A., Suarez‐Pinzon, W. L., Thomas, P. D., Strynadka, K. D., & Simpson, I. J. (1992) · Diabetologia · doi:10.1007/bf02342435 · Cited by 140
Microencapsulated islet grafts in the BB/E rat: a possible role for cytokines in graft failure
Cole, D. R., Waterfall, M., McIntyre, M., & BAIRD, J. D. (1992) · Diabetologia · doi:10.1007/bf00400922 · Cited by 140
Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression
O’Reilly, L., Hutchings, P. R., Crocker, P. R., Simpson, E., Lund, T., Kioussis, D., Takei, F., BAIRD, J. D., & Cooke, A. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210512 · Cited by 133
Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2
Iwahashi, H., Hanafusa, T., Eguchi, Y., Nakajima, H., Miyagawa, J.-I., Itoh, N., Tomita, K., Namba, M., Kuwajima, M., Noguchi, T., et al. (1996) · Diabetologia · doi:10.1007/bf00403299 · Cited by 132
Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGFβ
Merrill, J. E., & Zimmerman, R. (1991) · Glia · doi:10.1002/glia.440040311 · Cited by 121
NF-κB prevents β cell death and autoimmune diabetes in NOD mice
Kim, S., Millet, I., Kim, H. S., Kim, J., Han, M. S., Lee, M., Kim, K., Sherwin, R. S., Karin, M., & Lee, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610690104 · Cited by 119
12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets
Ma, K., Nunemaker, C. S., Wu, R. P., Chakrabarti, S. K., Taylor, D., & Nadler, J. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1102 · Cited by 112
Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus
Suresh, Y., & Das, U. N. (2003) · Nutrition · doi:10.1016/s0899-9007(02)00856-0 · Cited by 113
Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.
Seewaldt, S., Thomas, H. E., Ejrnaes, M., Christen, U., Wolfe, T., Rodrigo, E., Coon, B., Michelsen, B. K., Kay, T. W. H., & von Herrath, M. G. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1801 · Cited by 112
Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets
Jang, J. Y., Lee, D. Y., Park, S. J., & Byun, Y. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.10.062 · Cited by 111
Influence of Castration, Alone or Combined with Thymectomy, on the Development of Diabetes in the Nonobese Diabetic Mouse*
Fitzpatrick, F. T. A., Lepault, F., Homo‐Delarche, F., BACH, J.-F., & Dardenne, M. (1991) · Endocrinology · doi:10.1210/endo-129-3-1382 · Cited by 111
Significant Role for Fas in the Pathogenesis of Autoimmune Diabetes
Su, X., Hu, Q., Kristan, J., Costa, C., Shen, Y. M., Gerő, D., Matis, L. A., & Wang, Y. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2523 · Cited by 107
Tumor Necrosis Factor α Production by Peripheral Blood Mononuclear Cells of Patients With Chronic Liver Disease
Yoshioka, K., Kakumu, S., Arao, M., Tsutsumi, Y., & Inoue, M. (1989) · Hepatology · doi:10.1002/hep.1840100504 · Cited by 105
Low CD86 Expression in the Nonobese Diabetic Mouse Results in the Impairment of Both T Cell Activation and CTLA-4 Up-Regulation
Dahlén, E., Hedlund, G., & Dawe, K. I. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2444 · Cited by 104
Current Awareness
Roth, J. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200007/08)16:4
Synergistic activation of JNK/SAPK induced by TNF-α and IFN-γ: Apoptosis of pancreatic β-cells via the p53 and ROS pathway
Kim, W., Lee, J. W., Gao, B., & Jung, M. H. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.020 · Cited by 103
The central role of calcium in the effects of cytokines on beta-cell function: Implications for type 1 and type 2 diabetes
Ramadan, J. W., Steiner, S. R., O’Neill, C. M., & Nunemaker, C. S. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.08.005 · Cited by 104
TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.
Kägi, D., Ho, A., Odermatt, B., Zakarian, A., Ohashi, P. S., & Mak, T. W. (1999) · PubMed · Cited by 97
Alginate polylysine microcapsules as immune barrier: Permeability of cytokines and immunoglobulins over the capsule membrane
Kulseng, B. E. (1997) · Cell Transplantation · doi:10.1016/s0963-6897(97)00002-x · Cited by 94
Cytokine mRNA expression in the mucosa of treated coeliac patients after wheat peptide challenge.
Kontakou, M., Przemioslo, R. T., Sturgess, R. P., Limb, G. A., Ellis, H. J., Day, P., & Ciclitira, P. J. (1995) · Gut · doi:10.1136/gut.37.1.52 · Cited by 93
Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection.
Campbell, I. L., Cutri, A., Wilkinson, D. M., Boyd, A., & Harrison, L. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4282 · Cited by 89
Self-citation
Imbalanced Intrahepatic Cytokine Expression of Interferon-γ, Tumor Necrosis Factor-α, and Interleukin-10 in Patients With Acute-on-Chronic Liver Failure Associated With Hepatitis B Virus Infection
Zou, Z., Li, B., Xu, D., Zhang, Z., Zhao, J., Zhou, G., Sun, Y., Huang, L., Fu, J., Yang, Y., et al. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181624464 · Cited by 90
Expression of multiple forms of IL-1 receptor antagonist (IL-1ra) by human retinal pigment epithelial cells: identification of a new IL-1ra exon
Holtkamp, G. M., de Vos, A. F., Kijlstra, A., & Peek, R. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199901)29:01 · Cited by 31
Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling
Dula, S. B., Jecmenica, M., Wu, R., Jahanshahi, P., Verrilli, G. M., Carter, J. D., Brayman, K. L., & Nunemaker, C. S. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.07.007 · Cited by 83
Peroxynitrite Is a Mediator of Cytokine-Induced Destruction of Human Pancreatic Islet β Cells
Lakey, J. R. T., Suarez‐Pinzon, W. L., Strynadka, K., Korbutt, G. S., Rajotte, R. V., Mabley, J. G., Szabó, C., & Rabinovitch, A. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780381 · Cited by 83
Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice.
Campbell, I. L., Hobbs, M. V., Dockter, J., Oldstone, M. B. A., & Allison, J. (1994) · PubMed Central · Cited by 83
Self-citation
Immune Therapy and β-Cell Death in Type 1 Diabetes
Lebastchi, J., Deng, S., Lebastchi, A. H., Beshar, I., Gitelman, S. E., Willi, S. M., Gottlieb, P. A., Akirav, E. M., Bluestone, J. A., & Herold, K. C. (2013) · Diabetes · doi:10.2337/db12-1207 · Cited by 84
Role of Calcium in Pancreatic Islet Cell Death by IFN-γ/TNF-α
Chang, I., Cho, N., Kim, S., Kim, J. Y., Kim, E., Woo, J.-E., Nam, J. H., Kim, S. J., & Lee, M.-S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.7008 · Cited by 81
TNF Receptor 1-Dependent β Cell Toxicity as an Effector Pathway in Autoimmune Diabetes
Kägi, D., Ho, A., Odermatt, B., Zakarian, A., Ohashi, P. S., & Mak, T. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4598 · Cited by 103
Intensity of the Vaccine-Elicited Immune Response Determines Tumor Clearance
Pérez‐Díez, A., Spiess, P. J., Restifo, N. P., Matzinger, P., & Marincola, F. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.338 · Cited by 81
Cytokines as Immune Effector Molecules in Autoimmune Endocrine Diseases with Special Reference to Insulin-Dependent Diabetes Mellitus
Mandrup-Poulsen, T. R., Helqvist, S., Mølvig, J., Wogensen, L., & Nerup, J. (1989) · Autoimmunity · doi:10.3109/08916938909003049 · Cited by 78
Modulation of Bovine Luteal Cell Synthetic Capacity by Interferon-γ1
Fairchild, D. L., & Pate, J. L. (1991) · Biology of Reproduction · doi:10.1095/biolreprod44.2.357 · Cited by 80
TNF‐α inhibits glucose‐induced insulin secretion in a pancreatic β‐cell line (INS‐1)
Zhang, S., & Kim, K.-H. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01272-9 · Cited by 78
Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic β-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice
Kim, S., Kim, H. S., Chung, K. W., Oh, S. H., Yun, J. W., Im, S., Lee, M., Kim, K., & Lee, M. (2007) · Diabetes · doi:10.2337/db06-1372 · Cited by 80
Cytokines in sera from insulin-dependent diabetic patients at diagnosis
Cavallo, M. G., POZZILLI, J. P., Bird, C., Wadhwa, M., Meager, A., Visalli, N., Gearing, A. J. H., Andreani, D., & Thorpe, R. (1991) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1991.tb05806.x · Cited by 79
Comparing the Relative Role of Perforin/Granzyme Versus Fas/Fas Ligand Cytotoxic Pathways in CD8+ T Cell-Mediated Insulin-Dependent Diabetes Mellitus
Kreuwel, H. T. C., Morgan, D. J. W., Krahl, T., Ko, A., Sarvetnick, N., & Sherman, L. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.8.4335 · Cited by 78
Interleukin-2, Autotolerance, and Autoimmunity
Kroemer, G., Andreu, J. L., Gonzalo, J. A., Gutierrez‐Ramos, J. C., & Martínez-A, C. (1991) · Advances in immunology · doi:10.1016/s0065-2776(08)60825-1 · Cited by 76
Immunological Treatment of Autoimmune Diseases
Kalden, J. R., Breedveld, F. C., Burkhardt, H., & Burmester, G. R. (1998) · Advances in immunology · doi:10.1016/s0065-2776(08)60564-7 · Cited by 74
EVIDENCE THAT MACROPHAGES ARE REQUIRED FOR T-CELL INFILTRATION AND REJECTION OF FETAL PIG PANCREAS XENOGRAFTS IN NONOBESE DIABETIC MICE1
Fox, A., Koulmanda, M., MANDEL, T. E., van Rooijen, N., & Harrison, L. C. (1998) · Transplantation · doi:10.1097/00007890-199812150-00002 · Cited by 73
Self-citation
Toll‐like receptor 4 suppression leads to islet allograft survival
Goldberg, A. R., Parolini, M., Chin, B. Y., Czismadia, E., Otterbein, L. E., Bach, F. H., & Wang, H. (2007) · The FASEB Journal · doi:10.1096/fj.06-7910com · Cited by 72
Suppressor of Cytokine Signaling-1 Regulates the Sensitivity of Pancreatic β Cells to Tumor Necrosis Factor
Chong, M. M. W., Thomas, H. E., & Kay, T. W. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110214200 · Cited by 72
Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation.
Kontakou, M., Sturgess, R. P., Przemioslo, R. T., Limb, G. A., Nelufer, J. M., & Ciclitira, P. J. (1994) · Gut · doi:10.1136/gut.35.8.1037 · Cited by 70
COX-2 Inhibition Prevents Insulin-Dependent Diabetes in Low-Dose Streptozotocin-Treated Mice
Tabatabaie, T., Waldon, A. M., Jacob, J. M., Floyd, R. A., & Kotake, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2959 · Cited by 68
Toll-Like Receptor 4 Deficiency Accelerates the Development of Insulin-Deficient Diabetes in Non-Obese Diabetic Mice
Gülden, E., Ihira, M., Ohashi, A., Reinbeck, A. L., Freudenberg, M. A., Kolb, H., & Burkart, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075385 · Cited by 66
Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug
Gross, D. J., Sidi, H., Weiss, L., Kalland, T., Rosenmann, E., & Slavin, S. (1994) · Diabetologia · doi:10.1007/bf00399792 · Cited by 66
Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus
Suresh, Y., & Das, U. N. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.11.006 · Cited by 64
Indispensable Role for TNF-α and IFN-γ at the Effector Phase of Liver Injury Mediated by Th1 Cells Specific to Hepatitis B Virus Surface Antigen
Ohta, A., Sekimoto, M., Sato, M., Koda, T., Nishimura, S., Iwakura, Y., Sekikawa, K., & Nishimura, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.956 · Cited by 64
A New Strategy Toward Improving Immunoprotection in Cell Therapy for Diabetes Mellitus: Long-Functioning PEGylated Islets In Vivo
Lee, D. Y., Park, S. J., Nam, J. H., & Byun, Y. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.615 · Cited by 63
Viral infection induces cytokine release by beta islet cells.
Cavallo, M. G., Baroni, M. G., Toto, A., Gearing, A. J. H., Forsey, T., Andreani, D., Thorpe, R., & Pozzilli, P. (1992) · PubMed Central · Cited by 63
Expression of a Dominant Negative Inhibitor of NF-κB Protects MIN6 β-Cells from Cytokine-Induced Apoptosis
Baker, M. S., Chen, X., Cao, X. C., & Kaufman, D. B. (2001) · Journal of Surgical Research · doi:10.1006/jsre.2001.6121 · Cited by 62
Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice
Hirasawa, K., Jun, H., Maeda, K., Kawaguchi, Y., ITAGAKI, S., Mikami, T., Baek, H. S., Doi, K., & Yoon, J. (1997) · Journal of Virology · doi:10.1128/jvi.71.5.4024-4031.1997 · Cited by 61
The Novel Anti-inflammatory Compound, Lisofylline, Prevents Diabetes in Multiple Low-Dose Streptozotocin-Treated Mice
Yang, Z., Chen, M., Fialkow, L. B., Ellett, J. D., Wu, R., & Nadler, J. L. (2003) · Pancreas · doi:10.1097/00006676-200305000-00021 · Cited by 60
Expression of Tumour Necrosis Factor-α, Interleukin-6, and Interleukin-2 mRNA in the Jejunum of Patients with Coeliac Disease
Kontakou, M., Przemioslo, R. T., Sturgess, R. P., Limb, G. A., & Ciclitira, P. J. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509093307 · Cited by 60
Cytokines as Mediators of Autoimmune Diabetes and Diabetic Complications
PANKEWYCZ, O. G., Guan, J., & BENEDICT, J. F. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-164 · Cited by 58
Alginate Polylysine Microcapsules as Immune Barrier: Permeability of Cytokines and Immunoglobulins over the Capsule Membrane
Kulseng, B. E., Thu, B. J., Espevik, T., & Skjåk‐Bræk, G. (1997) · Cell Transplantation · doi:10.1177/096368979700600405 · Cited by 59
Recent progress in research on beta-cell apoptosis by cytokines
Kim, K. (2009) · Frontiers in bioscience · doi:10.2741/3271 · Cited by 58
cFLIP Protein Prevents Tumor Necrosis Factor-α–Mediated Induction of Caspase-8–Dependent Apoptosis in Insulin-Secreting βTc-Tet Cells
Cottet, S., Dupraz, P., Hamburger, F., Dolci, W., Jaquet, M., & Thorens, B. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1805 · Cited by 58
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming
Wang, R., Qiu, X., Pan, R., Fu, H., Zhang, Z., Wang, Q., Chen, H., Wu, Q., Pan, X., Zhou, Y., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211779 · Cited by 57
An Overview of the Immune System with Specific Reference to Membrane Encapsulation and Islet Transplantation
Gray, D. W. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03835.x · Cited by 56
Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction
Allison, J., Thomas, H. E., Beck, D., Brady, J. L., Lew, A. M., Elefanty, A. G., Kosaka, H., Kay, T. W. H., Huang, D. C. S., & Strasser, A. (2000) · International Immunology · doi:10.1093/intimm/12.1.9 · Cited by 56
Destruction of rat pancreatic islet beta-cells by cytokines involves the production of cytotoxic aldehydes
Suarez‐Pinzon, W. L., Strynadka, K. D., & Rabinovitch, A. (1996) · Endocrinology · doi:10.1210/en.137.12.5290 · Cited by 56
SOCS-1 Protein Prevents Janus Kinase/STAT-dependent Inhibition of β Cell Insulin Gene Transcription and Secretion in Response to Interferon-γ
Cottet, S., Dupraz, P., Hamburger, F., Dolci, W., Jaquet, M., & Thorens, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103235200 · Cited by 55
Genetic polymorphism of the human tumor necrosis factor region in insulin-dependent diabetes mellitus linkage disequilibrium of TNFab microsatellite alleles with HLA haplotypes
Monos, D. S., Kamoun, M., Udalova, I. A., Csánky, E., Cizman, B., Turetskaya, R. L., Smirnova, J. B., Zharkov, V. G., Gasser, D. L., Zmijewski, C. M., et al. (1995) · Human Immunology · doi:10.1016/0198-8859(95)00060-h · Cited by 55
Evidence of Diminished Glucose Stimulation and Endoplasmic Reticulum Function in Nonoscillatory Pancreatic Islets
Jahanshahi, P., Wu, R., Carter, J. D., & Nunemaker, C. S. (2008) · Endocrinology · doi:10.1210/en.2008-0773 · Cited by 53
Reduction in insulitis following administration of IFN-γ and TNF-α in the NOD mouse
Campbell, I. L., Oxbrow, L., & Harrison, L. C. (1991) · Journal of Autoimmunity · doi:10.1016/0896-8411(91)90022-5 · Cited by 51
Self-citation
Effect of polyethylene glycol grafted onto islet capsules on prevention of splenocyte and cytokine attacks
Lee, D. Y., Nam, J. H., & Byun, Y. (2004) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856204774196144 · Cited by 49
Cytotoxic effect of IFN-γ plus TNF-α on human islet cells
Soldevila, G., Buscema, M., Doshi, M., James, R. F. L., Bottazzo, G. F., & Pujol‐Borrell, R. (1991) · Journal of Autoimmunity · doi:10.1016/0896-8411(91)90025-8 · Cited by 49
Characterization of self-glutamic acid decarboxylase 65-reactive CD4+ T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus
Tabata, H., Kanai, T., Yoshizumi, H., Nishiyama, S., Fujimoto, S., Matsuda, I., Yasukawa, M., Matsushita, S., & Nishimura, Y. (1998) · Human Immunology · doi:10.1016/s0198-8859(98)00050-0 · Cited by 46
Cytokines and autoimmunity
Cavallo, M. G., Pozzilli, P., & Thorpe, R. (1994) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1994.tb06220.x · Cited by 47
Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes Mellitus
Pelegrín, M., Devedjian, J. C., Costa, C., Visa, J., Solanes, G., Pujol, A., Asins, G., Valera, A., & Bosch, F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12332 · Cited by 46
Lipotoxicity versus adipotoxicity—The deleterious effects of adipose tissue on beta cells in the pathogenesis of type 2 diabetes
Eldor, R., & Raz, I. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.06.004 · Cited by 43

Authors: Campbell, I. L., Iscaro, A., & Harrison, L. C.
Affiliations: The Royal Melbourne Hospital (AU)
ORCID: Campbell, I L
Harrison, L C
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1988-10-01
Volume: 141
Issue: 7
Pages: 2325-2329
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.141.7.2325
OpenAlex: W1565885233
Cited by: 233
References: 0
Citations by year: 2022: 4 · 2021: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 2
FWCI: 20.00
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Keywords: interferon-gamma, TNF-α, pancreatic islets, beta-cell cytotoxicity, glucose-stimulated insulin secretion, type 1 diabetes, beta cell destruction, cytokine synergy, islet morphology, insulin content
MeSH terms: Animals, Cells, Cultured, Drug Combinations, Glucose, Insulin, Interferon-gamma, Islets of Langerhans, Kinetics, Tumor Necrosis Factor-alpha, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IFN- gamma and tumor necrosis factor- alpha . Cytotoxicity to murine islets of Langerhans.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks