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Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.
Abstract
Four mAb able to recognize transforming growth factor-beta 2 (TGF-beta)2 were obtained. One of these mAb, 1D11.16, was able to neutralize the biological activity of both TGF-beta 1 and beta 2 in vitro. This was demonstrated in an Il-1, PHA-dependent thymocyte mitogenic assay that is inhibitable by TGF-beta in a dose-dependent manner. All four mAb recognized the dimeric form of TGF-beta 2 in Western blots. The mAb were also found to immunoprecipitate [125I]-TGF-beta 2. mAb 3C7.14 coupled to Sepharose could efficiently immunoaffinity purify TGF-beta 2 from a complex mixture of proteins. Affinity constants were determined for the four mAb and they ranged from 3.4 x 108 to 1.6 x 107 L/mol.
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Cited by
Powrie, F., Carlino, J., Leach, M. W., Mauze, S., & Coffman, R. L. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.6.2669 · Cited by 894
TGFβ is a master regulator of radiation therapy-induced antitumor immunity
Vanpouille-Box, C., Diamond, J. M., Pilones, K. A., Zavadil, J., Babb, J. S., Formenti, S. C., Barcellos-Hoff, M. H., & Demaria, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3511 · Cited by 514
Corneal stromal wound healing in refractive surgery: the role of myofibroblasts
Jester, J. V., Petroll, W. M., & Cavanagh, H. D. (1999) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(98)00021-4 · Cited by 454
The dynamic roles of TGF‐β in cancer
Meulmeester, E., & ten Dijke, P. (2011) · The Journal of Pathology · doi:10.1002/path.2785 · Cited by 388
The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis
Neel, J.-C., Humbert, L., & Lebrun, J.-J. (2012) · ISRN Molecular Biology · doi:10.5402/2012/381428 · Cited by 345
Metadata
- Authors
- Dasch, J. R., Pace, D. R., Waegell, W., Inenaga, D., & Ellingsworth, L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-03-01
- Volume
- 142
- Issue
- 5
- Pages
- 1536-1541
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1503228526
- Cited by
- 293
- References
- 0
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Dasch, J. R., Pace, D. R., Waegell, W., Inenaga, D., & Ellingsworth, L. (1989). Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. The Journal of Immunology. https://doi.org/10.4049/jimmunol.142.5.1536
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
