The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.
Open accessAbstract
A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation of function of protective cells as CD45RB(low) CD4+ cells from IL-4-deficient mice were fully effective. These results identify a subpopulation of peripheral CD4+ cells and TGF-beta as critical components of the natural immune regulatory mechanism, which prevents the development of pathogenic Th1 responses in the gut, and suggests that this immunoregulatory population is distinct from Th2 cells.
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Cites
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Cited by
Interleukin-10 and the Interleukin-10 Receptor
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Self-citationTransforming growth factor-β induces development of the TH17 lineage
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Cytokines in inflammatory bowel disease
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The immunological and genetic basis of inflammatory bowel disease
Bouma, G., & Strober, W. (2003) · Nature Reviews Immunology · doi:10.1038/nri1132 · Cited by 1,767
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
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Metadata
- Authors
- Powrie, F., Carlino, J., Leach, M. W., Mauze, S., & Coffman, R. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-06-01
- Volume
- 183
- Issue
- 6
- Pages
- 2669-2674
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2118202213
- Cited by
- 894
- References
- 28
- FWCI
- 16.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. https://app.cochat.ai/papers/10.1084/jem.183.6.2669
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- Powrie, F., Carlino, J., Leach, M. W., Mauze, S., & Coffman, R. L. (1996). A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.6.2669
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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