The DOI matches its Crossref record.
Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.
Abstract
A cDNA clone encoding the human lymphocyte differentiation Ag CD38 was isolated from a mixture of four different lymphocyte CDNA libraries expressed transiently in COS cells and screened by panning with mAb. Transfected COS cells expressed a surface protein of Mr 46,000 that was similar to the native CD38 molecule expressed on the B cell line Daudi and the T cell leukemia HPB-ALL and which was recognized by each of the CD38 specific mAb HIT-2, T16, T168, HB7, 5D2, ICO-18, and ICO-20. The CD38 cDNA sequence predicts an unusual 30-kDa polypeptide with a short N-terminal cytoplasmic tail, and a carboxyl-terminal extracellular domain carrying the four potential N-linked glycosylation sites. The absence of significant homology with other known surface Ag including members of the Ig superfamily ruled out the possibility that CD38 was the human homologue of the murine Qa2 molecule as has been suggested previously. PvuII digests of human genomic DNA revealed a polymorphism linked to the CD38 gene.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“CD38 is ubiquitously expressed by immune cells, and its expression increases during inflammatory conditions8-10.”
From Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) · cites this paper as [8]
Citations
Cited by
Sorted by citations
Items 301–345 of 345
A Yeast Expression System of High Efficiency for Producing Recombinant Enzymes
Munshi, C. B., & Lee, H. C. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0269-2_5 · Cited by 2
Emerging chemical strategies for CD38 inhibition: restoring NAD+ metabolism and disease control
Zhang, Z., Ansari, A. J., Fayne, E., & Zhang, Y. (2026) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2026.118676 · Cited by 1
Costa‐Carvalho, B. T., Viana, M. A., Brunialti, M. K. C., Kallas, E. G., & Salomão, R. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02446.x · Cited by 1
Han, M., Kwark, O.-S., Jang, K. Y., Lee, D., Oh, B.-C., An, N., & Kim, U. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00267-0 · Cited by 1
Calcium Signaling Mediated by Cyclic ADP-Ribose and NAADP: Roles in Cellular Response to Stress
Lee, H. C. (2002) · Cell and molecular responses to stress · doi:10.1016/s1568-1254(02)80009-2 · Cited by 1
Immune and metabolic changes leading to diabetes
Hawa, M. I. (2012) · Cited by 1
Menteyne, A. (2007) · OpenGrey (Institut de l'Information Scientifique et Technique)
The role of CD38 expression on NAD levels and cell physiology in a leukaemia model
Al-Abady, Z. N. (2013) · PEARL (University of Plymouth) · doi:10.13140/rg.2.2.34066.66249
Unraveling the NAD Cyclizing and Calcium Signaling Functions of Human CD38
Lee, H. C. (2011) · Wiley eBooks · doi:10.1002/9781118092804.ch3
March, S. (2006) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
WITHDRAWN: CIB1 acts as a partner protein of CD38 in cADPR synthesis
Wang, X., Lu, C., He, X., Hu, S., Sun, A., Hu, M., & Chen, W. R. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.065
Funaro, A., Dianzani, U., Alessio, M., & Malavasi, F. (1992) · Pharmacological Research · doi:10.1016/1043-6618(92)90633-m
Sainova, V. (2013) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp12.004
“…Lin-Sca-1+c-kit+CD34+Flt3+ cells have been established to display up-regulated IL-7 receptor gene expression (Amirayan et al., 1995; Bregenholt et al., 1996; Dallas et al., 2007; Gray-Parkin et al., 2002; Green et al., 1992; Ikuta et al., 1990; Jackson and Bell, 1990; Kondo et al., 1997).”
InfluentialUntersuchungen zu ADP-Ribosylcyclasen in humanen immunkompetenten Zellen
Schweitzer, K. (2002)
Identification and characterization of novel ADP-ribosyl cyclase family members
Hirte, R. M. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)
Medical and Immunological Interventions in HIV - 1 Infection
Hejdeman, B. (2004)
Deaglio, S., Morabito, F., Carbone, A., Gaïdano, G., Aydin, S., Rossi, D., Bergui, L., D'Arena, G. F., Ferrero, E., & Bonello, L. (2013)
La ausencia de CD38 induce un fenotipo autoinmune en el ratón C57BL/6 CD38-/- de edad avanzada
Domínguez-Pantoja, M. (2014)
Chronic Lymphocytic Leukemia and the B-Cell Receptor
Muzio, M., & Caligaris‐Cappio, F. (2008) · CRC Press eBooks · doi:10.3109/9781420068962-5
NAD+ as a Pharmacological Tool to Boost Sirtuin Activity
Houtkooper, R. H. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_2
Will Influenza Vaccination Protect Obese Adults?
Neidich, S. D. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/cx6d-z419
Kelley, T., Sally, U., Joe, P., Ron, T., & Ron, L. (2020) · Archives of Hematology Case Reports and Reviews · doi:10.17352/ahcrr.000023
Análise da tetramerização da proteína CD38 por meio de docking molecular
dos Santos, J. C. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.95.2019.tde-25062020-130911
Investigation of CSF1-CSF1R Signaling in AML-Bone Marrow Stromal Cell Interactions
Rashid, A. (2019) · TSpace (University of Toronto)
子宮内膜癌細胞株における抗癌剤感受性の検討(子宮体部悪性腫瘍VI, 第57回日本産科婦人科学会学術講演会)
茂木, 真., 新美, 茂., 高倉, 聡., 柳田, 聡., 岡本, 愛., 落合, 和., & 田中, 忠. (2005) · 日本産科婦人科學會雜誌
(2021) · Wiley eBooks · doi:10.1002/9781119611288.refs
Bibliography of the current world literature
(1990) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(90)90031-f
(2011) · Wiley eBooks · doi:10.1002/9781444398069.ch1
Zhou, Y., Liang, L., Yue, C., Li, W., Gao, M., Zeng, F., He, J., He, Z., Jin, X., Liao, Q., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1376204/v1
New nucleotide sequence data on the EMBL File Server
(1990) · Nucleic Acids Research · doi:10.1093/nar/18.18.5587
Santos‐Argumedo, L. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0461-4_278
Barclay, A. N., Brown, M. H., Law, S. K. A., McKnight, A. J., Tomlinson, M. G., & van der Merwe, P. A. (1997) · Elsevier eBooks · doi:10.1016/b978-012078185-0/50472-8
ENZYMATIC AND ENDOGENOUS SYNTHESIS OF NAD(P)‐DERIVED CALCIUM‐MOBILIZING MESSENGERS
Lee, H. C., & Zhao, Y. J. (2022) · doi:10.1002/9781119692799.ch3
Kläsener, K., Herrmann, N., Håversen, L., Sundell, T., Sundqvist, M., Lundqvist, C., Manna, P. T., Jonsson, C. A., Visentini, M., Sass, D. L., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3872713/v1
Sculley, E. R., Ricemeyer, E. S., Carroll, R. A., Driver, J. P., Smith, J., Kaufman, J., Hearn, C. J., Balic, A., Chen, P. R., Lamont, S. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.05.606414
Rosecká, M., Koláčková, M., Afshari, M., Jozífková, E., Slezák, R., Krejsek, J., & Radochová, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311544
“Structurally, CD38 is a transmembrane protein, while CD157 is anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage [15–17].”
Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin
Ramakrishnan, L. (2010) · UCL Discovery (University College London)
Whole-exome sequencing identifies a CD38 variant in a Chinese family with hodgkin’s lymphoma
Chen, X., Xie, L., Wu, W., Jiang, M., Cui, Y. M., & Zou, L. (2026) · Annals of Hematology · doi:10.1007/s00277-026-06807-6
“The CD38 gene is located on the short arm of chromosome 4 (4p15) and has a length of over 80 kb, with more than 98% represented by intronic sequences [ 21 , 22].”
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
Miyamoto, T., Matsushima, A., Otubo, A., Song, C., Murata, K., Oti, T., & Sakamoto, H. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70187
“1 Based on sequence analyses, the possible existence of type III CD38, with its catalytic domain facing the cytosol, was first proposed.”
Kibar, F., Çeti̇ner, S., İnal, A. S., Duran, A. Ç., Şeydaoğlu, G., Kuşçu, F., Kömür, S., & Yaman, A. (2026) · Journal of International Medical Research · doi:10.1177/03000605261476785
Enzymatic Regulation of Opioid Antinociception and Tolerance
Hull, L. C. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/0wyq-jx38
Metadata
- Authors
- Jackson, D. G., & Bell, J. I.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-04-01
- Volume
- 144
- Issue
- 7
- Pages
- 2811-2815
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1566643819
- Cited by
- 343
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 10 · 2021: 3 · 2020: 13 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 10
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- CD38, lymphocyte differentiation antigens, cDNA cloning, cell surface glycoproteins, lymphocyte differentiation, B cells, T cells, monoclonal antibodies, N-glycosylation, cytoplasmic tail, genetic polymorphism, Daudi cells
- MeSH terms
- Amino Acid Sequence, Antigens, Differentiation, Base Sequence, Cloning, Molecular, DNA, Genes, Humans, Lymphocytes, Membrane Glycoproteins, Molecular Sequence Data, Molecular Weight, Solubility, Transfection, Blotting, Southern, Antigens, CD, Gene Expression, ADP-ribosyl Cyclase, ADP-ribosyl Cyclase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
