The DOI matches its Crossref record.
Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.
Abstract
The proliferative response of PBMC to hepatitis B virus (HBV) envelope, core, and e Ag was analyzed prospectively in 21 patients with acute self-limited HBV infection and compared with the response of patients with chronic HBV infection and different levels of HBV replication (i.e., hepatitis e Ag (HBeAg)- or anti-HBe-positive) and liver damage (i.e., chronic active hepatitis or chronic asymptomatic carriers). Our results indicate that: 1) HBV-infected subjects who develop a self-limited acute hepatitis show a vigorous PBMC response to hepatitis B core Ag and HBeAg, as expression of T cell activation; 2) appearance of a detectable lymphocyte response to HBV nucleocapsid Ag is temporally associated with the clearance of HBV envelope Ag; 3) in patients with chronic HBV infection the level of T cell responsiveness to hepatitis B core Ag and to HBeAg is significantly lower than that observed during acute infection; 4) T cell sensitization to HBV envelope Ag in acute and chronic HBV infection is usually undetectable and when measurable is expressed transiently and at low levels. These results may reflect immune events of pathogenetic relevance with respect to evolution of disease and viral clearance.
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Citations
Cited by
Immunology of hepatitis B virus and hepatitis C virus infection
Rehermann, B., & Nascimbeni, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1573 · Cited by 1,627
Viral dynamics in hepatitis B virus infection.
Nowak, M. A., Bonhoeffer, S., Hill, A. M., Boehme, R., Thomas, H. C., & McDade, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4398 · Cited by 1,045
Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection
Boni, C., Fisicaro, P., Valdatta, C., Amadei, B., Di Vincenzo, P., Giuberti, T., Laccabue, D., Zerbini, A., Cavalli, A., Missale, G., et al. (2007) · Journal of Virology · doi:10.1128/jvi.02844-06 · Cited by 920
Self-citationStoop, J. N., van der Molen, R. G., Baan, C. C., van der Laan, L. J. W., Kuipers, E. J., Kusters, J. G., & Janssen, H. L. A. (2005) · Hepatology · doi:10.1002/hep.20649 · Cited by 506
Association between an MHC Class II Allele and Clearance of Hepatitis B Virus in the Gambia
Thursz, M. R., Kwiatkowski, D., Allsopp, C. E. M., Greenwood, B. M., Thomas, H. C., & Hill, A. V. S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504203321604 · Cited by 431
Metadata
- Authors
- Ferrari, C., Penna, A., Bertoletti, A., Valli, A., Antoni, A. D., Giuberti, T., Cavalli, A., Petit, M. A., & Fiaccadori, F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-11
- Volume
- 145
- Issue
- 10
- Pages
- 3442-3449
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1845254015
- Cited by
- 505
- References
- 0
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. https://app.cochat.ai/papers/10.4049/jimmunol.145.10.3442
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- Ferrari, C., Penna, A., Bertoletti, A., Valli, A., Antoni, A. D., Giuberti, T., Cavalli, A., Petit, M. A., & Fiaccadori, F. (1990). Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.145.10.3442
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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