Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins

Hawes, G E; Struyk, L; van den Elsen, P J

doi:10.4049/jimmunol.150.5.2033

Cited by 123T-cell and B-cell Immunologyvaccines and immunoinformatics approachesImmunotherapy and Immune Responses

Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins

Hawes, G E, Struyk, L, van den Elsen, P J·1993·The Journal of Immunology

DOI 10.4049/jimmunol.150.5.2033

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Abstract

The TCR confers immunity by the specific recognition of foreign Ag peptides in the context of self-MHC molecules. The mechanisms controlling TCR selection and repertoire generation are not clearly understood and seem to occur in an apparently random, (self) Ag-driven manner. To address the question to what extent the TCR repertoire is randomly shaped or genetically predetermined, we have analyzed the alpha beta TCR repertoire of the CD4+ and CD8+ subsets of peripheral blood lymphocyte cultures of monozygotic twins by using the polymerase chain reaction technique with TCR V region gene family-specific oligonucleotide primers. Our studies demonstrate that there is high concordance in the overall patterns of V gene usage within a pair of twins, particularly in V beta usage (mean V beta CD4+ R2 = 0.869 and CD8+ R2 = 0.833) and to a lesser extent V alpha usage (mean V alpha CD4+ R2 = 0.621 and CD8+ R2 = 0.627); whereas the patterns between unrelated individuals show more variability. This study has also demonstrated that the V alpha and V beta genes are not randomly used within the CD4+ and CD8+ subsets. We observed significant preferential skewing of several V alpha or V beta gene families to either the CD4+ or CD8+ subset in the majority of individuals analyzed (p-value range = 0.0476 to < 0.001). In particular, V alpha 11, 17, 22, and V beta 3, 9, 12, 18 were skewed to the CD4+ subset; whereas V alpha 2, 6, 12, 15, 20 and V beta 7, 14, 17 were skewed to the CD8+ subset. Furthermore, a number of the V genes showed patterns of skewing consistent only within a pair of twins. In three pairs of twins, V beta 2 was skewed to the CD4+ subset, whereas the fourth pair used almost equal frequencies of V beta 2 in both subsets. This observation was made for the V beta 2, 4, 5, 6, 8, 19 and V alpha 7, 16, 18, 21 families. Finally, the ratio of the relative V gene usage frequency that could be observed within an individual was conserved within the sets of twins; for instance, the relative amount of V beta 2 to that of V beta 3 was higher in both individuals of one set of twins, whereas it was lower in all of the other three sets. Together these observations suggest that the predominant influence shaping the TCR repertoire is genetically predetermined, of which, HLA-predicted selection mechanisms exerted during thymic maturation might be contributing factors.

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The precise composition of T- and B-cell repertoires will differ in each individual, even in monozygotic twins.
“Given the great complexity of the T- and B-cell repertoires and a large stochastic element in choosing which cells will respond to a given stimulus, and somatic mutations in B cells, the precise composition will differ in each individual, even in monozygotic twins [66].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [66]

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“[10,11].”
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Posnett, D. N. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44483.x · Cited by 9 · see citing works
Skewed TCRVβ Repertoire in Human Thymus Persists after Thymic Emigration: Influence of Genomic Imposition, Thymic Maturation and Environmental Challenge on Human TCRVβ Usage in vivo
Reinhardt, C., & Melms, A. (1998) · Immunobiology · doi:10.1016/s0171-2985(98)80065-x · Cited by 9 · see citing works
T cell receptor (TCR) V gene segment use in HLA-typed Japanese healthy subjects
Shigematsu, M., Nagai, S., Mikuniya, T., et al. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.d01-14.x · Cited by 9 · see citing works
Differential usage of T-cell receptor V beta gene families by CD4+ and CD8+ T cells in patients with CD8hi common variable immunodeficiency: evidence of a post-thymic effect.
Duchmann, R., Jaffe, J., Ehrhardt, R., et al. (1996) · PubMed · Cited by 8 · see citing works
RESTRICTED TCR V?? REPERTOIRE IN THE HUMAN MIXED LYMPHOCYTE REACTION IS DETERMINED BY THE TCR ON THE RESPONDER CELL AND NOT BY THE STIMULATING ANTIGEN ON THE STIMULATOR CELL1
Barth, C., Palvakis, M., Lavery, P., et al. (1996) · Transplantation · doi:10.1097/00007890-199601150-00025 · Cited by 8 · see citing works
Long-Term T Cell Immune Reconstitution in 2 SCID Patients After BMT
Godthelp, B. C., van Tol, M. J. D., Vossen, J. M. J. J., & van den Elsen, P. J. (1998) · Human Immunology · doi:10.1016/s0198-8859(98)00013-5 · Cited by 7 · see citing works
Self-citation
T-cell receptor repertoire in healthy Sardinian subjects
Bonfigli, S., Doro, M. G., Fozza, C., et al. (2003) · Human Immunology · doi:10.1016/s0198-8859(03)00086-7 · Cited by 7 · see citing works
T‐cell receptor Vβ gene expression in experimental lupus nephritis
SUTMULLER, Baelde, H. J., OUELLETTE, et al. (1998) · Immunology · doi:10.1046/j.1365-2567.1998.00565.x · Cited by 7 · see citing works
T‐Cell Receptor Vβ Gene Utilization in Rheumatoid Arthritis
Jenkins, R. N., & McGINNIS, D. E. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44501.x · Cited by 7 · see citing works
The influence of a maternal chronic hepatitis B virus infection on the repertoire of transcribed T-cell receptor beta chain variable region genes in human cord blood*1
Abbott, W. G. H. (1995) · Hepatology · doi:10.1016/0270-9139(95)90606-1 · Cited by 7 · see citing works
Identification of Two Distinct Function γδ TCR Complexes on the Surface of a Human T Cell Clone
Orsini, D. L. M., Kooy, Y. M. C., Struyk, L., et al. (1995) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1995.tb03598.x · Cited by 6 · see citing works
Self-citation
Evidence for Selective in Vivo Expansion of Synovial Tissue‐Infiltrating CD4+CD45RO+ T‐Lymphocytes on the Basis of CDR3 Diversity
Struyk, L., Hawes, G. E., Dolhain, R. J. E. M., et al. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44512.x · Cited by 6 · see citing works
Self-citation
T-cell receptor usage of interleukin-2-responsive peripheral gamma delta T cells.
Orsini, D. L. M., Kooy, Y. M. C., der Tol, M. A. V., et al. (1995) · PubMed · Cited by 6 · see citing works
Self-citation
Contact Allergy in Children
Goossens, A. E., Neyens, K., & Vigan, M. (2001) · Springer eBooks · doi:10.1007/978-3-662-10302-9_30 · Cited by 6 · see citing works
T-Cell Immune Reconstitution in Pediatric Leukemia Patients After Allogeneic Bone Marrow Transplantation With T-Cell–Depleted or Unmanipulated Grafts: Evaluation of Overall and Antigen-Specific T-Cell Repertoires
Godthelp, B. C., van Tol, M. J. D., Vossen, J. M. J. J., et al. (1999) · Blood · doi:10.1182/blood.v94.12.4358.424k02_4358_4369 · Cited by 6 · see citing works
Self-citation
Heterogeneity of Rearranged T Cell Receptor Vα and Vβ Gene Transcripts in Synovial Fluid T Cells of HLA-B27 Positive Reactive Arthritis Patients
Verjans, G. M. G. M., Klaren, V. N. A., Leirisalo‐Repo, M., et al. (1996) · Clinical Rheumatology · doi:10.1007/bf03342655 · Cited by 6 · see citing works
“To ensure that the amount of PCR products synthesized was proportional to the amount ofTCR mRNA present in the original sample, the amount of TCR specific CDNA and the number of PCR cycles to be used were determined for each CDNA preparation, using the 5' sense Ca (Ca5 ') and 3' antisense Ca (Ca3') primer (12,13,16).”
BackgroundMethod
Characterization of T‐Cell Receptor Vβ Repertoire in Ovarian Tumour‐Reacting CD3+ CD8+ CD4− CTL Lines
Fisk, B. A., FLYTZANES, C. N., Pollack, M. S., et al. (1994) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1994.tb03510.x · Cited by 6 · see citing works
SELECTIVE T CELL RECEPTOR V?? GENE USAGE BY ALLOREACTIVE T CELLS RESPONDING TO DEFINED HLA-DR ALLELES
Lobashevsky, A. L., Kotb, M., & Gaber, A. O. (1996) · Transplantation · doi:10.1097/00007890-199611150-00027 · Cited by 5 · see citing works
Modulation of the T cell receptor beta chain repertoire after heart transplantation
Doumaid, K., van Miert, P. P. M. C., Vaessen, L. M. B., et al. (2000) · Transplant Immunology · doi:10.1016/s0966-3274(00)00008-3 · Cited by 5 · see citing works
Contact allergy in monozygous twins
Thestrup‐Oederseb, K. (1997) · Contact Dermatitis · doi:10.1111/j.1600-0536.1997.tb00924.x · Cited by 5 · see citing works
T cell receptor genetics, autoimmunity and asthma.
Frew, A. J., & Dasmahapatra, J. (1995) · Thorax · doi:10.1136/thx.50.9.919 · Cited by 5 · see citing works
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.
Vincenti, M., Coon, C. I., & Brinckerhoff, C. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199811)41:11 · Cited by 239 · see citing works
No luck replicating the immune response in twins
Baxter, A. G., & Hodgkin, P. D. (2015) · Genome Medicine · doi:10.1186/s13073-015-0156-0 · Cited by 4 · see citing works
“T- and B-cell antigen receptors arise from probabilistic gene assortment and differ between identical individuals, affecting their immune responses [9].”
Background
Preservation of Functioning Human Thyroid “Organoids” in the scid Mouse. IV. In Vivo Selection of an Intrathyroidal T Cell Receptor Repertoire*
Martin, A., Matsuoka, N., Zhang, J., et al. (1997) · Endocrinology · doi:10.1210/endo.138.11.5537 · Cited by 4 · see citing works
T Cells as primary players in rheumatoid arthritis
Falta, M. T., & Kotzin, B. L. (1998) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8823-3_11 · Cited by 4 · see citing works
Correction of Abnormal T-Cell Receptor Repertoire During Interferon-α Therapy in Patients With Hairy Cell Leukemia
Kluin‐Nelemans, H. C., Kester, M. G. D., van deCorput, L., et al. (1998) · Blood · doi:10.1182/blood.v91.11.4224.411k19_4224_4231 · Cited by 4 · see citing works
Influence of antigenic experience on BJ gene segment usage in human CD4+ T cells
Walser-Kuntz, D. R. (1997) · International Immunology · doi:10.1093/intimm/9.12.1785 · Cited by 3 · see citing works
Mycobacterium bovisBCG Scar Status and HLA Class II Alleles Influence Purified Protein Derivative-Specific T-Cell Receptor Vβ Expression in Pulmonary Tuberculosis Patients from Southern India
Shanmugalakshmi, S., Dheenadhayalan, V., Muthuveeralakshmi, P., et al. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4544-4553.2003 · Cited by 3 · see citing works

Restriction in T‐Cell Receptor Repertoire in a Patient Affected by Trichothiodystrophy and CD4+ Lymphopenia
Cancrini, C., Romiti, M. L., Cesare, S. D., et al. (2002) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2002.01122.x · Cited by 6 · see citing works
TCRosetta: a powerful server for analyzing and annotating T-cell receptor repertoirePreprint
Yue, T., Chen, S., Shen, W., Cheng, L., & Guo, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1621224/v1 · Cited by 1 · see citing works
Methods for comparing the diversity of samples of the T cell receptor repertoire
Venturi, V., Kedzierska, K., Turner, S. J., Doherty, P. C., & Davenport, M. P. (2007) · Journal of Immunological Methods · doi:10.1016/j.jim.2007.01.019 · Cited by 185 · see citing works
The Influence of Non‐HLA Genes on the Human T‐Cell Receptor Repertoire
Akolkar, P. N., Gulwani-Akolkar, B., Robinson, M. A., & Silver, J. E. (1995) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1995.tb03651.x · Cited by 10 · see citing works
[T cell receptor (TCR) repertoire and common analytical tools for high-throughput sequencing].
Zhang, M., Li, J., Shi, B., et al. (2021) · PubMed · Cited by 2 · see citing works

Authors: Hawes, G. E., Struyk, L., & van den Elsen, P. J.
Affiliations: Leiden University Medical Center (NL)
Department of Immunohematology, University Hospital Leiden ,
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1993-03-01
Volume: 150
Issue: 5
Pages: 2033-2045
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.150.5.2033
OpenAlex: W1594245074
Cited by: 119
References: 0
Citations by year: 2021: 1 · 2019: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 1
FWCI: 9.06
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: T cell receptor V gene usage, T cell receptor repertoire, CD4+ T cells, CD8+ T cells, monozygotic twins, V beta gene usage
MeSH terms: Adult, Base Sequence, Female, Fluorescent Antibody Technique, Gene Frequency, Humans, Molecular Sequence Data, Twins, Monozygotic, CD4 Antigens, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, alpha-beta, CD8 Antigens

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Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins

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