The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Genetic and Epigenetic Regulation of PD-1 Expression
Open accessAbstract
The inhibitory immune receptor programmed cell death-1 (PD-1) is intricately regulated. In T cells, PD-1 is expressed in response to most immune challenges, but it is rapidly downregulated in acute settings, allowing for normal immune responses. On chronically stimulated Ag-specific T cells, PD-1 expression remains high, leading to an impaired response to stimuli. Ab blockade of PD-1 interactions during chronic Ag settings partially restores immune function and is now used clinically to treat a variety of devastating cancers. Understanding the regulation of PD-1 expression may be useful for developing novel immune-based therapies. In this review, the molecular mechanisms that drive dynamic PD-1 expression during acute and chronic antigenic stimuli are discussed. An array of cis-DNA elements, transcription factors, and epigenetic components, including DNA methylation and histone modifications, control PD-1 expression. The interplay between these regulators fine-tunes PD-1 expression in different inflammatory environments and across numerous cell types to modulate immune responses.
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Citations
Cites
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Cited by
Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
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T Cell Dysfunction and Exhaustion in Cancer
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“When TCR stimulation and IL-6 or IL-12 treatment were combined, both H3K4me1 and H3K27 acetylation were contributed to increased PD-1 expression (Bally et al., 2016).”
BackgroundA snapshot of the PD-1/PD-L1 pathway
Ghosh, C., Luong, G., & Sun, Y. (2021) · Journal of Cancer · doi:10.7150/jca.57334 · Cited by 292
Resistance to Checkpoint Inhibition in Cancer Immunotherapy
Barrueto, L., Caminero, F., Cash, L., Makris, C., Lamichhane, P., & Deshmukh, R. R. (2020) · Translational Oncology · doi:10.1016/j.tranon.2019.12.010 · Cited by 281
Metadata
- Authors
- Bally, A. P. R., Austin, J. W., & Boss, J. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03
- Volume
- 196
- Issue
- 6
- Pages
- 2431-2437
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2336076245
- Cited by
- 243
- References
- 16
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Bally, A. P. R., Austin, J. W., & Boss, J. M. (2016). Genetic and Epigenetic Regulation of PD-1 Expression. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1502643
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
