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Cited by 249Immune cells in cancerCytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Modulation of murine macrophage function by IL-13

Doherty, T M, Kastelein, R, Menon, S, Andrade, S, Coffman, R L·1993·The Journal of Immunology
DOI 10.4049/jimmunol.151.12.7151
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Abstract

Activated macrophages are important effector cells for immune response to many parasites and immune responses are strongly modulated in part by the effect of Th cell-derived cytokines on macrophages. Th1-derived cytokines such as IFN-gamma are strong stimulators of macrophage activation, while cytokines produced by Th2 cells, including IL-4 and IL-10, have been shown under some conditions to inhibit macrophage activities associated with inflammatory responses. IL-13, a recently described cytokine produced by Th2 cells, is also capable of down-modulating macrophage activity in a manner similar to that previously described for IL-4. Treatment of activated macrophages with IL-13 reduces the production of inflammatory monokines in response to IFN-gamma or LPS, both potent stimulators of these factors. In addition, IL-13 decreases the production of nitric oxide by activated macrophages. Nitric oxide has been implicated in both macrophage cytotoxicity and macrophage-associated immunosuppression. The suppression of nitric oxide by IL-13 leads to a decrease in parasiticidal activity by activated macrophages. However, our data indicate that IL-13 has pleiotropic effects, while the inflammatory potential of activated macrophages is significantly reduced, the potential of other macrophage subsets is unimpaired. These data indicate that IL-13 could be a potent modulator of immune responses in vivo, with effects that may embrace both macrophage suppressive and macrophage potentiating functions.

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  • Alternatively activated macrophages do not require priming because IL-4 and/or IL-13 can act as sufficient stimuli.

    “Alternatively activated macrophages do not require any priming, because interleukins IL-4 and/or IL-13 can act as enough stimuli [190,191].”

    From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [191]

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Authors
Doherty, T. M., Kastelein, R., Menon, S., Andrade, S., & Coffman, R. L.
Affiliations
Department of Immunology, DNAX Research Institute for Cellular and Molecular Biology , Palo Alto, CA 94304
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
1993-12
Volume
151
Issue
12
Pages
7151-7160
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.151.12.7151
OpenAlex
W1537669972
Cited by
249
References
0
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 3
FWCI
5.53
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
IL-13, macrophage activation, Th2 cytokines, nitric oxide, macrophage cytotoxicity, antiparasitic activity, interferon-gamma, LPS, immunosuppression, Th1/Th2 balance, macrophage subsets
MeSH terms
Animals, Antigens, Surface, Cytotoxicity, Immunologic, Female, Interleukins, Macrophage Activation, Macrophages, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Phagocytosis, Cytokines, Antigen Presentation, Interleukin-13, Mice, In Vitro Techniques

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