Cited by 56Chemokine receptors and signalingInflammation biomarkers and pathwaysCell Adhesion Molecules Research

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Biologic activities of the murine beta -chemokine TCA3.

Luo, Y, Laning, J, Devi, S, Mak, J, Schall, T J, Dorf, M E·1994·The Journal of Immunology

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Abstract

The murine beta-chemokine TCA3 was purified to homogeneity. The biologic activities of the purified glycoprotein were evaluated in vivo and in vitro. Mice injected i.p. with 1- to 100-ng purified rTCA3 exhibited a rapid influx of neutrophils and macrophages. Increased numbers of neutrophils and monocytes were observed in peripheral blood within 15 min and peak at 45 min. After 45 min neutrophil and macrophage levels were increased in the peritoneal exudate with peak levels occurring at 2 h, followed by a subsequent decline by 24 h. Inflammatory responses were induced in a dose-dependent fashion. The in vivo inflammatory responses were mirrored by the pattern of TCA3-induced chemotaxis in vitro. Neutrophils and macrophages responded to similar concentrations of TCA3 (3 x 10(-9) to 10(-8) M). Lymph node cells responded to other chemokines but did not migrate to TCA3. We also demonstrated that rTCA3 stimulates a transient increase in cytoplasmic free calcium in monocytic cells through a PTX-sensitive pathway. Cross-desensitization studies indicate that TCA3 acts independently of other beta-chemokines (MIP-1 alpha and RANTES) and the alpha-chemokine IL-8. Furthermore, TCA3 does not induce a Ca2+ flux in cells transfected with cDNA for the C-C CKR-1 chemokine receptor, supporting the conclusion that there are distinct receptors for TCA3.

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Authors: Luo, Y., Laning, J., Devi, S., Mak, J., Schall, T. J., & Dorf, M. E.
Affiliations: Harvard University (US)
ORCID: Luo, Y
Devi, S
Dorf, M E
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1994-11
Volume: 153
Issue: 10
Pages: 4616-4624
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.153.10.4616
OpenAlex: W1591503413
Cited by: 56
References: 0
Citations by year: 2022: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 3 · 2012: 1
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca056057-04)
National Cancer Institute (CA56057, T32CA009141)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: CC chemokines, neutrophil chemotaxis, macrophage chemotaxis, inflammation, peritoneal exudate, calcium signaling, cross-desensitization, chemokine receptors, MIP-1α, RANTES, interleukin-8, lymph node cells
MeSH terms: Amino Acid Sequence, Animals, Calcium, Chemotactic Factors, Female, Flow Cytometry, Cricetinae, Inflammation, Leukocytes, Macrophages, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Molecular Sequence Data, Signal Transduction, Cytokines, CHO Cells, Chemokines, CC, Mice, Receptors, CCR8, Chemokine CCL1

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Biologic activities of the murine beta -chemokine TCA3.

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