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Biologic activities of the murine beta -chemokine TCA3.
Abstract
The murine beta-chemokine TCA3 was purified to homogeneity. The biologic activities of the purified glycoprotein were evaluated in vivo and in vitro. Mice injected i.p. with 1- to 100-ng purified rTCA3 exhibited a rapid influx of neutrophils and macrophages. Increased numbers of neutrophils and monocytes were observed in peripheral blood within 15 min and peak at 45 min. After 45 min neutrophil and macrophage levels were increased in the peritoneal exudate with peak levels occurring at 2 h, followed by a subsequent decline by 24 h. Inflammatory responses were induced in a dose-dependent fashion. The in vivo inflammatory responses were mirrored by the pattern of TCA3-induced chemotaxis in vitro. Neutrophils and macrophages responded to similar concentrations of TCA3 (3 x 10(-9) to 10(-8) M). Lymph node cells responded to other chemokines but did not migrate to TCA3. We also demonstrated that rTCA3 stimulates a transient increase in cytoplasmic free calcium in monocytic cells through a PTX-sensitive pathway. Cross-desensitization studies indicate that TCA3 acts independently of other beta-chemokines (MIP-1 alpha and RANTES) and the alpha-chemokine IL-8. Furthermore, TCA3 does not induce a Ca2+ flux in cells transfected with cDNA for the C-C CKR-1 chemokine receptor, supporting the conclusion that there are distinct receptors for TCA3.
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“Two additional genes in this locus include CCL1, encoding a well-characterized proinflammatory chemokine,39 and CCL11, which encodes eotaxin-1”
From Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease (2015) · cites this paper as [39]
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Lloyd, C. M., Minto, A. W., Dorf, M. E., Proudfoot, A., Wells, T. N. C., Salant, D. J., & Gutierrez-Ramos, J.-C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.7.1371 · Cited by 496
Self-citationGonzalo, J. A., Lloyd, C. M., Kremer, L., Finger, E., Martinez-A, C., Siegelman, M. H., Cybulsky, M., & Gutierrez-Ramos, J. C. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119045 · Cited by 427
Rothenberg, M. E., Luster, A. D., & Leder, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8960 · Cited by 345
IFN-γ Shapes Immune Invasion of the Central Nervous System Via Regulation of Chemokines
Tran, E. H., Prince, E. N., & Owens, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2759 · Cited by 299
Furie, M. B., & Randolph, G. J. (1995) · Europe PMC (PubMed Central) · Cited by 297
Metadata
- Authors
- Luo, Y., Laning, J., Devi, S., Mak, J., Schall, T. J., & Dorf, M. E.
- Affiliations
- Harvard University (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-11
- Volume
- 153
- Issue
- 10
- Pages
- 4616-4624
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1591503413
- Cited by
- 56
- References
- 0
- Citations by year
- 2022: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 3 · 2012: 1
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca056057-04)
- National Cancer Institute (CA56057, T32CA009141)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- CC chemokines, neutrophil chemotaxis, macrophage chemotaxis, inflammation, peritoneal exudate, calcium signaling, cross-desensitization, chemokine receptors, MIP-1α, RANTES, interleukin-8, lymph node cells
- MeSH terms
- Amino Acid Sequence, Animals, Calcium, Chemotactic Factors, Female, Flow Cytometry, Cricetinae, Inflammation, Leukocytes, Macrophages, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Molecular Sequence Data, Signal Transduction, Cytokines, CHO Cells, Chemokines, CC, Mice, Receptors, CCR8, Chemokine CCL1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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