B cell antigen receptor cross-linking induces phosphorylation of the p21 ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.
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- BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutationInui, Seiji, Maeda, Kazuhiko, Hua, Ding Rong, Yamashita, Takeshi, Yamamoto, Hideyuki, Miyamoto, Eishichi, Aizawa, Shinichi, Sakaguchi, Nobuo · 2002 · International Immunology