B cell antigen receptor cross-linking induces phosphorylation of the p21 ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

Saxton, T M; van Oostveen, I; Bowtell, D; Aebersold, R; Gold, M R

doi:10.4049/jimmunol.153.2.623

Cited by 164Protein Kinase Regulation and GTPase SignalingProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

B cell antigen receptor cross-linking induces phosphorylation of the p21 ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

Saxton, T M, van Oostveen, I, Bowtell, D, Aebersold, R, Gold, M R·1994·The Journal of Immunology

DOI 10.4049/jimmunol.153.2.623

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Abstract

Ligation of the B cell AgR activates p21ras (Ras). We have investigated the effects of AgR ligation on three proteins that have been implicated as regulators of Ras: SHC, GRB-2, and mSOS1. We show that AgR cross-linking in B cells stimulated tyrosine and serine phosphorylation of SHC. This correlated with the formation of complexes containing SHC, GRB-2, mSOS1, and an unidentified 145-kDa tyrosine-phosphorylated protein. These complexes were present in the cytosol, as well as in the membrane fraction of the cells, where Ras is located. By using a GRB-2 fusion protein to probe blots, we showed that SHC was the major protein that GRB-2 bound to in anti-Ig-stimulated B cells. This argues that SHC couples GRB-2/mSOS1 to the 145-kDa protein and that SHC is likely to be essential for mSOS1 function in B cells. Finally, we found that AgR cross-linking stimulated phosphorylation of mSOS1 and that this could be blocked by an inhibitor of protein kinase C. Thus, signaling by the B cell AgR stimulates phosphorylation of SHC and mSOS1 and induces the formation of membrane-associated complexes containing SHC, GRB-2, mSOS1, and a 145-kDa protein. These events may be important for activation of Ras by the AgR.

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SHIP1 was originally observed in hematopoietic cells after cytokines and growth factors induced tyrosine phosphorylation of this 145-kDa protein.
“SHIP1 was originally observed in hematopoietic cells after a variety of cytokines and growth factors induced the tyrosine phosphorylation of this 145-kDa protein [98–104].”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [100]

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Authors: Saxton, T. M., van Oostveen, I., Bowtell, D., Aebersold, R., & Gold, M. R.
Affiliations: University of British Columbia (CA)
the Biomedical Research Centre, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,
ORCID: Bowtell, D
Aebersold, R
Gold, M R
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1994-07
Volume: 153
Issue: 2
Pages: 623-636
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.153.2.623
OpenAlex: W1488229599
Cited by: 164
References: 0
Citations by year: 2023: 3 · 2022: 1 · 2020: 3 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 1
FWCI: 7.21
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: B cell receptor, receptor cross-linking, Shc, Grb2, Ras activation, tyrosine phosphorylation, protein kinase C, B cell signaling
MeSH terms: Animals, Membrane Proteins, Mice, Inbred DBA, Phosphoproteins, Phosphorylation, Proteins, Receptors, Antigen, B-Cell, Serine, Tumor Cells, Cultured, Tyrosine, Proto-Oncogene Proteins p21(ras), Son of Sevenless Proteins, Adaptor Proteins, Signal Transducing, Mice, GRB2 Adaptor Protein

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B cell antigen receptor cross-linking induces phosphorylation of the p21 ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

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