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Molecular cloning and functional characterization of human lymphotactin
Abstract
We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that are characteristic of the C-C and C-X-C chemokines. Ltn is chemotactic for lymphocytes but not for monocytes, a characteristic that makes it unique among chemokines. In addition, calcium flux desensitization studies indicate that Ltn uses a unique receptor. The human Ltn gene maps to a different chromosome than do the C-C and C-X-C chemokine families. Taken together, these characteristics indicate that Ltn is the first example of a new class of human chemokines with preferential effects on lymphocytes.
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Cited by
Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2009 · Cited by 870
Chemokines in pathology and medicine
Baggiolini, M. (2001) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2001.00867.x · Cited by 677
Engelhardt, E., Toksoy, A., Goebeler, M., Debus, S., Bröcker, E.-B., & Gillitzer, R. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65699-4 · Cited by 435
Chemokines: agents for the immunotherapy of cancer?
Homey, B., Müller, A., & Zlotnik, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri748 · Cited by 398
Self-citationChemokine receptors: Structure, function and role in microbial pathogenesis
Murphy, P. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/1359-6101(96)00009-3 · Cited by 320
Metadata
- Authors
- Kennedy, J., Kelner, G. S., Kleyensteuber, S., Schall, T. J., Weiss, M. C., Yssel, H., Schneider, P. V., Cocks, B. G., Bacon, K. B., & Zlotnik, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-07-01
- Volume
- 155
- Issue
- 1
- Pages
- 203-209
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1836438695
- Cited by
- 213
- References
- 0
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kennedy, J., Kelner, G. S., Kleyensteuber, S., Schall, T. J., Weiss, M. C., Yssel, H., Schneider, P. V., Cocks, B. G., Bacon, K. B., & Zlotnik, A. (1995). Molecular cloning and functional characterization of human lymphotactin. The Journal of Immunology. https://doi.org/10.4049/jimmunol.155.1.203
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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