Chemokines: agents for the immunotherapy of cancer?

Dendritic cells and the control of immunity

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Inflammation and cancer: back to Virchow?

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Involvement of chemokine receptors in breast cancer metastasis

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Chemokines

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Lymphocyte Homing and Homeostasis

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Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

Dranoff, G., Jaffee, E. M., Lazenby, A., Golumbek, P. T., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D. M., & Mulligan, R. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3539 · Cited by 2,803 · see citing works

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

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The microenvironment of the tumour–host interface

Liotta, L. A., & Kohn, E. C. (2001) · Nature · doi:10.1038/35077241 · Cited by 2,322 · see citing works

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

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A chemokine-driven positive feedback loop organizes lymphoid follicles

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The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis

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High- and Low-Dose Interferon Alfa-2b in High-Risk Melanoma: First Analysis of Intergroup Trial E1690/S9111/C9190

Kirkwood, J. M., Ibrahim, J. G., Sondak, V. K., Richards, J. M., Flaherty, L. E., Ernstoff, M. S., Smith, T. J., Rao, U., Steele, M., & Blum, R. H. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.12.2444 · Cited by 909 · see citing works

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

Campbell, J. J., Haraldsen, G., Pan, J., Rottman, J. B., Qin, S., Ponath, P. D., Andrew, D. P., Warnke, R. A., Ruffing, N., Kassam, N., et al. (1999) · Nature · doi:10.1038/23495 · Cited by 833 · see citing works

CXC chemokines in angiogenesis

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Overweight as an avoidable cause of cancer in Europe

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Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

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Inhibition of Angiogenesis In Vivo by Interleukin 12

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Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

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Lymphotactin: a Cytokine that Represents a New Class of Chemokine

Kelner, G. S., Kennedy, J., Bacon, K. B., Kleyensteuber, S., Largaespada, D. A., Jenkins, N. A., Copeland, N. G., Bazán, J. F., Moore, K. W., Schall, T. J., et al. (1994) · Science · doi:10.1126/science.7973732 · Cited by 634 · see citing works

Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Induce Expression of CXCR4 on Human Endothelial Cells

Salcedo, R., Wasserman, K., Young, H. A., Grimm, M., Howard, O. M. Z., Anver, M. R., Kleinman, H. K., Murphy, W. J., & Oppenheim, J. J. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65365-5 · Cited by 539 · see citing works

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

Morales, J., Homey, B., Vicari, A. P., Hudak, S. A., Oldham, E. R., Hedrick, J. A., Orozco, R., Copeland, N. G., Jenkins, N. A., McEvoy, L. M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14470 · Cited by 507 · see citing works

Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues

Campbell, D., & Butcher, E. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011502 · Cited by 490 · see citing works

Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium

Nanki, T., Hayashida, K., El-Gabalawy, H. S., Suson, S., Shi, K., Girschick, H. J., Yavuz, S., & Lipsky, P. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6590 · Cited by 450 · see citing works

Alpha and β chemokines induce NK cell migration and enhance NK-mediated cytolysis

Taub, D. D., Sayers, T. J., Carter, C. R., & Ortaldo, J. R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.8.3877 · Cited by 448 · see citing works

The CXC Chemokines Growth-regulated Oncogene (GRO) α, GROβ, GROγ, Neutrophil-activating Peptide-2, and Epithelial Cell-derived Neutrophil-activating Peptide-78 Are Potent Agonists for the Type B, but Not the Type A, Human Interleukin-8 Receptor

Ahuja, S. K., & Murphy, P. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20545 · Cited by 425 · see citing works

Chemokines and the Molecular Basis of Cancer Metastasis

Murphy, P. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200109133451113 · Cited by 415 · see citing works

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

Luster, A. D., & Leder, P. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.1057 · Cited by 413 · see citing works

IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor.

Schadendorf, D., Möller, A., Algermissen, B., Worm, M., Sticherling, M., & Czarnetzki, B. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.5.2667 · Cited by 412 · see citing works

Chemokine Receptors in Human Endothelial Cells

Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E. H., & Stadel, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4282 · Cited by 408 · see citing works

Dendritic Cells as Vectors for Therapy

Banchereau, J., Schuler‐Thurner, B., Palucka, A. K., & Schuler, G. (2001) · Cell · doi:10.1016/s0092-8674(01)00448-2 · Cited by 390 · see citing works

Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.

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Epithelial cancer cell migration: a role for chemokine receptors?

Scotton, C. J., Wilson, J. L., Milliken, D., Stamp, G., & Balkwill, F. R. (2001) · PubMed · Cited by 335 · see citing works

Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)

Homey, B., Wang, W., Soto, H., Buchanan, M. E., Wiesenborn, A., Catron, D., Müller, A., McClanahan, T. K., Dieu‐Nosjean, M., Orozco, R., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3465 · Cited by 332 · see citing works

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

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Dendritic cell biology and regulation of dendritic cell trafficking by chemokines

Caux, C., Aït‐Yahia, S., Chemin, K., de BOUTEILLER, O., Dieu‐Nosjean, M., Homey, B., Massacrier, C., Vanbervliet, B., Zlotnik, A., & Vicari, A. P. (2000) · Springer Seminars in Immunopathology · doi:10.1007/s002810000053 · Cited by 313 · see citing works

Clinical trials of antibody therapy

Glennie, M. J., & Johnson, P. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01669-8 · Cited by 290 · see citing works

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors

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Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity

Biragyn, A., Tani, K., Grimm, M., Weeks, S., & Kwak, L. W. (1999) · Nature Biotechnology · doi:10.1038/6995 · Cited by 278 · see citing works

Eotaxin (CCL11) Induces In Vivo Angiogenic Responses by Human CCR3+ Endothelial Cells

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Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.

Arenberg, D. A., Keane, M. P., DiGiovine, B., Kunkel, S. L., Morris, S. B., Xue, Y. Y., Burdick, M. D., Glass, M. C., Iannettoni, M. D., & Strieter, R. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3145 · Cited by 259 · see citing works

Rituximab (Anti‐CD20) Therapy of B‐Cell Lymphomas: Direct Complement Killing is Superior to Cellular Effector Mechanisms

Harjunpää, Junnikkala, & Meri (2000) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2000.00745.x · Cited by 255 · see citing works

Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.

Inoue, K., Slaton, J. W., Perrotte, P., Davis, D. W., Bruns, C. J., Hicklin, D. J., McConkey, D. J., Sweeney, P., Radinsky, R., & Dinney, C. P. (2000) · PubMed · Cited by 225 · see citing works

Molecular cloning and functional characterization of human lymphotactin

Kennedy, J., Kelner, G. S., Kleyensteuber, S., Schall, T. J., Weiss, M. C., Yssel, H., Schneider, P. V., Cocks, B. G., Bacon, K. B., & Zlotnik, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.1.203 · Cited by 213 · see citing works

Chemokine Receptors CXCR-1/2 Activate Mitogen-activated Protein Kinase via the Epidermal Growth Factor Receptor in Ovarian Cancer Cells

Venkatakrishnan, G., Salgia, R., & Groopman, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6868 · Cited by 211 · see citing works

Combined chemokine and cytokine gene transfer enhances antitumor immunity

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INTERLEUKIN-8 AS AN AUTOCRINE GROWTH FACTOR FOR HUMAN COLON CARCINOMA CELLS IN VITRO

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Secondary Lymphoid Tissue Chemokine Mediates T Cell-Dependent Antitumor Responses In Vivo

Sharma, S. P., Stolina, M., Luo, J., Strieter, R. M., Burdick, M. D., Zhu, L. X., Batra, R. K., & Dubinett, S. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4558 · Cited by 204 · see citing works

Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma

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Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers.

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Diverse Transcriptional Response of CD4+ T Cells to Stromal Cell-Derived Factor (SDF)-1: Cell Survival Promotion and Priming Effects of SDF-1 on CD4+ T Cells

Suzuki, Y., Rahman, M., & Mitsuya, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3064 · Cited by 179 · see citing works

Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer

Jäger, D., Jager, E., & Knuth, A. K. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.9.669 · Cited by 170 · see citing works

Macrophage inflammatory protein 3α transgene attracts dendritic cells to established murine tumors and suppresses tumor growth

Fushimi, T., Kojima, A., Moore, M. A. S., & Crystal, R. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7548 · Cited by 168 · see citing works

Identification and characterization of a novel beta chemokine containing six conserved cysteines

Hedrick, J. A., & Zlotnik, A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1589 · Cited by 161 · see citing works

Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-γ-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy

Narvaiza, I., Mazzolini, G. D., Barajas, M., Duarte, M. C., Zaratiegui, M., Qian, C., Melero, I., & Prìeto, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3112 · Cited by 155 · see citing works

T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy.

Kirk, C. J., Hartigan-O’Connor, D. J., Nickoloff, B. J., Chamberlain, J. S., Giedlin, M. A., Aukerman, L., & Mulé, J. J. (2001) · PubMed · Cited by 154 · see citing works

Antitumor Effects of the Mouse Chemokine 6Ckine/SLC Through Angiostatic and Immunological Mechanisms

Vicari, A. P., Aït‐Yahia, S., Chemin, K., Müeller, A., Zlotnik, A., & Caux, C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1992 · Cited by 153 · see citing works

RANTES Secretion by Gene-Modified Tumor Cells Results in Loss of Tumorigenicity In Vivo: Role of Immune Cell Subpopulations

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The CC Chemokine CKβ-11/MIP-3β/ELC/Exodus 3 Mediates Tumor Rejection of Murine Breast Cancer Cells Through NK Cells

Braun, S. E., Chen, K., Foster, R. G., Kim, C. H., Hromas, R., Kaplan, M. H., Broxmeyer, H. E., & Cornetta, K. G. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4025 · Cited by 126 · see citing works

Cancer Vaccines

Greten, T. F., & Jaffee, E. M. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.3.1047 · Cited by 126 · see citing works

Chemokines in allergy

Homey, B., & Zlotnik, A. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00028-x · Cited by 118 · see citing works

Lymphotactin Gene-Modified Bone Marrow Dendritic Cells Act as More Potent Adjuvants for Peptide Delivery to Induce Specific Antitumor Immunity

Cao, X., Zhang, W., He, L., Xie, Z., Shihua, M., Tao, Q., Yu, Y., Hamada, H., & Wang, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6238 · Cited by 113 · see citing works

Effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells

Miyamoto, M., Shimizu, Y., Okada, K., Kashii, Y., Higuchi, K., & Watanabe, A. (1998) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050503 · Cited by 109 · see citing works

CCR7 Ligands, SLC/6Ckine/Exodus2/TCA4 and CKβ-11/MIP-3β/ELC, Are Chemoattractants for CD56+CD16−NK Cells and Late Stage Lymphoid Progenitors

Kim, C. H., Pelus, L. M., Appelbaum, E. R., Johanson, K., Anzai, N., & Broxmeyer, H. E. (1999) · Cellular Immunology · doi:10.1006/cimm.1999.1483 · Cited by 106 · see citing works

Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration

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Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models

Emtage, P. C. R., Wan, Y., Hitt, M., Graham, F. L., Muller, W. J., Zlotnik, A., & Gauldie, J. (1999) · Human Gene Therapy · doi:10.1089/10430349950018463 · Cited by 103 · see citing works

Effects of MGSA/GRO alpha on melanocyte transformation.

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Expression of theJE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells

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I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo

Bernardini, G., Spinetti, G., Ribatti, D., Camarda, G., Morbidelli, L., Ziche, M., Santoni, A., Capogrossi, M. C., & Napolitano, M. (2000) · Blood · doi:10.1182/blood.v96.13.4039 · Cited by 93 · see citing works

Interleukin-2 in cancer treatment: Disappointing or (still) promising? A review

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Tumor Rejection and Immune Memory Elicited by Locally Released LEC Chemokine Are Associated with an Impressive Recruitment of APCs, Lymphocytes, and Granulocytes

Giovarelli, M., Cappello, P., Forni, G., Salcedo, T. W., Moore, P. A., LeFleur, D. W., Nardelli, B., Carlo, E. D., Lollini, P., Ruben, S. M., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3200 · Cited by 86 · see citing works

Inhibition of in vivo tumor growth by the beta chemokine, TCA3.

Laning, J. C., Kawasaki, H., Tanaka, E., Luo, Y., & Dorf, M. E. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.10.4625 · Cited by 82 · see citing works

Regulatable systems: applications in gene therapy and replicating viruses.

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Expression of interleukin-8 in primary and metastatic malignant melanoma of the skin

Singh, R. K., Varney, M. L., Bucana, C. D., & Johansson, S. L. (1999) · Melanoma Research · doi:10.1097/00008390-199908000-00007 · Cited by 78 · see citing works

Lymphotactin Expression by Engineered Myeloma Cells Drives Tumor Regression: Mediation by CD4+ and CD8+ T Cells and Neutrophils Expressing XCR1 Receptor

Cairns, C. M., Gordon, J., Li, F., Baca‐Estrada, M. E., Moyana, T. N., & Xiang, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.57 · Cited by 74 · see citing works

A Candidate for Cancer Gene Therapy: MIP-lα Gene Transfer to an Adenocarcinoma Cell Line Reduced T\imorigenicity and Induced Protective Immunity in Immunocompetent Mice

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Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity

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Human MCAF Gene Transfer Enhances the Metastatic Capacity of a Mouse Cachectic Adenocarcinoma Cell Line in Vivo

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Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma

Zeelenberg, I. S., Stalle, L. R.-V., & Roos, E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11330 · Cited by 62 · see citing works

MIG (CXCL9) chemokine gene therapy combines with antibody-cytokine fusion protein to suppress growth and dissemination of murine colon carcinoma.

Ruehlmann, J. M., Xiang, R., Niethammer, A. G., Ba, Y., Pertl, U., Dolman, C. S., Gillies, S. D., & Reisfeld, R. (2001) · PubMed · Cited by 59 · see citing works

Immunomodulatory Functions and Molecular Regulation of IL-12

Ma, X., Aste-Amézaga, M., Gri, G., Gerosa, F., & Trinchieri, G. (1997) · KARGER eBooks · doi:10.1159/000058687 · Cited by 52 · see citing works

Advances in cancer immunotherapy

Ockert, D., Schmitz, M., Hampl, M., & Rieber, E. P. (1999) · Immunology Today · doi:10.1016/s0167-5699(98)01388-7 · Cited by 49 · see citing works

Expression of cyclin D2 and D3 in lymphoid lesions

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