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Blood clearance kinetics and liver uptake of mononucleosomes in mice
Abstract
Nucleosomes generated by apoptosis have become of considerable interest in relation to pathogenesis of systemic lupus erythematosus in mice and humans. Therefore, the fate of circulating mononucleosomes was examined in normal C57Bl/6J mice. The mononucleosomes were prepared from chicken erythrocytes and radiolabeled on the histone component. The removal of nucleosomes from circulation at doses less than 11 micrograms of injected mononucleosomes was rapid, but with increasing doses of injected nucleosomes, the slopes of the removal curves decreased. Liver was the major organ for removal of circulating nucleosomes, accounting for 71.0 to 84.7% of nucleosomes removed from circulation at 10 min. After i.v. injection of nucleosomes, 0.52 +/- 0.15% localized in kidneys. With prior i.v. injection of histones, the glomerular localization of mononucleosomes increased threefold. The clearance of mononucleosomes was decreased sixfold by concurrent injection of ssDNA. These studies show that in mice, circulating mononucleosomes are handled similar to DNA, and they do not avidly localize in glomeruli unless histones have already bound to renal glomeruli.
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Metadata
- Authors
- Gauthier, V. J., Tyler, L. N., & Mannik, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-02-01
- Volume
- 156
- Issue
- 3
- Pages
- 1151-1156
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1496811300
- Cited by
- 175
- References
- 0
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Blood clearance kinetics and liver uptake of mononucleosomes in mice. https://app.cochat.ai/papers/10.4049/jimmunol.156.3.1151
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- Gauthier, V. J., Tyler, L. N., & Mannik, M. (1996). Blood clearance kinetics and liver uptake of mononucleosomes in mice. The Journal of Immunology. https://doi.org/10.4049/jimmunol.156.3.1151
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
