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Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro
Abstract
The present study was performed to characterize the immunologic potential of interstitial macrophages (INT) in comparison with alveolar macrophages (AL). The data showed that AL, compared with INT, have a more efficient phagocytic potential. In addition, they have a strong microbicidal activity and secrete large amounts of reactive oxygen radicals, nitric oxides, TNF, and IFN on appropriate stimulation. They also exert strong tumoricidal and parasiticidal activities. In contrast, INT are more efficient in releasing immunoregulatory cytokines such as IL-1 and IL-6. As determined by Ab staining, INT express more MHC class II molecules and are more effective in functioning as accessory cells for mitogen-stimulated lymphocyte proliferation compared with AL. Thus, AL appear to be particularly effective as nonspecific first line defense cells against infectious agents, whereas INT are equipped to cooperate with interstitial lymphocytes in inducing a specific immune reaction.
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“Among host innate immune players, resident alveolar macrophages (AMs) are considered to be the most important first line of defense against respiratory pneumococcal infections (13), through their high phagocytic capacity (14–16).”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [14]
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Byrne, A. J., Mathie, S. A., Gregory, L. G., & Lloyd, C. M. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207020 · Cited by 499
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39717 · Cited by 399
Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections
Ghoneim, H. E., Thomas, P. G., & McCullers, J. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300014 · Cited by 394
“These differences reflect the spatial and functional differences between the two major subsets of lung-resident macrophages, with IMs having less accessibility to the intranasally administered dye and lower phagocytic capacity than AMs (14, 24, 31).”
BackgroundUpdate on Macrophage Clearance of Inhaled Micro- and Nanoparticles
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Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?
Byrne, A. J., Maher, T. M., & Lloyd, C. M. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.02.004 · Cited by 326
“Global IL-10 knockout mice are also protected from silica or bleomycin-induced fibrosis [99].”
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Metadata
- Authors
- Franke-Ullmann, G., Pförtner, C., Walter, P., Steinmüller, C., Lohmann-Matthes, M. L., & Kobzik, L.
- Affiliations
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- ORCID
- Kobzik, L
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-10-01
- Volume
- 157
- Issue
- 7
- Pages
- 3097-3104
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1539936851
- Cited by
- 160
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 7 · 2013: 12 · 2012: 5
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- interstitial macrophages, alveolar macrophages, lung macrophages, phagocytosis, microbicidal activity, reactive oxygen radicals, nitric oxide, TNF-α, interferon, immunoregulatory cytokines, MHC class II, accessory cells, lymphocyte proliferation, innate immunity, adaptive immunity, mouse lung
- MeSH terms
- Interleukin-6 Inhibitors, Animals, Antigen-Presenting Cells, Cells, Cultured, Female, Interferons, Interleukin-1, L Cells, Leishmania donovani, Lung, Macrophage Activation, Macrophages, Mice, Inbred BALB C, Phagocytosis, Mast-Cell Sarcoma, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Interleukin-6, Macrophages, Alveolar, Reactive Oxygen Species, Mice
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