Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
Open accessAbstract
The respiratory tract is continuously exposed to both innocuous airborne antigens and immunostimulatory molecules of microbial origin, such as LPS. At low concentrations, airborne LPS can induce a lung DC-driven Th2 cell response to harmless inhaled antigens, thereby promoting allergic asthma. However, only a small fraction of people exposed to environmental LPS develop allergic asthma. What prevents most people from mounting a lung DC-driven Th2 response upon exposure to LPS is not understood. Here we have shown that lung interstitial macrophages (IMs), a cell population with no previously described in vivo function, prevent induction of a Th2 response in mice challenged with LPS and an experimental harmless airborne antigen. IMs, but not alveolar macrophages, were found to produce high levels of IL-10 and to inhibit LPS-induced maturation and migration of DCs loaded with the experimental harmless airborne antigen in an IL-10-dependent manner. We further demonstrated that specific in vivo elimination of IMs led to overt asthmatic reactions to innocuous airborne antigens inhaled with low doses of LPS. This study has revealed a crucial role for IMs in maintaining immune homeostasis in the respiratory tract and provides an explanation for the paradox that although airborne LPS has the ability to promote the induction of Th2 responses by lung DCs, it does not provoke airway allergy under normal conditions.
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Strategies for differentiation of resident macrophage subsets in the airways and lung tissues are insufficient to distinguish alveolar macrophages from lung interstitial macrophages or inflammatory monocytic cells invading the lung in response to infections.
“However, the strategies for differentiation of resident macrophage subsets in the airways and lung tissues are insufficient to distinguish AMs from lung interstitial macrophages or inflammatory monocytic cells invading the lung in response to infections.”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [19]
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- Authors
- Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., de Leval, L., Van Rooijen, N., Le Moine, A., Vanderplasschen, A., Cataldo, D., Drion, P.-V., Moser, M., Lekeux, P., & Bureau, F.
- Affiliations
- University of Liège (BE)
- Université Libre de Bruxelles (BE)
- Corresponding author
- Bureau, Fabrice
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2009-12-01
- Volume
- 119
- Issue
- 12
- Pages
- 3723-3738
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2786798
- OpenAlex
- W2132967213
- Cited by
- 399
- References
- 70
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 18 · 2023: 26 · 2022: 27 · 2021: 29 · 2020: 26 · 2019: 22 · 2018: 29 · 2017: 30 · 2016: 26 · 2015: 29 · 2014: 23 · 2013: 31 · 2012: 20
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- Fédération Wallonie-Bruxelles
- Université de Liège
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- lung interstitial macrophages, dendritic cells, airway allergy, allergic asthma, lipopolysaccharide, Th2 immune response, IL-10, dendritic cell maturation, dendritic cell migration, immune homeostasis, respiratory tract, alveolar macrophages
- MeSH terms
- Allergens, Amino Acid Sequence, Animals, Asthma, Cell Differentiation, Cell Movement, Dendritic Cells, Immunity, Innate, Lipopolysaccharides, Lung, Macrophages, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Ovalbumin, Peptide Fragments, Macrophages, Alveolar, Interleukin-10, Mice, Knockout, Th2 Cells, Toll-Like Receptor 4, Mice, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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