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Expanded CD4+ and CD8+ T cell clones in elderly humans
Abstract
The diversity of the human TCR repertoire in aging has been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expressed by the BV families. The TCRBV CDR3 profile, which shows size heterogeneity in young adult humans, is significantly restricted in aged humans. Clonal T cell expansions were identified using a PCR-based approach, in one or more BV families from all 14 healthy persons over the age of 65 that we studied. CD4+ T cell expansions were identified in 8 of 11 donors and CD8+ T cell expansions in 7 of 10 donors. These clonal expansions were stable during a 2-year period. Interestingly, more than half of the aged persons had clonal expansions within the BV3, -14, -16, and -23 families. Although there was no homology among the eight CDR3 sequences identified in clonal T cells from 8 aged persons, selective pressure on the expanded T cell clones was suggested by the fact that the BV families used by the T cell clones were not proportional to the number of genes in the different BV families.
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Cited by
Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.393 · Cited by 951
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Yager, E. J., Ahmed, M., Lanzer, K., Randall, T. D., Woodland, D. L., & Blackman, M. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071140 · Cited by 490
Pulmonary Nontuberculous Mycobacterial Disease: Prospective Study of a Distinct Preexisting Syndrome
Kim, R. D., Greenberg, D. E., Ehrmantraut, M. E., Guide, S. V., Ding, L., Shea, Y., Brown, M. R., Chernick, M., Steagall, W. K., Glasgow, C. G., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200805-686oc · Cited by 444
Metadata
- Authors
- Schwab, R., Szabo, P., Manavalan, J. S., Weksler, M. E., Posnett, D. N., Pannetier, C., Kourilsky, P., & Even, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-05-01
- Volume
- 158
- Issue
- 9
- Pages
- 4493-4499
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1581000856
- Cited by
- 291
- References
- 0
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwab, R., Szabo, P., Manavalan, J. S., Weksler, M. E., Posnett, D. N., Pannetier, C., Kourilsky, P., & Even, J. (1997). Expanded CD4+ and CD8+ T cell clones in elderly humans. The Journal of Immunology. https://doi.org/10.4049/jimmunol.158.9.4493
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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