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Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response
Abstract
Female SJL mice are more susceptible than male mice to experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (MBP)-specific T lymphocytes. In the present study, we examined mechanisms involved in this gender-related difference in disease susceptibility. MBP-specific T lymphocytes derived from spleens of males during the effector phase of adoptive EAE produced significantly higher levels of IL-10, an anti-inflammatory cytokine in EAE. A protective effect of testosterone was then shown. Females implanted with dihydrotestosterone pellets demonstrated a significantly less severe course of EAE as compared with females implanted with placebo pellets. Finally, MBP-specific T lymphocytes derived from dihydrotestosterone-implanted females produced significantly higher levels of IL-10 than those from placebo. Together these data indicate that testosterone exerts a protective effect in EAE that is mediated at least in part by enhanced production of IL-10 by autoantigen-specific T lymphocytes.
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Cited by
Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731
Suppressive effects of androgens on the immune system
Trigunaite, A., Dimo, J., & Jørgensen, T. N. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.004 · Cited by 551
Estriol ameliorates autoimmune demyelinating disease: Implications for multiple sclerosis
Kim, S., Liva, S. M., Dalal, M. A., Verity, M. A., & Voskuhl, R. R. (1999) · Neurology · doi:10.1212/wnl.52.6.1230 · Cited by 268
Self-citationFemale sex steroids: effects upon microglial cell activation
Drew, P. D., & Chavis, J. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00386-6 · Cited by 209
Androgens and Estrogens Modulate the Immune and Inflammatory Responses in Rheumatoid Arthritis
CUTOLO, M., SERIOLO, B., VILLAGGIO, B., PIZZORNI, C., CRAVIOTTO, C., & SULLI, A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04210.x · Cited by 194
Metadata
- Authors
- Dalal, M., Kim, S., & Voskuhl, R. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-07-01
- Volume
- 159
- Issue
- 1
- Pages
- 3-6
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2161154771
- Cited by
- 293
- References
- 0
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dalal, M., Kim, S., & Voskuhl, R. R. (1997). Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response. The Journal of Immunology. https://doi.org/10.4049/jimmunol.159.1.3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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