The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member
Abstract
Human CD38 is a cell surface molecule involved in the regulation of lymphocyte adhesion to endothelial cells. This suggests that HUVEC bear a ligand(s) for CD38 on the cell surface. By means of the mAb Moon-1, which specifically inhibits CD38-mediated cell adhesion, we have identified a trans-membrane 130-kDa molecule acting as a ligand for CD38. Here, we report that the molecule recognized by the Moon-1 mAb is CD31, a member of the Ig superfamily. This conclusion is based on 1) cross-inhibition assays between Moon-1 and reference anti-CD31 mAbs; 2) sequential immunoprecipitation experiments using Moon-1 and known anti-CD31 mAbs, and 3) reactivity of the Moon-1 mAb with CD31 transfectants. Further, CD31 and CD38 cognate interactions were found to modulate heterotypic adhesion as well as to implement cytoplasmic calcium fluxes identical to those obtained by means of agonistic anti-CD38 mAbs. Other effects tested included the synthesis of messages for a panel of cytokines, markedly increased upon receptor-ligand interactions. These results suggest that the interplay between CD38 and its ligand CD31 is an important step in the regulation of cell life and of the migration of leukocytes (and CD38+ cancer cells) through the endothelial cell wall.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
PECAM-1 is required for transendothelial migration of leukocytes.
Muller, W. A., Weigl, S. A., Deng, X., & Phillips, D. M. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.2.449 · Cited by 1,152
PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily
Newman, P. J., Berndt, M. C., Gorski, J., White, G. C., Lyman, S., Paddock, C., & Muller, W. A. (1990) · Science · doi:10.1126/science.1690453 · Cited by 950
Warrell, R. P., de The, H., Wang, Z.-Y., & Degos, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307153290307 · Cited by 776
Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38
Howard, M., Grimaldi, J. C., Bazan, J. F., Lund, F. E., Santos-Argumedo, L., Parkhouse, R. M. E., Walseth, T. F., & Lee, H. C. (1993) · Science · doi:10.1126/science.8235624 · Cited by 736
Structural Determination of a Cyclic Metabolite of NAD+ with Intracellular Ca2+-mobilizing Activity
Lee, H. C., Walseth, T. F., Bratt, G. T., Hayes, R. N., & Clapper, D. L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94230-4 · Cited by 480
Piali, L., Hammel, P., Uherek, C., Bachmann, F., Gisler, R. H., Dunon, D., & Imhof, B. A. (1995) · The Journal of cell biology · doi:10.1083/jcb.130.2.451 · Cited by 376
Human CD38: a glycoprotein in search of a function
Malavasi, F., Funaro, A., Roggero, S., Horenstein, A., Calosso, L., & Mehta, K. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90148-1 · Cited by 345
Self-citationMolecular and functional aspects of PECAM-1/CD31
DeLisser, H. M., Newman, P. J., & Albelda, S. M. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90195-3 · Cited by 312
Human CD38, a cell‐surface protein with multiple functions
Mehta, K., Shahid, U., & Malavasi, F. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.12.8903511 · Cited by 295
Self-citation
Cited by
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617
Chiorazzi, N., Rai, K. R., & Ferrarini, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041720 · Cited by 1,296
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862
Self-citationPECAM-1: regulator of endothelial junctional integrity
Privratsky, J. R., & Newman, P. J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-013-1779-3 · Cited by 366
Monoclonal antibodies targeting CD 38 in hematological malignancies and beyond
van de Donk, N. W. C. J., Janmaat, M. L., Mutis, T., Lammerts van Bueren, J. J., Ahmadi, T., Sasser, A. K., Lokhorst, H. M., & Parren, P. W. H. I. (2016) · Immunological Reviews · doi:10.1111/imr.12389 · Cited by 353
Metadata
- Authors
- Deaglio, S., Morra, M., Mallone, R., Ausiello, C. M., Prager, E., Garbarino, G., Dianzani, U., Stockinger, H., & Malavasi, F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 160
- Issue
- 1
- Pages
- 395-402
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313379456
- Cited by
- 389
- References
- 35
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member. https://app.cochat.ai/papers/10.4049/jimmunol.160.1.395
- The paper
- Deaglio, S., Morra, M., Mallone, R., Ausiello, C. M., Prager, E., Garbarino, G., Dianzani, U., Stockinger, H., & Malavasi, F. (1998). Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member. The Journal of Immunology. https://doi.org/10.4049/jimmunol.160.1.395
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
