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Cited by 788

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile

Open access
Prescott, Susan L, Macaubas, Claudia, Holt, Barbara J, Smallacombe, Troy B, Loh, Richard, Sly, Peter D, Holt, Patrick G·1998·The Journal of Immunology
DOI 10.4049/jimmunol.160.10.4730
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Abstract

The expression of Th2-skewed immunity against soluble protein Ags present in the normal environment is recognized as the primary cause of allergic inflammation in atopics. In contrast, nonallergic normal individuals display low level Th1-skewed immunity against the same Ags (“allergens”), which is perceived as conferring protection against Th2-dependent allergic sensitization. The type of T cell memory that develops against these Ags is currently believed to be the result of complex interactions between environmental and genetic susceptibility factors, which occur postnatally when the naive immune system directly confronts the outside environment. The results of the present study challenge this general concept. We demonstrate here for the first time that Th2-skewed responses to common environmental allergens, comprising IL-4, IL-5, IL-6, IL-9, and IL-13, are present in virtually all newborn infants and are dominated by high level production of IL-10. Moreover, these responses are demonstrable within 24 h of culture initiation, arguing against a significant contribution from covert in vitro T cell priming and/or differentiation. These findings imply that the key etiologic factor in atopic disease may not be the initial acquisition of allergen-specific Th2-skewed immunity per se, but instead may be the efficiency of immune deviation mechanisms, which in normal (nonatopic) individuals redirect these fetal immune responses toward the Th1 cytokine phenotype.

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Metadata

Authors
Prescott, S. L., Macaubas, C., Holt, B. J., Smallacombe, T. B., Loh, R., Sly, P. D., & Holt, P. G.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
1998-05
Volume
160
Issue
10
Pages
4730-4737
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.160.10.4730
OpenAlex
W1487602178
Cited by
788
References
46
FWCI
33.12
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile. https://app.cochat.ai/papers/10.4049/jimmunol.160.10.4730
The paper
Prescott, S. L., Macaubas, C., Holt, B. J., Smallacombe, T. B., Loh, R., Sly, P. D., & Holt, P. G. (1998). Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile. The Journal of Immunology. https://doi.org/10.4049/jimmunol.160.10.4730

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.