The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cutting Edge: Cytokine-Dependent Abortion in CBA × DBA/2 Mice Is Mediated by the Procoagulant fgl2 Prothombinase
Open accessAbstract
Spontaneous resorption in the CBA × DBA/2 model is attributed to NK cells, macrophages, and Th1-type cytokines. In vivo depletion of NK cells by anti-asialoGM1 Ab or macrophage depletion by silicon dioxide treatment reduced abortion rates, which could no longer be boosted by injecting TNF-α (which activates NK cells) or IFN-γ (which activates macrophages). TNF-α + γ-IFN coadministration aborted >80% of the embryos whether or not NK cells or macrophages had been depleted or estradiol + progesterone was injected to correct potential reduction in ovarian function by cytokines. The cytokines also aborted IRF1+/+ C57BL/6 but not IRF1−/− females pregnant by IRF1+/+ DBA/2. Both spontaneous and cytokine-boosted abortions in CBA × DBA/2 were blocked by Ab to fgl2 prothombinase expressed by cytokine-stimulated vascular endothelial cells and monocytes; in vivo Ab depletion of granulocytes also prevented TNF-α + IFN-γ-induced abortions. Cytokine-triggered thrombotic/inflammatory processes in maternal uteroplacental blood vessels causes abortion.
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Citations
Cites
Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha
Doherty, G. M., Lange, J. R., Langstein, H. N., Alexander, H. R., Buresh, C. M., & Norton, J. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.5.1666 · Cited by 300
Cited by
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
Girardi, G., Berman, J., Redecha, P., Spruce, L., Thurman, J. M., Kraus, D., Hollmann, T. J., Casali, P., Caroll, M. C., Wetsel, R. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318817 · Cited by 594
Girardi, G., Yarilin, D., Thurman, J. M., Holers, V. M., & Salmon, J. E. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061022 · Cited by 508
The role of infection in miscarriage
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E. M., & Horne, A. W. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv041 · Cited by 464
Progesterone and the immunology of pregnancy
Druckmann, R., & Druckmann, M.-A. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.08.010 · Cited by 306
Malaria parasitemia and systemic cytokine bias in pregnancy
Achidi, E. A., Apinjoh, T. O., & Titanji, V. P. K. (2007) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2006.12.015 · Cited by 22
Metadata
- Authors
- Clark, D. A., Chaouat, G., Arck, P. C., Mittruecker, H. W., & Levy, G. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01
- Volume
- 160
- Issue
- 2
- Pages
- 545-549
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313377193
- Cited by
- 265
- References
- 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cutting Edge: Cytokine-Dependent Abortion in CBA × DBA/2 Mice Is Mediated by the Procoagulant fgl2 Prothombinase. https://app.cochat.ai/papers/10.4049/jimmunol.160.2.545
- The paper
- Clark, D. A., Chaouat, G., Arck, P. C., Mittruecker, H. W., & Levy, G. A. (1998). Cutting Edge: Cytokine-Dependent Abortion in CBA × DBA/2 Mice Is Mediated by the Procoagulant fgl2 Prothombinase. The Journal of Immunology. https://doi.org/10.4049/jimmunol.160.2.545
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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