The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activation Polypeptide (PACAP) Protect Mice from Lethal Endotoxemia Through the Inhibition of TNF-α and IL-6
Open accessAbstract
The neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) down-regulate cytokine production. Because human septic shock involves excessive cytokine production, the effect of VIP/PACAP was investigated in a high endotoxemia murine model. Both peptides protect against endotoxin-induced lethality and prevent septic shock-associated histopathological alterations. VIP/PACAP reduce serum and peritoneal TNF-α and IL-6, suggesting that the protective effect is exerted by inhibiting the production of endogenous TNF-α/IL-6. Consistent with this mechanism, VIP does not protect against septic shock induced by exogenous TNF-α. The immunomodulatory role of VIP in vivo is supported by the appearance of high levels of VIP in serum and peritoneal fluid following LPS administration. Thus, the neuropeptides VIP/PACAP protect from the lethal effect of high endotoxemia, presumably by down-regulating TNF-α and IL-6 production, and may offer an alternative in the treatment of human septic shock syndrome.
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Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677
Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha
Doherty, G. M., Lange, J. R., Langstein, H. N., Alexander, H. R., Buresh, C. M., & Norton, J. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.5.1666 · Cited by 300
Cited by
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
Vaudry, D., Gonzalez, B. J., Basille, M., Yon, L., Fournier, A., & Vaudry, H. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01449-2 · Cited by 1,121
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665
Abad, C., Martinez, C., Juarranz, M. G., Arranz, A., Leceta, J., Delgado, M., & Gomariz, R. P. (2003) · Gastroenterology · doi:10.1053/gast.2003.50141 · Cited by 257
Self-citationCarrillo‐Vico, A., Lardone, P. J., Naji, L., Fernández‐Santos, J. M., Martín‐Lacave, I., Guerrero, J. M., & Calvo, J. R. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00265.x · Cited by 204
Self-citationDelgado, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00283-8 · Cited by 53
Metadata
- Authors
- Delgado, M., Martinez, C., Pozo, D., Calvo, J. R., Leceta, J., Ganea, D., & Gomariz, R. P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 162
- Issue
- 2
- Pages
- 1200-1205
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313331694
- Cited by
- 184
- References
- 4
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activation Polypeptide (PACAP) Protect Mice from Lethal Endotoxemia Through the Inhibition of TNF-α and IL-6. https://app.cochat.ai/papers/10.4049/jimmunol.162.2.1200
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- Delgado, M., Martinez, C., Pozo, D., Calvo, J. R., Leceta, J., Ganea, D., & Gomariz, R. P. (1999). Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activation Polypeptide (PACAP) Protect Mice from Lethal Endotoxemia Through the Inhibition of TNF-α and IL-6. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.2.1200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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