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Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus.
Open accessAbstract
The inactivated poliovirus vaccine (IPV) is used for protection against poliomyelitis in The Netherlands. It is not clear, however, whether IPV vaccination can lead to priming of the mucosal immune system and the induction of IgA. It has been demonstrated that IPV vaccination is able to induce strong memory IgA responses in the serum of persons who have been naturally exposed to wild-type poliovirus. This has led to the hypothesis that IPV vaccination is able to induce poliovirus-specific IgA at mucosal sites in persons who have been previously primed with live poliovirus at mucosal sites. To test this hypothesis, the kinetics of the IgA response in serum and saliva after IPV vaccination were examined in persons previously vaccinated with oral poliovirus vaccine (OPV) or IPV. ELISA and enzyme-linked immunospot assays were used for the detection of poliovirus-specific IgA responses. In addition, B cell populations were separated on the basis of the expression of mucosal (α4β7 integrin) and peripheral homing receptors (L-selectin). Parenteral IPV vaccination was able to boost systemic and mucosal IgA responses in previously OPV-vaccinated persons only. None of the previously vaccinated IPV recipients responded with the production of IgA in saliva. In agreement with this finding, a large percentage of the poliovirus-specific IgA-producing lymphocytes detected in previous OPV recipients expressed the α4β7 integrin. It is concluded that IPV vaccination alone is insufficient to induce a mucosal IgA response against poliovirus. In mucosally (OPV-) primed individuals, however, booster vaccination with IPV leads to a strong mucosal IgA response.
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“The impact of IPV in these studies is perhaps more likely to relate to local immunity induced by IPV through transudation of serum IgG rather than induction of a local secretory IgA response [7].”
From Systematic Review of Mucosal Immunity Induced by Oral and Inactivated Poliovirus Vaccines against Virus Shedding following Oral Poliovirus Challenge (2012) · cites this paper as [7]
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“However, IPV can induce gut-homing lymphocytes and an increase in the secretion of poliovirus-specific IgA among individuals who have been previously exposed to live-attenuated or wild-type poliovirus [6], [7].”
From Systematic Review of Mucosal Immunity Induced by Oral and Inactivated Poliovirus Vaccines against Virus Shedding following Oral Poliovirus Challenge (2012) · cites this paper as [7]
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Metadata
- Authors
- Herremans, T. M. P. T., Reimerink, J. H. J., Buisman, A. M., Kimman, T. G., & Koopmans, M. P. G.
- Affiliations
- National Institute for Public Health and the Environment (NL)
- Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment (RIVM) , Bilthoven ,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-04
- Volume
- 162
- Issue
- 8
- Pages
- 5011-5018
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2109715645
- Cited by
- 149
- References
- 29
- Citations by year
- 2026: 4 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 11 · 2012: 6
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- inactivated poliovirus vaccine, oral polio vaccine, mucosal immunity, IgA, alpha4beta7 integrin, L-selectin, B cell homing, booster vaccination, saliva IgA, poliomyelitis
- MeSH terms
- Adult, Antibodies, Viral, Antibody Specificity, Antibody-Producing Cells, Binding Sites, Antibody, Feces, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunization, Secondary, Poliomyelitis, Poliovirus Vaccine, Inactivated, Saliva, Secretory Component, Vaccines, Inactivated, Poliovirus, Immunity, Mucosal
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