The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)
Abstract
CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to direct stimulation through the TCR with monoclonal anti-CD3ε Ab. CD134-deficient mice controlled infection with Leishmania major, Nippostrongylus brasiliensis, and Theiler’s murine encephalomyelitis virus, and they made overtly normal Ab responses to a variety of antigens. Thus, CD134 is not essential for many T cell responses in vivo, nor is it required for the provision of help to B cells. Nonetheless, a subtle role in the regulation of T cell reactivity is suggested by the effect of CD134 deficiency on in vitro T cell responses.
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Cites
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Flynn, S., Toellner, K.-M., Raykundalia, C., Goodall, M., & Lane, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.297 · Cited by 351
Cited by
TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES
Watts, T. H. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115839 · Cited by 1,353
Valzasina, B., Guiducci, C., Dislich, H., Killeen, N., Weinberg, A. D., & Colombo, M. P. (2005) · Blood · doi:10.1182/blood-2004-07-2959 · Cited by 428
Self-citationOX40 costimulation turns off Foxp3+ Tregs
Vu, M. D., Xiao, X., Gao, W., Degauque, N., Chen, M., Kroemer, A., Killeen, N., Ishii, N., & Chang Li, X. (2007) · Blood · doi:10.1182/blood-2007-01-070748 · Cited by 428
Self-citationGramaglia, I., Jember, A., Pippig, S. D., Weinberg, A. D., Killeen, N., & Croft, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3043 · Cited by 409
Self-citationGri, G., Piconese, S., Frossi, B., Manfroi, V., Merluzzi, S., Tripodo, C., Viola, A., Odom, S., Rivera, J., Colombo, M. P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.018 · Cited by 391
Metadata
- Authors
- Pippig, S. D., Peña-Rossi, C., Long, J., Godfrey, W. R., Fowell, D. J., Reiner, S. L., Birkeland, M. L., Locksley, R. M., Barclay, A. N., & Killeen, N.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-12
- Volume
- 163
- Issue
- 12
- Pages
- 6520-6529
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2137639957
- Cited by
- 163
- References
- 2
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Pippig, S. D., Peña-Rossi, C., Long, J., Godfrey, W. R., Fowell, D. J., Reiner, S. L., Birkeland, M. L., Locksley, R. M., Barclay, A. N., & Killeen, N. (1999). Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40). The Journal of Immunology. https://doi.org/10.4049/jimmunol.163.12.6520
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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