The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
APCs Express DCIR, a Novel C-Type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif
Open accessAbstract
We have identified a novel member of the calcium-dependent (C-type) lectin family. This molecule, designated DCIR (for dendritic cell (DC) immunoreceptor), is a type II membrane glycoprotein of 237 aa with a single carbohydrate recognition domain (CRD), closest in homology to those of the macrophage lectin and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR contains a consensus immunoreceptor tyrosine-based inhibitory motif. A mouse cDNA, encoding a homologous protein has been identified. Northern blot analysis showed DCIR mRNA to be predominantly transcribed in hematopoietic tissues. The gene encoding human DCIR was localized to chromosome 12p13, in a region close to the NK gene complex. Unlike members of this complex, DCIR displays a typical lectin CRD rather than an NK cell type extracellular domain, and was expressed on DC, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR was strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. DCIR was mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34+ progenitor cells. Finally, DCIR expression was down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-α. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation. DCIR represents a novel surface molecule expressed by Ag presenting cells, and of potential importance in regulation of DC function.
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Cited by
Valladeau, J., Ravel, O., Dezutter-Dambuyant, C., Moore, K., Kleijmeer, M., Liu, Y., Duvert-Frances, V., Vincent, C., Schmitt, D., Davoust, J., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80160-0 · Cited by 962
Self-citationDC-SIGN: escape mechanism for pathogens
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C-type lectin receptors on dendritic cells and langerhans cells
Figdor, C. G., van Kooyk, Y., & Adema, G. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri723 · Cited by 842
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Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Brière, F., Vlach, J., Lebecque, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2942 · Cited by 435
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Metadata
- Authors
- Bates, E. E. M., Fournier, N., Garcia, E., Valladeau, J., Durand, I., Pin, J.-J., Zurawski, S. M., Patel, S., Abrams, J. S., Lebecque, S., Garrone, P., & Saeland, S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 163
- Issue
- 4
- Pages
- 1973-1983
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1550634531
- Cited by
- 269
- References
- 70
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bates, E. E. M., Fournier, N., Garcia, E., Valladeau, J., Durand, I., Pin, J.-J., Zurawski, S. M., Patel, S., Abrams, J. S., Lebecque, S., Garrone, P., & Saeland, S. (1999). APCs Express DCIR, a Novel C-Type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif. The Journal of Immunology. https://doi.org/10.4049/jimmunol.163.4.1973
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