The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses
Abstract
4-1BB (CD137) is a costimulatory molecule expressed on activated T cells and interacts with 4-1BB ligand (4-1BBL) on APCs. To investigate the role of 4-1BB costimulation for the development of primary immune responses, 4-1BBL-deficient (4-1BBL−/−) mice were infected with lymphocytic choriomeningitis virus (LCMV). 4-1BBL−/− mice were able to generate CTL and eliminate acute LCMV infection with normal kinetics, but CD8 T cell expansion was 2- to 3-fold lower than in wild-type (+/+) mice. In the same mice, virus-specific CD4 Th and B cell responses were minimally affected, indicating that 4-1BB costimulation preferentially affects CD8 T cell responses. This result contrasts with our earlier work with CD40L-deficient (CD40L−/−) mice, in which the CD8 T cell response was unaffected and the CD4 T cell response was markedly impaired. When both 4-1BBL- and B7-dependent signals were absent, CD8 T cell expansion was further reduced, resulting in lower CTL activity and impairing their ability to clear LCMV. Altogether, these results indicate that T cells have distinct costimulatory requirements: optimal CD8 responses require 4-1BBL-dependent interactions, whereas CD4 responses are minimally affected by 4-1BB costimulation, but require CD40-CD40L and B7-dependent interactions.
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Cites
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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
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Cited by
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Self-citationGramaglia, I., Jember, A., Pippig, S. D., Weinberg, A. D., Killeen, N., & Croft, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3043 · Cited by 409
Metadata
- Authors
- Tan, J. T., Whitmire, J. K., Ahmed, R., Pearson, T. C., & Larsen, C. P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11-01
- Volume
- 163
- Issue
- 9
- Pages
- 4859-4868
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1487003048
- Cited by
- 259
- References
- 50
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses. https://app.cochat.ai/papers/10.4049/jimmunol.163.9.4859
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- Tan, J. T., Whitmire, J. K., Ahmed, R., Pearson, T. C., & Larsen, C. P. (1999). 4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses. The Journal of Immunology. https://doi.org/10.4049/jimmunol.163.9.4859
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