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T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds
Abstract
The requirements for T cell activation have been reported to vary widely depending on the state of the T cell, the type of antigen-presenting cell, and the nature of the T cell receptor (TCR) ligand. A unitary requirement for T cell responses was revealed by measurement of the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells "counted" the number of triggered TCRs and responded when a threshold of ∼8000 TCRs was reached. The capacity to reach the activation threshold was severely compromised by a reduction in the number of TCRs. Costimulatory signals lowered the activation threshold to ∼1500 TCRs, thus making T cells more sensitive to antigenic stimulation.
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Cited by
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Klein, J., & Sato, A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009073431006 · Cited by 906
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
Demetriou, M., Granovsky, M., Quaggin, S., & Dennis, J. W. (2001) · Nature · doi:10.1038/35055582 · Cited by 901
CD28-mediated co-stimulation: a quantitative support for TCR signalling.
Acuto, O., & Michel, F. (2003) · Nature Reviews Immunology · doi:10.1038/nri1248 · Cited by 775
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Metadata
- Authors
- Viola, A., & Lanzavecchia, A.
- Venue
- Science
- Published
- 1996-07-05
- Volume
- 273
- Issue
- 5271
- Pages
- 104-106
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092643850
- Cited by
- 1,023
- References
- 0
- FWCI
- 32.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Viola, A., & Lanzavecchia, A. (1996). T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds. Science. https://doi.org/10.1126/science.273.5271.104
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