The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells
Open accessAbstract
Heat shock proteins (HSP), highly conserved across species, are generally viewed as intracellular proteins thought to serve protective functions against infection and cellular stress. Recently, we have reported the surprising finding that human and chlamydial HSP60, both present in human atheroma, can activate vascular cells and macrophages. However, the transmembrane signaling pathways by which extracellular HSP60 may activate cells remains unclear. CD14, the monocyte receptor for LPS, binds numerous microbial products and can mediate activation of monocytes/macrophages and endothelial cells, thus promoting the innate immune response. We show here that human HSP60 activates human PBMC and monocyte-derived macrophages through CD14 signaling and p38 mitogen-activated protein kinase, sharing this pathway with bacterial LPS. These findings provide further insight into the molecular mechanisms by which extracellular HSP may participate in atherosclerosis and other inflammatory disorders by activating the innate immune system.
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Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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Self-citationToll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
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Cited by
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
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Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Häcker, H., & Wagner, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103217200 · Cited by 805
Gao, B., & Tsan, M.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208742200 · Cited by 396
TLR signaling by tumor and immune cells: a double-edged sword
Huang, B., Zhao, J., Unkeless, J. C., Feng, Z. H., & Xiong, H. (2008) · Oncogene · doi:10.1038/sj.onc.1210904 · Cited by 377
Metadata
- Authors
- Kol, A., Lichtman, A. H., Finberg, R. W., Libby, P., & Kurt-Jones, E. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 164
- Issue
- 1
- Pages
- 13-17
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1899375067
- Cited by
- 554
- References
- 39
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kol, A., Lichtman, A. H., Finberg, R. W., Libby, P., & Kurt-Jones, E. A. (2000). Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.1.13
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