The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Cutting Edge: Cationic Antimicrobial Peptides Block the Binding of Lipopolysaccharide (LPS) to LPS Binding Protein
Open accessAbstract
We investigated the mechanism by which cationic antimicrobial peptides block the activation of macrophages by LPS. The initial step in LPS signaling is the transfer of LPS to CD14 by LPS binding protein (LBP). Because many cationic antimicrobial peptides bind LPS, we asked whether these peptides block the binding of LPS to LBP. Using an assay that measures the binding of LPS to immobilized LBP, we show for the first time that a variety of structurally diverse cationic antimicrobial peptides block the interaction of LPS with LBP. The relative ability of different cationic peptides to block the binding of LPS to LBP correlated with their ability to block LPS-induced TNF-α production by the RAW 264.7 macrophage cell line.
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Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Keys, J. R., Land vatter, S. W., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,288
Structure and Function of Lipopolysaccharide Binding Protein
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Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442
Cationic peptides: a new source of antibiotics
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Self-citationHuman CAP18: a novel antimicrobial lipopolysaccharide-binding protein
Larrick, J. W., Hirata, M., Balint, R. F., Lee, J., Zhong, J., & Wright, S. C. (1995) · Infection and Immunity · doi:10.1128/iai.63.4.1291-1297.1995 · Cited by 573
Recognition of Gram-negative bacteria and endotoxin by the innate immune system
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Antimicrobial peptides of vertebrates
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Cited by
Antimicrobial peptides: General overview and clinical implications in human health and disease
Guaní-Guerra, E., Santos-Mendoza, T., Lugo-Reyes, S. O., & Terán, L. M. (2010) · Clinical Immunology · doi:10.1016/j.clim.2009.12.004 · Cited by 549
Innate immune responses to infection
Tosi, M. F. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.05.036 · Cited by 391
Immunomodulatory Activities of Small Host Defense Peptides
Bowdish, D. M. E., Davidson, D. J., Scott, M. G., & Hancock, R. E. W. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1727-1732.2005 · Cited by 316
Self-citationNagaoka, I., Hirota, S., Niyonsaba, F., Hirata, M., Adachi, Y., Tamura, H., & Heumann, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3329 · Cited by 258
Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses
Brown, K. L., Poon, G. F. T., Birkenhead, D., Pena, O. M., Falsafi, R., Dahlgren, C., Karlsson, A., Bylund, J., Hancock, R. E. W., & Johnson, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002508 · Cited by 163
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Metadata
- Authors
- Scott, M. G., Vreugdenhil, A. C. E., Buurman, W. A., Hancock, R. E. W., & Gold, M. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01
- Volume
- 164
- Issue
- 2
- Pages
- 549-553
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1673257055
- Cited by
- 270
- References
- 24
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cutting Edge: Cationic Antimicrobial Peptides Block the Binding of Lipopolysaccharide (LPS) to LPS Binding Protein. https://app.cochat.ai/papers/10.4049/jimmunol.164.2.549
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- Scott, M. G., Vreugdenhil, A. C. E., Buurman, W. A., Hancock, R. E. W., & Gold, M. R. (2000). Cutting Edge: Cationic Antimicrobial Peptides Block the Binding of Lipopolysaccharide (LPS) to LPS Binding Protein. The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.2.549
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