The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Immunomodulatory Activities of Small Host Defense Peptides
Open accessAbstract
Recent studies have demonstrated that in addition to their antimicrobial activity, cationic host defense peptides, like the human cathelicidin LL-37, perform many activities relating to innate immunity, including the induction or modulation of chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components such as lipopolysaccharide (LPS) in vitro and in vivo. To investigate if these properties are shared by smaller peptides, two cathelicidin peptides derived from bovine neutrophils, the 13-mer indolicidin and Bac2A, a linear 12-amino-acid derivative of bactenecin, were compared to the 37-amino-acid peptide LL-37. Indolicidin, like LL-37, inhibited LPS-induced tumor necrosis factor alpha (TNF-α) secretion, even when added up to an hour after the addition of Escherichia coli O111:B4 LPS to the human macrophage/monocyte-like THP-1 cell line. In contrast, Bac2A demonstrated no significant antiendotoxin activity. At low concentrations, indolicidin and LL-37 acted synergistically to suppress LPS-induced production of TNF-α. Indolicidin was analogous to LL-37 in its ability to induce the production of the chemokine interleukin-8 (IL-8) in a human bronchial cell line, 16HBE14o − , but it was unable to induce production of IL-8 in THP-1 cells. In contrast, Bac2A was unable to induce IL-8 in either cell type. Conversely, Bac2A was chemotactic for THP-1 cells at concentrations between 10 and 100 μg/ml, while indolicidin and LL-37 were not chemotactic at these concentrations for THP-1 cells. This indicates that in addition to the potential for direct microbicidal activity, cationic host defense peptides may have diverse and complementary abilities to modulate the innate immune response.
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Cites
Atopic Dermatitis: Global Epidemiology and Risk Factors
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Activities of LL-37, a Cathelin-Associated Antimicrobial Peptide of Human Neutrophils
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Self-citationThe Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses
Scott, M. G., Davidson, D. J., Gold, M. R., Bowdish, D., & Hancock, R. E. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3883 · Cited by 713
Self-citationProduction of β-defensins by human airway epithelia
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Cited by
Antimicrobial host defence peptides: functions and clinical potential
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502
Self-citationLL-37, the only human member of the cathelicidin family of antimicrobial peptides
Dürr, U. H. N., Sudheendra, U. S., & Ramamoorthy, A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.03.030 · Cited by 1,049
Mookherjee, N., & Hancock, R. E. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6475-6 · Cited by 462
Self-citationAn anti-infective peptide that selectively modulates the innate immune response
Scott, M. G., Dullaghan, E., Mookherjee, N., Glavas, N., Waldbrook, M., Thompson, A., Wang, A., Lee, K., Doria, S., Hamill, P., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1288 · Cited by 403
Self-citationMechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
Raheem, N., & Straus, S. K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02866 · Cited by 369
Metadata
- Authors
- Bowdish, D. M. E., Davidson, D. J., Scott, M. G., & Hancock, R. E. W.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2005-05
- Volume
- 49
- Issue
- 5
- Pages
- 1727-1732
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2149168973
- Cited by
- 316
- References
- 39
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- green
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