Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

CpG motifs in bacterial DNA trigger direct B-cell activation

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The stress-activated protein kinase subfamily of c-Jun kinases

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CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

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Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA

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CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen

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CpG‐DNA‐specific activation of antigen‐presenting cells requires stress kinase activity and is preceded by non‐specific endocytosis and endosomal maturation

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Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: A new therapeutic option

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Differential immune effects mediated by Toll‐like receptors stimulation in precursor B‐cell acute lymphoblastic leukaemia

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Immune effects and therapeutic applications of CpG motifs in bacterial DNA

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Editorial: CpG Motifs to Modulate Innate and Adaptive Immune Responses

Vollmer, J. (2006) · International Reviews of Immunology · doi:10.1080/08830180600743115 · Cited by 29

Exogenous 8-oxo-7,8-dihydro-2′-deoxyguanosine: Biomedical properties, mechanisms of action, and therapeutic potential

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Multiple tandem copies of conserved gp41 epitopes incorporated in gag virus-like particles elicit systemic and mucosal antibodies in an optimized heterologous vector delivery regimen

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Suppression of B ‐cell activation and I g E , I g A , I g G 1 and I g G 4 production by mammalian telomeric oligonucleotides

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Stimulation of Innate Immune Responses by CpG Oligodeoxynucleotide in Newborn Lambs Can Reduce Bovine Herpesvirus-1 Shedding

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The Role of B Cells and Accessory Cells in the Neonatal Response to TI-2 Antigens

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The plasmid pcDNA3 differentially induces production of interferon-α and interleukin-6 in cultures of porcine leukocytes

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Toll-Like Receptor Ligation for the Induction of Regulatory B Cells

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G-Quadruplex Structure Improves the Immunostimulatory Effects of CpG Oligonucleotides

Hoshi, K., Yamazaki, T., Sugiyama, Y., Tsukakoshi, K., Tsugawa, W., Sode, K., & Ikebukuro, K. (2019) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0761 · Cited by 27

Single Stranded DNA Immune Modulators with Unmethylated CpG Motifs: Structure and Molecular Recognition by Toll-Like Receptor 9

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Gene Transfer to Mouse Heart and Skeletal Muscles Using a Minicircle Expressing Human Vascular Endothelial Growth Factor

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TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice

Godot, V., Tchérakian, C., Gil, L., Cervera-Marzal, I., Li, G., Cheng, L., Ortonne, N., Lelièvre, J., Pantaleo, G., Fenwick, C. W., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1009025 · Cited by 27

DNA vaccines for biodefence

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CpG oligonucleotides accelerate and boost the immune response elicited by AVA, the licensed anthrax vaccine

Klinman, D. M. (2006) · Expert Review of Vaccines · doi:10.1586/14760584.5.3.365 · Cited by 27

Porcine-specific CpG-oligodeoxynucleotide activates B-cells and increases the expression of MHC-II molecules on lymphocytes

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Current research on the immunostimulatory effects of CpG oligodeoxynucleotides in fish

Tassakka, A. C. M. A. R., & Sakai, M. (2005) · Aquaculture · doi:10.1016/j.aquaculture.2004.12.026 · Cited by 27

Cycling B-CLL cells are highly susceptible to inhibition of the proteasome

Bogner, C., Schneller, F., Hipp, S., Ringshausen, I., Peschel, C., & Decker, T. W. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(02)01076-7 · Cited by 27

CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines.

Rieger, R., & Kipps, T. J. (2003) · PubMed · Cited by 27

Oligodeoxynucleotides Containing CpG Motifs Induce Low Levels of TNF-α in Human B Lymphocytes: Possible Adjuvants for Th1 Responses

Bohle, B., Orel, L., Kraft, D., & Ebner, C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3743 · Cited by 27

Polymyxin B enhances ISS-mediated immune responses across multiple species

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The role of bacterial DNA containing CpG motifs in diseases

Zhou, J., & Deng, G. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr1220-748rrrrr · Cited by 26

Cp G inclusion in feed reduces sea lice, L epeophtheirus salmonis, numbers following re‐infection

Purcell, S. L., Friend, S. E., Covello, J. M., Donkin, A. W., Groman, D. B., Poley, J. D., & Fast, M. D. (2012) · Journal of Fish Diseases · doi:10.1111/jfd.12024 · Cited by 26

Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling

Yamazaki, K., Yamazaki, T., Taki, S., Miyake, K., Hayashi, T., Ochs, H. D., & Agematsu, K. (2010) · Clinical Immunology · doi:10.1016/j.clim.2009.12.013 · Cited by 26

CG sequence- and phosphorothioate backbone modification-dependent activation of the NF-κB-responsive gene expression by CpG-oligodeoxynucleotides in human RPMI 8226 B cells

Lee, K., Kim, D., & Kwon, H. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.022 · Cited by 26

Response of nitric oxide production to CpG oligodeoxynucleotides in turkey and chicken peripheral blood monocytes

He, H., Genovese, K. J., Lowry, V. K., Nisbet, D. J., & Kogut, M. H. (2006) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2006.00129.x · Cited by 26

In vivo oral administration effects of various oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to pseudorabies attenuated virus vaccine in newborn piglets

Linghua, Z., Xingshan, T., & Fengzhen, Z. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.10.058 · Cited by 26

Immunostimulation of bronchoalveolar lavage cells from recurrent airway obstruction-affected horses by different CpG-classes bound to gelatin nanoparticles

Klier, J., May, A., Fuchs, S. P., Schillinger, U., Plank, C., Winter, G., Gehlen, H., & Coester, C. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.07.009 · Cited by 25

Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice

Westwood, J. A., Haynes, N. M., Sharkey, J., McLaughlin, N. M., Pegram, H. J., Schwendener, R. A., Smyth, M. J., Darcy, P. K., & Kershaw, M. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2201 · Cited by 25

Neuroblastoma targeting by c-myb-selective antisense oligonucleotides entrapped in anti-GD2 immunoliposome: immune cell-mediated anti-tumor activities

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CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo

Hartmann, G., Marschner, A., Viveros, P. R., Stahl‐Hennig, C., Eisenblätter, M., Suh, Y.-S., Endres, S., Tenner‐Racz, K., Überla, K., Rácz, P., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.01.077 · Cited by 25

Inhibitory Oligonucleotides Block the Induction of AP-1 Transcription Factor by Stimulatory CpG Oligonucleotides in B Cells

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Requirements for Effective Inhibition of Immunostimulatory CpG Motifs by Neutralizing Motifs

Zhao, H., CHENG, S. H., & Yew, N. S. (2000) · Antisense and Nucleic Acid Drug Development · doi:10.1089/oli.1.2000.10.381 · Cited by 25

Monocyte-Mediated Inhibition of TLR9-Dependent IFN-α Induction in Plasmacytoid Dendritic Cells Questions Bacterial DNA as the Active Ingredient of Bacterial Lysates

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Potentiation of a Dendritic Cell Vaccine for Murine Renal Cell Carcinoma by CpG Oligonucleotides

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Blockade of TLR9 signaling in B cells impaired anti-dsDNA antibody production in mice induced by activated syngenic lymphocyte-derived DNA immunization

Chen, M., Zhang, W., Xu, W., Zhang, F., & Xiong, S. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.04.016 · Cited by 24

Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy

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Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α

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Drug Delivery Systems: Application of Liposomal Anti-Tumor Agents to Neuroectodermal Cancer Treatment

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CpG-oligodeoxynucleotide protects immune cells from γ-irradiation-induced cell death

Sohn, W., Lee, K., Choi, S. Y., Chung, E., Lee, Y., Kim, T. Y., Lee, S. K., Choe, Y.-K., Lee, J., Kim, D., et al. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.07.020 · Cited by 24

Toll-Like Receptor Signaling: Emerging Opportunities in Human Diseases and Medicine

Bhattacharjee, R. N., & Akira, S. (2005) · Current Immunology Reviews · doi:10.2174/1573395052952897 · Cited by 24

Immunotherapy with CpG DNA conjugated with T-cell epitope peptide of an allergenic Cry j 2 protein is useful for control of allergic conditions in mice

Suzuki, M., Ohta, N., Min, W., Matsumoto, T., Min, R., Zhang, X., Toida, K., & Murakami, S. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.08.010 · Cited by 23

Syk is indispensable for CpG-induced activation and differentiation of human B cells

Kremlitzka, M., Mácsik‐Valent, B., & Erdei, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1806-x · Cited by 22

Toll-like receptor agonists induce apoptosis in mouse B-cell lymphoma cells by altering NF-κB activation

Arunkumar, N., Liu, C., Hang, H., & Song, W. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.14 · Cited by 23

A specific CpG oligodeoxynucleotide induces protective antiviral responses against grass carp reovirus in grass carp Ctenopharyngodon idella

Su, H., Yuan, G., & Su, J. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.03.007 · Cited by 23

DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells and protects their suppressive potential from lipopolysaccharide effects: A potential role of adenosine

Sangiorgi, B., de Freitas, H. T., Schiavinato, J. L. D. S., Leão, V., Haddad, R., Orellana, M. D., Faça, V. M., Ferreira, G. A., Covas, D. T., Zago, M. A., et al. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.04.004 · Cited by 23

In vitro expansion of polyclonal T-cell subsets for adoptive immunotherapy by recombinant modified vaccinia Ankara

Rosa, C. L., Wang, Z., Lacey, S. F., Lalimarmo, M. M., Krishnan, A., Longmate, J., & Diamond, D. J. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2005.12.018 · Cited by 23

The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer.

Chen, K., Iribarren, P., Gong, W., & Wang, J. (2005) · PubMed · Cited by 23

CpG Oligodeoxynucleotide 2006 and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis

Gupta, S., Sane, S. A., Shakya, N., Vishwakarma, P., & Haq, W. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00137-11 · Cited by 22

Cross-Reactive Protection Against Influenza A Virus by a Topically Applied DNA Vaccine Encoding M Gene With Adjuvant

Ozaki, T., Yauchi, M., Xin, K.-Q., Hirahara, F., & Okuda, K. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.373 · Cited by 22

Impact of modifications of heterocyclic bases in CpG dinucleotides on their immune-modulatory activity

Vollmer, J., Weeratna, R. D., Jurk, M., Davis, H. L., Schetter, C., Wüllner, M., Wader, T., Liu, M., Kritzler, A., & Krieg, A. Μ. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0104034 · Cited by 22

ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA

Greiner-Tollersrud, O. K., Krausz, M., Boehler, V., Polyzou, A., Seidl, M., Spahiu, A., Abdullah, Z., Andryka, K., Dominick, F. I., Hübscher, K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114899 · Cited by 21

pH-sensitive PEG-coated hyper-branched β-d-glucan derivative as carrier for CpG oligodeoxynucleotide delivery

Su, Y., Li, X., Lam, K., & Cheung, P. C. K. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116621 · Cited by 21

Host-pathogen protein-nucleic acid interactions: A comprehensive review

Jain, A., Mittal, S., Tripathi, L. P., Nussinov, R., & Ahmad, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.001 · Cited by 23

Hierarchical recognition of CpG motifs expressed by immunostimulatory oligodeoxynucleotides

Klinman, D. M., & Currie, D. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02216.x · Cited by 21

Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses

Weigel, B. J., Panoskaltsis‐Mortari, A., Diers, M. D., García, M. M., Lees, C. J., Krieg, A. Μ., Chen, W., & Blazar, B. R. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.05.011 · Cited by 21

CpG oligodeoxynucleotides containing GACGTT motifs enhance the immune responses elicited by a goose parvovirus vaccine in ducks

Lee, J., Lin, Y.-M., Yen, T.-Y., Yang, W.-J., & Chu, C.-Y. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.09.072 · Cited by 21

TLR9-Independent Activation of B Lymphocytes by Bacterial DNA

Cortez‐Gonzalez, X., Pellicciotta, I., Gerloni, M., Wheeler, M. C., Castiglioni, P., Lenert, P. S., & Zanetti, M. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.253 · Cited by 21

Enhancement of gene transfer with recombinant adeno-associated virus (rAAV) vectors into primary B-cell chronic lymphocytic leukemia cells by CpG-oligodeoxynucleotides

Theiss, H. D., Kofler, D. M., Büning, H., Aldenhoff, A.-L., Kaess, B. M., Decker, T. W., Baumert, J., Hallek, M. J., & Wendtner, C. (2003) · Experimental Hematology · doi:10.1016/j.exphem.2003.09.010 · Cited by 22

CpG oligodeoxynucleotides stimulate cord blood mononuclear cells to produce immunoglobulins

Landers, C. D., & Bondada, S. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.04.013 · Cited by 21

Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells

Funaro, A., Gribaudo, G., Luganini, A., Ortolan, E., Buono, N. L., Vicenzi, E., Cassetta, L., Landolfo, S., Buick, R. J., Falciola, L., et al. (2008) · BMC Biotechnology · doi:10.1186/1472-6750-8-85 · Cited by 20

CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV

Zhao, H., Han, Q., Yang, A., Wang, Y., Wang, G., Lin, A., Wang, X., Yin, C., & Zhang, J. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62424 · Cited by 20

Human Beta Papillomavirus Type 8 E1 and E2 Proteins Suppress the Activation of the RIG-I-Like Receptor MDA5

Rattay, S., Hufbauer, M., Hagen, C., Putschli, B., Coch, C., Akgũl, B., & Hartmann, G. (2022) · Viruses · doi:10.3390/v14071361 · Cited by 19

Designing an immunocyte-targeting delivery system by use of beta-glucan

Miyamoto, N., Mochizuki, S., & Sakurai, K. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.11.053 · Cited by 22

Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-κB signal pathways

Chen, W., Wang, J., An, H., Zhou, J., Zhang, L., & Cao, X. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.11.006 · Cited by 20

Effect of Immunostimulatory CpG-Oligonucleotides in Chronic Lymphocytic Leukemia B Cells

Decker, T. W., & Peschel, C. (2001) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190109064586 · Cited by 20

Risk mitigation of immunogenicity: a key to personalized retinal gene therapy

Varin, J., Morival, C., Maillard, N., Adjali, O., & Cronin, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312818 · Cited by 19

DNA and RNA vaccines against tuberculosis: a scoping review of human and animal studies

Kazakova, A., Zhelnov, P., Sidorov, R. Y., Rogova, A. S., Vasileva, O., Ivanov, R. A., Reshetnikov, V. V., & Muslimov, A. R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1457327 · Cited by 21

Increased Toll-like receptor 9 expression by B cells from inflammatory bowel disease patients

Berkowitz, D., Peri, R., Lavy, A., & Kessel, A. (2013) · Human Immunology · doi:10.1016/j.humimm.2013.08.285 · Cited by 19

Differential Effects of P-Class Versus Other CpG Oligodeoxynucleotide Classes on the Impaired Innate Immunity of Plasmacytoid Dendritic Cells in HIV Type 1 Infection

Donhauser, N., Helm, M., Pritschet, K., Schuster, P., Ries, M., Korn, K., Vollmer, J., & Schmidt, B. (2010) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2008.0278 · Cited by 19

Bacterial DNA delays human eosinophil apoptosis

Ilmarinen, P., Hasala, H., Sareila, O., Moilanen, E., & Kankaanranta, H. (2008) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2008.11.012 · Cited by 19

Activation of Innate Immune Responses by a CpG Oligonucleotide Sequence Composed Entirely of Threose Nucleic Acid

Lange, M. J., Burke, D. H., & Chaput, J. C. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0751 · Cited by 19

Pharmaceutical Aspects and Clinical Evaluation of COVID-19 Vaccines

Hofman, K., Shenoy, G. N., Chak, V., & Balu‐Iyer, S. V. (2021) · Immunological Investigations · doi:10.1080/08820139.2021.1904977 · Cited by 20

Exploiting bacterial-origin immunostimulants for improved vaccination and immunotherapy: current insights and future directions

Wang, G., Wang, Y., & Ma, F. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01207-7 · Cited by 18

The autoreactivity of B cells in hereditary angioedema due to C1 inhibitor deficiency

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Immunostimulatory capacity of DNA vaccine vectors in porcine PBMC: a specific role for CpG-motifs?

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