Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

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CpG adjuvant enhances the mucosal immunogenicity and efficacy of aTreponema pallidumDNA vaccine in rabbits

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Technical Improvements in the Computational Target Search for Antisense Oligonucleotides

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The Arthritogenic and Immunostimulatory Properties of Phosphorothioate Oligodeoxynucleotides Rely on Synergy Between the Activities of the Nuclease-Resistant Backbone and CpG Motifs

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Newly identified CpG ODNs, M5-30 and M6-395, stimulate mouse immune cells to secrete TNF-α and enhance Th1-mediated immunity

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Immunomodulatory Effects of CpG Oligodeoxynucleotides on House Dust Mite-Induced Airway Inflammation in Mice

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Innate stimulation of B cells ex vivo enhances antibody secretion and identifies tumour-reactive antibodies from cancer patients

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Cervicovaginal microbiota disorder combined with the change of cytosine phosphate guanine motif- toll like receptor 9 axis was associated with cervical cancerization

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Effects of phosphodiester and phosphorothioate ODN2216 on leukotriene synthesis in human neutrophils and neutrophil apoptosis

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Class B CpG-ODN2006 is highly associated with IgM and antimicrobial peptide gene expression through TLR9 pathway in yellowtail Seriola lalandi

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All three classes of CpG ODNs up-regulate IP-10 gene in pigs

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Molecular Biology of the Host-Microbe Interaction in Periodontal Diseases

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Microbial Antigens Stimulate Metalloprotease-7 Secretion in Human B-Lymphocytes Using mTOR-Dependent and Independent Pathways

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TLR9 expression is related to immune activation but is impaired in individuals with chronic immune activation

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Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential

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Efficient computation of motif discovery on Intel Many Integrated Core (MIC) Architecture

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Radiotherapy Combined with Intralesional Immunostimulatory Agents for Soft Tissue Sarcomas

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A novel canine favored CpG oligodeoxynucleotide capable of enhancing the efficacy of an inactivated aluminum-adjuvanted rabies vaccine of dog use

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Kinetic Analysis of CpG-Induced Mouse B Cell Growth and Ig Production

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Distinct immunological activation profiles of dSLIM® and ProMune® depend on their different structural context

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Adjuvant Allergen Fusion Proteins as Novel Tools for the Treatment of Type I Allergies

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CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo

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Design of a New Fermented Beverage from Medicinal Plants and Organic Sugarcane Molasses via Lactic Fermentation

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Use of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies

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CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines

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In vitro immunization can elicit the expansion of diverse repertoire of B cells from peripheral blood mononuclear cells

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Human microsatellite DNA mimicking oligodeoxynucleotides down-regulate TLR9-dependent and -independent activation of human immune cells

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Mitigating the looming vaccine crisis: production and delivery of plasmid-based vaccines

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Immunostimulatory PyNTTTTGT Oligodeoxynucleotides: Structural Properties and Refinement of the Active Motif

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Antineoplastic effect of immunostimulatory DNA (CpG-ODN) in a murine C57-BL6/MB-49 transitional cell carcinoma model.

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DNA-based immunotherapy to treat atopic disease

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Structural requirements and applications of inhibitory oligodeoxyribonucleotides

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A newly identified CpG oligodeoxynucleotide motif that stimulates rainbow trout (Oncorhynchus mykiss) immune cells to produce immunomodulatory factors

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Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells

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Toll-like receptor interference in myeloid dendritic cells through head and neck cancer.

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Characterization of cooperative PS-oligo activation of human TLR9

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Oligonucleotide IMT504 induces an immunogenic phenotype and apoptosis in chronic lymphocytic leukemia cells.

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The newly identified CpG-N ODN208 protects mice from challenge with CpG-S ODN by decreasing TNF-α release

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Protective potential of CpG 1668 motif-harbouring plasmids againstMiamiensis avidus(Ciliophora: Scuticociliatida) infection in olive flounder (Paralichthys olivaceus)

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Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families

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Augmentation of HIV-1 Subtype C Vaccine Constructs Induced Immune Response in Mice by CpG Motif 1826-ODN

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The Role of Surface Ig Binding in the Activation of Human B Cells by Phosphorothioate Oligodeoxynucleotides

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BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists

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Peyer's patch-specific Lactobacillus reuteri strains increase extracellular microbial DNA and antimicrobial peptide expression in the mouse small intestine

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Unilineage monocytopoiesis in hematopoietic progenitor culture: switching cytokine treatment at all Mo developmental stages induces differentiation into dendritic cells

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Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines

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Functional studies of chronic lymphocytic leukemia B cells expressing β 2 -integrin type complement receptors CR3 and CR4

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Adjuvant Effects of Bacillus Calmette–Guerin DNA or CpG‐oligonucleotide in the Immune Response to Taenia solium Cysticercosis Vaccine in Porcine

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Mucosal SIgA Enhancement: Development of Safe and Effective Mucosal Adjuvants and Mucosal Antigen Delivery Vehicles

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Primary Allogeneic T-Cell Responses against Mantle Cell Lymphoma Antigen-Presenting Cells for Adoptive Immunotherapy after Stem Cell Transplantation

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pUC18-CpG Is an Effective Adjuvant for a Duck Tembusu Virus Inactivated Vaccine

Ren, X., Wang, X., Zhang, S., Gao, X., Fang, L., Wang, X., Lin, W., Jia, H., Guo, X., Xin, T., et al. (2020) · Viruses · doi:10.3390/v12020238 · Cited by 8

Therapeutic potential of CpG-ODN 1668 against scuticociliatosis in olive flounder (Paralichthys olivaceus)

Kang, Y. J., & Kim, K. H. (2014) · Aquaculture · doi:10.1016/j.aquaculture.2014.03.035 · Cited by 8

Cytosine-Phosphate-Guanine Oligodeoxynucleotides Containing GACGTT Motifs Enhance the Immune Responses Elicited by Keyhole Limpet Hemocyanin Antigen in Dairy Cattle

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How to Deal with Polarized Th2 Cells: Exploring the Achilles’ Heel

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Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities

Hanagata, N., Li, X., Chen, M., Li, J., & Hattori, S. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s152141 · Cited by 8

Oligonucleotide Therapeutics

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Intranasal immunization with HRSV prefusion F protein and CpG adjuvant elicits robust protective effects in mice

Ren, H., Li, H., Cao, L., Wang, Z., Zhou, Y., Guo, J., Zhang, Y., Liu, H., & Xu, W. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.09.071 · Cited by 7

Single-stranded oligodeoxynucleotides induce plant defence in Arabidopsis thaliana

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Structure-efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells

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Immunological effects of different types of synthetic CpG oligodeoxynucleotides on porcine cells

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Immunogenicity of inactivated formalin-killed Photobacterium damselae subsp. piscicida combined with Toll-like receptor 9 agonist in Cobia Rachycentron canadum

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Methoxyethyl-Modified Intercellular Adhesion Molecule-1 Antisense Phosphorothiateoligonucleotides Inhibit Allograft Rejection, Ischemic-Reperfusion Injury, and Cyclosporine-Induced Nephrotoxicity

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Interaction of CpG-oligodeoxynucleotides with Toll like receptor 9 induces apoptosis and modulates metaloproteinase-2 activity in human intestinal epithelium.

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Characterization of the TLR9-Activating Potential of LNA-Modified Antisense Oligonucleotides

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Aggregation and secondary loop structure of oligonucleotides do not determine their ability to inhibit TLR9

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Isolation of human myeloid dendritic cells from tumor tissue and peripheral blood.

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Effects of CpG Oligodeoxynucleotide 1826 on transforming growth factor-beta 1 and radiation-induced pulmonary fibrosis in mice

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Early development of the Toll-like receptor 9 agonist, PF-3512676, for the treatment of patients with advanced cancers

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The Immunomodulatory Functions of Various CpG Oligodeoxynucleotideson CEF Cells and H9N2 Subtype Avian Influenza Virus Vaccination

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Unmethylated CpG oligodeoxynucleotides activate head kidney leukocytes of Atlantic cod, Gadus morhua

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Oligonucleotide IMT504 Improves Glucose Metabolism and Controls Immune Cell Mediators in Female Diabetic NOD Mice

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Investigation of 13q14.3 deletion by cytogenetic analysis and FISH technique and miRNA-15a and miRNA-16-1 by real time PCR in chronic lymphocytic leukemia

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