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Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages
Open accessAbstract
Human alveolar macrophages (AMφ) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit the host by eliminating a supportive environment for bacterial growth. The present study compared AMφ apoptosis following infection by M. tuberculosis complex strains of differing virulence and by Mycobacterium kansasii. Avirulent or attenuated bacilli (M. tuberculosis H37Ra, Mycobacterium bovis bacillus Calmette-Guérin, and M. kansasii) induced significantly more AMφ apoptosis than virulent strains (M. tuberculosis H37Rv, Erdman, M. tuberculosis clinical isolate BMC 96.1, and M. bovis wild type). Increased apoptosis was not due to greater intracellular bacterial replication because virulent strains grew more rapidly in AMφ than attenuated strains despite causing less apoptosis. These findings suggest the existence of mycobacterial virulence determinants that modulate the apoptotic response of AMφ to intracellular infection and support the hypothesis that macrophage apoptosis contributes to innate host defense in tuberculosis.
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Cited by
Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin
Yuk, J.-M., Shin, D.-M., Lee, H.-M., Yang, C.-S., Jin, H. S., Kim, K.-K., Lee, Z.-W., Lee, S.-H., Kim, J.-M., & Jo, E.-K. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.08.004 · Cited by 787
Virulence factors of the Mycobacterium tuberculosis complex
Forrellad, M. A., Klepp, L. I., Gioffré, A., Sabio y García, J., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F. (2013) · Virulence · doi:10.4161/viru.22329 · Cited by 622
Briken, V., Porcelli, S. A., Besra, G. S., & Kremer, L. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04183.x · Cited by 425
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Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis
Cavalcanti, Y. V. N., Brelaz, M. C. A., Lemoine Neves, J. K. D. A., Ferraz, J. C., & Pereira, V. R. A. (2012) · Pulmonary Medicine · doi:10.1155/2012/745483 · Cited by 324
Metadata
- Authors
- Keane, J., Remold, H. G., & Kornfeld, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02
- Volume
- 164
- Issue
- 4
- Pages
- 2016-2020
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2162815684
- Cited by
- 542
- References
- 0
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Keane, J., Remold, H. G., & Kornfeld, H. (2000). Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages. The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.4.2016
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
