The DOI matches its Crossref record; 444 of the 444 references it cites were found in a registry or an index.
Virulence factors of the Mycobacterium tuberculosis complex
Open accessAbstract
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world.
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Cites
1 retracted
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Cited by
Barczak, A. K., Avraham, R., Singh, S., Luo, S. S., Zhang, W. R., Bray, M.-A., Hinman, A. E., Thompson, M., Nietupski, R. M., Golas, A., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006363 · Cited by 120
Mycobacteriaceae Mineralizes Micropolyethylene in Riverine Ecosystems.
Sun, X., Chen, Z., Kong, T., Chen, Z., Dong, Y., Kolton, M., Cao, Z., Zhang, X., Zhang, H., Liu, G., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c05346 · Cited by 46
A conserved membrane protein negatively regulates Mce1 complexes in mycobacteria
Chen, Y., Wang, Y., & Chng, S.-S. (2023) · Nature Communications · doi:10.1038/s41467-023-41578-y · Cited by 10
Metadata
- Authors
- Forrellad, M. A., Klepp, L. I., Gioffré, A., Sabio y García, J., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-01
- Volume
- 4
- Issue
- 1
- Pages
- 3-66
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- OpenAlex
- W2138402816
- Cited by
- 622
- References
- 444
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- Forrellad, M. A., Klepp, L. I., Gioffré, A., Sabio y García, J., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F. (2013). Virulence factors of the Mycobacterium tuberculosis complex. Virulence. https://doi.org/10.4161/viru.22329
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