The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent
Abstract
Experimental Schistosoma mansoni infections of mice lead to a dynamic type 2 cytokine-mediated pathological process. We have used IL-4-deficient, IL-13-deficient, and IL-4/13-deficient mice to dissect the role of these cytokines in the development of immune response and pathology following S. mansoni infection. We demonstrate that while both of these cytokines are necessary to develop a robust Th2 cell-driven, eosinophil-rich granuloma response, they also perform disparate functions that identify novel sites for therapeutic intervention. IL-13-deficient mice demonstrated significantly enhanced survival following infection, which correlated with reduced hepatic fibrosis. In contrast, increased mortality was manifest in IL-4-deficient and IL-4/13-deficient mice, and this correlated with hepatocyte damage and intestinal pathology. Therefore, we demonstrate that during a dynamic type 2 cytokine disease process IL-13 is detrimental to survival following infection, whereas IL-4 is beneficial.
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Cites
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Cited by
Cellular and molecular mechanisms of fibrosis
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Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
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Metadata
- Authors
- Fallon, P. G., Richardson, E. J., McKenzie, G. J., & McKenzie, A. N. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 164
- Issue
- 5
- Pages
- 2585-2591
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2153250595
- Cited by
- 403
- References
- 43
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent. https://app.cochat.ai/papers/10.4049/jimmunol.164.5.2585
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- Fallon, P. G., Richardson, E. J., McKenzie, G. J., & McKenzie, A. N. J. (2000). Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent. The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.5.2585
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