The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
CD8+ CTL from Lungs of Mycobacterium tuberculosis -Infected Mice Express Perforin In Vivo and Lyse Infected Macrophages
Abstract
CD8+ T lymphocytes have been implicated in the protective immune response against human and murine tuberculosis. However, the functional role that this cell subset plays during the resolution of infection remains controversial. In this study, we demonstrate the presence of Mycobacterium tuberculosis-specific CD8+ CTL in the lungs and lung-draining lymph nodes of mice infected with M. tuberculosis via the aerosol or i.v. route. These cells expressed perforin in vivo and specifically recognized and lysed M. tuberculosis-infected macrophages in a perforin-dependent manner after a short period of in vitro restimulation. The efficiency of lysis of infected macrophages was dependent upon the time allowed for interaction between macrophage and M. tuberculosis bacilli. Recognition of infected targets by CD8+ CTL was β2-microglobulin and MHC class I dependent and was not CD1d restricted. The presented data indicate that CD8+ T cells contribute to the protective immune response during M. tuberculosis infection by exerting cytotoxic function and lysing infected macrophages.
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Citations
Cites
Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells
Slifka, M. K., Rodriguez, F., & Whitton, J. L. (1999) · Nature · doi:10.1038/43454 · Cited by 255
Lewinsohn, D. M., Alderson, M. R., Briden, A. L., Riddell, S. R., Reed, S. G., & Grabstein, K. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.10.1633 · Cited by 165
Cited by
Lockhart, E., Green, A. M., & Flynn, J. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4662 · Cited by 767
Self-citationPersistent bacterial infections: the interface of the pathogen and the host immune system
Monack, D. M., Mueller, A., & Falkow, S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro955 · Cited by 572
Tuberculosis: a problem with persistence
Stewart, G. R., Robertson, B. D., & Young, D. B. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro749 · Cited by 386
An RNA-Based Vaccine Platform for Use against Mycobacterium tuberculosis
Larsen, S. E., Erasmus, J. H., Reese, V. A., Pecor, T., Archer, J., Kandahar, A., Hsu, F.-C., Nicholes, K., Reed, S. G., Baldwin, S. L., et al. (2023) · Vaccines · doi:10.3390/vaccines11010130 · Cited by 66
Metadata
- Authors
- Serbina, N. V., Liu, C.-C., Scanga, C. A., & Flynn, J. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-07-01
- Volume
- 165
- Issue
- 1
- Pages
- 353-363
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2101377929
- Cited by
- 164
- References
- 2
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Serbina, N. V., Liu, C.-C., Scanga, C. A., & Flynn, J. L. (2000). CD8+ CTL from Lungs of Mycobacterium tuberculosis -Infected Mice Express Perforin In Vivo and Lyse Infected Macrophages. The Journal of Immunology. https://doi.org/10.4049/jimmunol.165.1.353
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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