Characterization of Human CD8+ T Cells Reactive with Mycobacterium tuberculosis–infected Antigen-presenting Cells

Lewinsohn, David M.; Alderson, Mark R.; Briden, Andria L.; Riddell, Stanley R.; Reed, Steven G.; Grabstein, Kenneth H.

doi:10.1084/jem.187.10.1633

Cited by 165Tuberculosis Research and EpidemiologyImmunotherapy and Immune ResponsesT-cell and B-cell Immunology

Characterization of Human CD8+ T Cells Reactive with Mycobacterium tuberculosis–infected Antigen-presenting Cells

Open access

Lewinsohn, David M., Alderson, Mark R., Briden, Andria L., Riddell, Stanley R., Reed, Steven G., Grabstein, Kenneth H.·1998·The Journal of Experimental Medicine

DOI 10.1084/jem.187.10.1633PMC PMC2212289

Open this paper in CoChat — free account

Abstract

Previous studies in murine models, including those using the β2 microglobulin knockout mouse, have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). At present, little is understood about these cells in the human immune response to tuberculosis. This report demonstrates the existence of human Mtb-reactive CD8+ T cells. These cells are present preferentially in persons infected with Mtb and produce interferon γ in response to stimulation with Mtb-infected target cells. Recognition of Mtb-infected cells by these CD8+ T cells is restricted neither by the major histocompatibility complex (MHC) class I A, B, or C alleles nor by CD1, although it is inhibited by anti–MHC class I antibody. The Mtb-specific CD8+ T cells recognize an antigen which is generated in the proteasome, but which does not require transport through the Golgi-ER. The data suggest the possible use of nonpolymorphic MHC class Ib antigen presenting structures other than CD1.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1084/jem.187.10.1633

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Melanoma cells and antigen-presenting cells can both display HLA-I and HLA-II peptides of bacterial origin.
“We demonstrate that bacterial HLA-I and HLA-II peptides can be presented by both antigen-presenting cells (as has previously been shown25–28) and by melanoma cells”
From Identification of bacteria-derived HLA-bound peptides in melanoma (2021) · cites this paper as [28]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., & Bloom, B. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2249 · Cited by 2,468 · see citing works
Proliferating dendritic cell progenitors in human blood.
Romani, N., Grüner, S., Brang, D., Kämpgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M., & Schuler, G. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.83 · Cited by 1,841 · see citing works
Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice
Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schrelber, R., Mak, T. W., & Bloom, B. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90001-2 · Cited by 1,678 · see citing works
Recognition of a lipid antigen by CD1-restricted αβ+ T cells
Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 977 · see citing works
The global tuberculosis situation and the new control strategy of the World Health Organization
Kochi, A. (1991) · Tubercle · doi:10.1016/0041-3879(91)90017-m · Cited by 849 · see citing works
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.
Flynn, J. L., Goldstein, M. M., Triebold, K. J., Koller, B. H., & Bloom, B. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12013 · Cited by 793 · see citing works
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
Huygen, K., Content, J., Denis, O., Montgomery, D. L., Yawman, A. M., Deck, R. R., DeWitt, C. M., Orme, I. M., Baldwin, S. L., D'Souza, C. D., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-893 · Cited by 628 · see citing works
Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V. (1993) · Nature · doi:10.1038/361359a0 · Cited by 615 · see citing works
Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.
Kovacsovics-Bankowski, M., Clark, K., D, B. B. M., & Rock, K. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.4942 · Cited by 590 · see citing works
CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen
Porcelli, S. A., Morita, C. T., & Brenner, M. B. (1992) · Nature · doi:10.1038/360593a0 · Cited by 572 · see citing works
Differential Effects of Cytolytic T Cell Subsets on Intracellular Infection
Stenger, S., Mazzaccaro, R. J., Uyemura, K., Cho, S., Barnes, P. F., Rosat, J., Sette, A., Brenner, M. B., Porcelli, S. A., Bloom, B. R., et al. (1997) · Science · doi:10.1126/science.276.5319.1684 · Cited by 518 · see citing works
Vaccination against tuberculosis by DNA injection
Tascon, R. E., Colston, M. J., Ragno, S., Stavropoulos, E., Gregory, D., & Lowrie, D. B. (1996) · Nature Medicine · doi:10.1038/nm0896-888 · Cited by 506 · see citing works
Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.
Molloy, A., Laochumroonvorapong, P., & Kaplan, G. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1499 · Cited by 501 · see citing works
Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.
Xu, S., Cooper, A. M., Sturgill-Koszycki, S., van Heyningen, T., Chatterjee, D., Orme, I. M., Allen, P. M., & Russell, D. G. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2568 · Cited by 359 · see citing works
Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.
Sousa, C. R. E., & Germain, R. N. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.3.841 · Cited by 296 · see citing works
Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins
Peña, S. V., Hanson, D. A., Carr, B., Goralski, T. J., & Krensky, A. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2680 · Cited by 256 · see citing works
CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family
Beckman, E. M., Melián, A., Behar, S. M., Sieling, P. A., Chatterjee, D., Furlong, S. T., Matsumoto, R., Rosat, J., Modlin, R. L., & Porcelli, S. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.7.2795 · Cited by 209 · see citing works
H-2M3 presents a listeria monocytogenes peptide to cytotoxic T lymphocytes
Pamer, E. G., Wang, C.-R., Flaherty, L. A., Lindahl, K. F., & Bevan, M. J. (1992) · Cell · doi:10.1016/0092-8674(92)90097-v · Cited by 199 · see citing works
The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms
Cooper, A. M., D'Souza, C. D., Frank, A. A., & Orme, I. M. (1997) · Infection and Immunity · doi:10.1128/iai.65.4.1317-1320.1997 · Cited by 163 · see citing works
Identification of an H2-M3-Restricted Listeria Epitope: Implications for Antigen Presentation by M3
Lenz, L. L., Dere, B., & Bevan, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80310-6 · Cited by 143 · see citing works
Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice
Laochumroonvorapong, P., Wang, J., Liu, C. C., Ye, W., Moreira, A. L., Elkon, K. B., Freedman, V. H., & Kaplan, G. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.127-132.1997 · Cited by 138 · see citing works
Role of T Cell Subsets in Immunity against Intracellular Bacteria: Experimental Infections of Knock-Out Mice with Listeria monocytogenes and Mycobacterium bovis BCG
Kaufmann, S. H. E., & Ladel, C. H. (1994) · Immunobiology · doi:10.1016/s0171-2985(11)80457-2 · Cited by 125 · see citing works
Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection
Zhu, X. W., Venkataprasad, N., Thangaraj, H. S., Hill, M. K., Singh, M., Iványi, J., & Vordermeier, H. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.12.5921 · Cited by 121 · see citing works
A Listeria monocytogenes Pentapeptide Is Presented to Cytolytic T Lymphocytes by the H2-M3 MHC Class Ib Molecule
Gulden, P. H., Fischer, P. R., Sherman, N. E., Wang, W., Engelhard, V. H., Shabanowitz, J., Hunt, D. F., & Pamer, E. G. (1996) · Immunity · doi:10.1016/s1074-7613(00)80311-8 · Cited by 110 · see citing works
Human dendritic Langerhans cells generated in vitro from CD34+ progenitors can prime naive CD4+ T cells and process soluble antigen
Caux, C., Massacrier, C., Dezutter‐Dambuyant, C., Vanbervliet, B., Jacquet, C., Schmitt, D., & Banchereau, J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.11.5427 · Cited by 103 · see citing works
Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development
Threlkeld, S. C., Wentworth, P. A., Kalams, S. A., Wilkes, B. M., Ruhl, D. J., Keogh, E. A., Sidney, J., Southwood, S., Walker, B. D., & Sette, A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1648 · Cited by 100 · see citing works
Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65.
Silva, C. A., Silva, M. F., Pietro, R. C. L. R., & Lowrie, D. B. (1994) · PubMed Central · Cited by 93 · see citing works
Evidence for the expression of non-HLA-A,-B,-C class I genes in the human fetal liver
Houlihan, J. M., Biro, P. A., Fergar-Payne, A., Simpson, K. L., & Holmes, C. H. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.2.668 · Cited by 76 · see citing works
Antigen recognition by MHC-incompatible cells of a human mismatched chimera.
Roncarolo, M., Yssel, H., Touraine, J. L., Bacchetta, R., Gebuhrer, L., de Vries, J. E., & Spits, H. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.6.2139 · Cited by 72 · see citing works
Evidence for a superantigen in human tuberculosis
Ohmen, J. D., Barnes, P. F., Grimm, C. L., Bloom, B. R., & Modlin, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90007-8 · Cited by 71 · see citing works
HLA non-A,B,C class I genes: Their structure and expression
Heinrichs, H., & Orr, H. T. (1990) · Immunologic Research · doi:10.1007/bf02935526 · Cited by 60 · see citing works
Processing and presentation of mycobacterial antigens: implications for the development of a new improved vaccine for tuberculosis control
Orme, I. M. (1991) · Tubercle · doi:10.1016/0041-3879(91)90048-w · Cited by 10 · see citing works

Flagged first, then by citations

1 of the 33 references couldn’t be matched to a known paper.

Sorted by citations

Immunology of tuberculosis.
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144 · see citing works
How can immunology contribute to the control of tuberculosis?
Kaufmann, S. H. E. (2001) · Nature reviews. Immunology · doi:10.1038/35095558 · Cited by 727 · see citing works
Innate Immunity toMycobacterium tuberculosis
van Crevel, R., Ottenhoff, T. H. M., & van der Meer, J. W. M. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.294-309.2002 · Cited by 602 · see citing works
Individual RD1‐region genes are required for export of ESAT‐6/CFP‐10 and for virulence of Mycobacterium tuberculosis
Guinn, K. M., Hickey, M. J., Mathur, S. K., Zakel, K. L., Grotzke, J. E., Lewinsohn, D. M., Smith, S., & Sherman, D. R. (2004) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03844.x · Cited by 508 · see citing works
Self-citation
Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.
Caruso, A. M., Serbina, N. V., Klein, E. C., Triebold, K. J., Bloom, B. R., & Flynn, J. L. (1999) · PubMed · Cited by 489 · see citing works
Identification of bacteria-derived HLA-bound peptides in melanoma
Kalaora, S., Nagler, A., Nejman, D., Alon, M., Barbolin, C., Barnea, E., Ketelaars, S. L. C., Cheng, K., Vervier, K., Shental, N., et al. (2021) · Nature · doi:10.1038/s41586-021-03368-8 · Cited by 457 · see citing works
Mice Deficient in CD4 T Cells Have Only Transiently Diminished Levels of IFN-γ, Yet Succumb to Tuberculosis
Caruso, A. M., Serbina, N. V., Klein, E. C., Triebold, K. J., Bloom, B. R., & Flynn, J. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5407 · Cited by 418 · see citing works
Susceptibility of Mice Deficient in CD1D or TAP1 to Infection with Mycobacterium tuberculosis
Behar, S. M., Dascher, C. C., Grusby, M. J., Wang, C.-R., & Brenner, M. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1973 · Cited by 374 · see citing works
Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2
Scanga, C. A., Mohan, V. P., Yu, K., Joseph, H. M., Tanaka, K. E., Chan, J., & Flynn, J. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.347 · Cited by 351 · see citing works
Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis -Infected Individuals: Associations with Clinical Disease State and Effect of Treatment
Pathan, A. A., Wilkinson, K. A., Klenerman, P., McShane, H., Davidson, R. N., Pasvol, G., Hill, A. V. S., & Lalvani, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5217 · Cited by 350 · see citing works
Immunology of tuberculosis and implications in vaccine development
Flynn, J. L. (2003) · Tuberculosis · doi:10.1016/j.tube.2003.08.010 · Cited by 304 · see citing works
Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice
Sousa, A. O., Mazzaccaro, R. J., Russell, R. G., Lee, F. K., Turner, O. C., Hong, S., Kaer, L. V., & Bloom, B. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4204 · Cited by 275 · see citing works
Serum cytokine profiles and their correlations with disease activity in Takayasu's arteritis
Park, M., Lee, S., Park, Y.-B., & Lee, S. K. (2005) · Lara D. Veeken · doi:10.1093/rheumatology/kei266 · Cited by 249 · see citing works
ESX-1 and phthiocerol dimycocerosates of <i>Mycobacterium tuberculosis</i> act in concert to cause phagosomal rupture and host cell apoptosis
Augenstreich, J., Arbues, A., Simeone, R., Haanappel, E., Wegener, A., Sayes, F., Le Chevalier, F., Chalut, C., Malaga, W., Guilhot, C., et al. (2017) · Cellular Microbiology · doi:10.1111/cmi.12726 · Cited by 240 · see citing works
HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells
Heinzel, A. S., Grotzke, J. E., Lines, R. A., Lewinsohn, D. A., McNabb, A. L., Streblow, D. N., Braud, V. M., Grieser, H. J., Belisle, J. T., & Lewinsohn, D. M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020609 · Cited by 213 · see citing works
Self-citation
Increased Production of Interleukin 4 by CD4 + and CD8 + T Cells from Patients with Tuberculosis Is Related to the Presence of Pulmonary Cavities
van Crevel, R., Karyadi, E., Preyers, F., Leenders, M., Kullberg, B. J., Nelwan, R. H. H., & van der Meer, J. W. M. (2000) · The Journal of Infectious Diseases · doi:10.1086/315325 · Cited by 212 · see citing works
Confrontation between Intracellular Bacteria and the Immune System
Schaible, U. E., Collins, H., & Kaufmann, S. H. E. (1998) · Advances in immunology · doi:10.1016/s0065-2776(08)60405-8 · Cited by 182 · see citing works
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis
Cho, S., Mehra, V. L., Thoma-Uszynski, S., Stenger, S., Serbina, N. V., Mazzaccaro, R. J., Flynn, J. L., Barnes, P. F., Southwood, S., Celis, E., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210391497 · Cited by 180 · see citing works
A New Recombinant Bacille Calmette‐Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis‐Specific Immunity in Human Volunteers
Hoft, D. F., Blazevic, A., Abate, G., Hanekom, W. A., Kaplan, G., Soler, J., Weichold, F., Geiter, L., SADOFF, J. C., & Horwitz, M. A. (2008) · The Journal of Infectious Diseases · doi:10.1086/592450 · Cited by 177 · see citing works
Mycobacterium tuberculosis-Specific CD8+ T Cells and Their Role in Immunity
Woodworth, J. S., & Behar, S. M. (2006) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v26.i4.30 · Cited by 175 · see citing works
Early Emergence of CD8+T Cells Primed for Production of Type 1 Cytokines in the Lungs ofMycobacterium tuberculosis-Infected Mice
Serbina, N. V., & Flynn, J. L. (1999) · Infection and Immunity · doi:10.1128/iai.67.8.3980-3988.1999 · Cited by 174 · see citing works
CD4+ T Cells Are Required for the Development of Cytotoxic CD8+ T Cells During Mycobacterium tuberculosis Infection
Serbina, N. V., Lazarevic, V., & Flynn, J. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6991 · Cited by 174 · see citing works
Identification of a Human HLA-E-Restricted CD8+ T Cell Subset in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain Ty21a Typhoid Vaccine
Salerno-Gonçalves, R., Fernández-Viña, M., Lewinsohn, D. M., & Sztein, M. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5852 · Cited by 165 · see citing works
Self-citation
CD8+ CTL from Lungs of Mycobacterium tuberculosis -Infected Mice Express Perforin In Vivo and Lyse Infected Macrophages
Serbina, N. V., Liu, C., Scanga, C. A., & Flynn, J. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.353 · Cited by 164 · see citing works
Immunodominant Tuberculosis CD8 Antigens Preferentially Restricted by HLA-B
Lewinsohn, D. A., Winata, E., Swarbrick, G. M., Tanner, K. E., Cook, M. S., Null, M. D., Cansler, M. E., Sette, A., Sidney, J., & Lewinsohn, D. M. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030127 · Cited by 154 · see citing works
Self-citation
Molecular Characterization and Human T-Cell Responses to a Member of a Novel Mycobacterium tuberculosis mtb39 Gene Family
Dillon, D. C., Alderson, M. R., Day, C. H., Lewinsohn, D. M., Coler, R. N., Bement, T., Campos‐Neto, A., Skeiky, Y. A. W., Orme, I. M., Roberts, A. D., et al. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2941-2950.1999 · Cited by 159 · see citing works
Self-citation
T cell mediated immunity to Mycobacterium tuberculosis
Stenger, S., & Modlin, R. L. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80015-0 · Cited by 156 · see citing works
Mycobacterium tuberculosis –specific CD8+ T Cells Preferentially Recognize Heavily Infected Cells
Lewinsohn, D. A., Heinzel, A. S., Gardner, J. M., Zhu, L., Alderson, M. R., & Lewinsohn, D. M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200306-837oc · Cited by 151 · see citing works
Self-citation
HIV-Host Interactions: Implications for Vaccine Design
Haynes, B. F., Shaw, G. M., Korber, B., Kelsoe, G. H., Sodroski, J., Hahn, B. H., Borrow, P., & McMichael, A. J. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.02.002 · Cited by 150 · see citing works
Tuberculosis vaccine development: goals, immunological design, and evaluation
Hoft, D. F. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61036-3 · Cited by 140 · see citing works
CD8 + T Cells Participate in the Memory Immune Response to Mycobacterium tuberculosis
Serbina, N. V., & Flynn, J. L. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4320-4328.2001 · Cited by 130 · see citing works
CD8+ T Cells in Tuberculosis
Lazarevic, V., & Flynn, J. L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2204027 · Cited by 129 · see citing works
Protective Immunity againstMycobacterium tuberculosisInduced by Dendritic Cells Pulsed with both CD8+- and CD4+-T-Cell Epitopes from Antigen 85A
McShane, H., Behboudi, S., Goonetilleke, N. P., Brookes, R. H., & Hill, A. V. S. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1623-1626.2002 · Cited by 123 · see citing works
Expression Cloning of an Immunodominant Family of Mycobacterium tuberculosis Antigens Using Human Cd4+ T Cells
Alderson, M. R., Bement, T., Day, C. H., Zhu, L., Molesh, D. A., Skeiky, Y. A. W., Coler, R. N., Lewinsohn, D. M., Reed, S. G., & Dillon, D. C. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.551 · Cited by 119 · see citing works
Self-citation
Immune responses in tuberculosis
Flynn, J. L., & Ernst, J. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00116-3 · Cited by 118 · see citing works
The role of dendritic cells in Mycobacterium tuberculosis infection
Mihret, A. (2012) · Virulence · doi:10.4161/viru.22586 · Cited by 115 · see citing works
In Situ Production of Gamma Interferon, Interleukin-4, and Tumor Necrosis Factor Alpha mRNA in Human Lung Tuberculous Granulomas
Fenhalls, G., Wong, A., Bezuidenhout, J., van Helden, P. D., Bardin, P. G., & Lukey, P. T. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2827-2836.2000 · Cited by 114 · see citing works
Human CD8+ CTL Specific for the Mycobacterial Major Secreted Antigen 85A
Smith, S. M., Brookes, R. H., Klein, M. R., Malin, A. S., Lukey, P. T., King, A. S., Ogg, G. S., Hill, A. V. S., & Dockrell, H. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.12.7088 · Cited by 113 · see citing works
Role of CD8+ T lymphocytes in control of Mycobacterium tuberculosis infection
Grotzke, J. E., & Lewinsohn, D. M. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.03.001 · Cited by 110 · see citing works
Self-citation
Phagocytosis: the convoluted way from nutrition to adaptive immunity
Desjardins, M., Houde, M., & Gagnon, E. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00319.x · Cited by 107 · see citing works
Antigen-Specific CD8+ T Cells and Protective Immunity to Tuberculosis
Behar, S. M. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6111-1_8 · Cited by 102 · see citing works
Mycobacterium tuberculosis-Reactive CD8+ T Lymphocytes: The Relative Contribution of Classical Versus Nonclassical HLA Restriction
Lewinsohn, D. M., Briden, A. L., Reed, S. G., Grabstein, K. H., & Alderson, M. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.925 · Cited by 102 · see citing works
Self-citation
Interleukin-7 or Interleukin-15 Enhances Survival ofMycobacterium tuberculosis-Infected Mice
Maeurer, M. J., Trinder, P. K. E., Hommel, G., Walter, W., Freitag, K., Atkins, D., & Störkel, S. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2962-2970.2000 · Cited by 99 · see citing works
The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle
Grotzke, J. E., Harriff, M. J., Siler, A. C., Nolt, D. L., Delepine, J., Lewinsohn, D. A., & Lewinsohn, D. M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000374 · Cited by 97 · see citing works
Self-citation
Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
Joosten, S. A., Sullivan, L. C., & Ottenhoff, T. H. M. (2016) · Journal of Immunology Research · doi:10.1155/2016/2695396 · Cited by 96 · see citing works
T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion
Shepherd, F. R., & McLaren, J. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176144 · Cited by 97 · see citing works
Alternate Class I MHC Antigen Processing Is Inhibited by Toll-Like Receptor Signaling Pathogen-Associated Molecular Patterns: Mycobacterium tuberculosis 19-kDa Lipoprotein, CpG DNA, and Lipopolysaccharide
Tobian, A. A. R., Potter, N., Ramachandra, L., Pai, R. K., Convery, M., Boom, W. H., & Harding, C. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1413 · Cited by 96 · see citing works
MHC molecules and microbial antigen processing in phagosomes
Ramachandra, L., Simmons, D. P., & Harding, C. V. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.001 · Cited by 95 · see citing works
Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria
Balin, S. J., Pellegrini, M. A., Klechevsky, E., Won, S. T., Weiss, D. I., Choi, A. W., Hakimian, J. K., Lu, J. N., Ochoa, M. T., Bloom, B. R., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat7668 · Cited by 95 · see citing works
Characterization of HumanMycobacterium bovisBacille Calmette-Guerin-Reactive CD8+T Cells
Smith, S. M., Malin, A. S., Pauline, T., Lukey, Atkinson, S. E., Content, J., Huygen, K., & Dockrell, H. M. (1999) · Infection and Immunity · doi:10.1128/iai.67.10.5223-5230.1999 · Cited by 95 · see citing works
A recombinant adenovirus expressing immunodominant TB antigens can significantly enhance BCG-induced human immunity
Hoft, D. F., Blazevic, A., Stanley, J., Landry, B., Sizemore, D. R., Kpamegan, E. P., Gearhart, J., Scott, A. J., Kik, S. V., Pau, M. G., et al. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.048 · Cited by 94 · see citing works
Classically Restricted Human CD8+ T Lymphocytes Derived from Mycobacterium tuberculosis -Infected Cells: Definition of Antigenic Specificity
Lewinsohn, D. M., Zhu, L., Madison, V. J., Dillon, D. C., Fling, S. P., Reed, S. G., Grabstein, K. H., & Alderson, M. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.439 · Cited by 94 · see citing works
Self-citation
Polymorphism of human CD1 genes
Han, M., Hannick, L. I., DiBrino, M., & Robinson, M. A. (1999) · Tissue Antigens · doi:10.1034/j.1399-0039.1999.540202.x · Cited by 94 · see citing works
T cell responses to bacterial infection
Kerksiek, K. M., & Pamer, E. G. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80067-3 · Cited by 91 · see citing works
Co-dependents: MR1-restricted MAIT cells and their antimicrobial function
Gold, M. C., & Lewinsohn, D. M. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2918 · Cited by 88 · see citing works
Self-citation
Characterization of a Mycobacterium tuberculosis Peptide That Is Recognized by Human CD4+ and CD8+ T Cells in the Context of Multiple HLA Alleles
Shams, H., Klucar, P., Weis, S. E., Lalvani, A., Moonan, P. K., Safi, H., Wizel, B., Ewer, K., Nepom, G. T., Lewinsohn, D. M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1966 · Cited by 86 · see citing works
Self-citation
Phenotypical and Functional Analysis of Memory and Effector Human CD8 T Cells Specific for Mycobacterial Antigens
Caccamo, N., Meraviglia, S., Mendola, C. L., Guggino, G., Dieli, F., & Salerno, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1780 · Cited by 84 · see citing works
Identification of committed NK cell progenitors in adult murine bone marrow
Rosmaraki, E. E., Douagi, I., Roth, C., Colucci, F., Cumano, A., & Santo, J. P. D. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200106)31:6 · Cited by 361 · see citing works
Identification of a Promiscuous T-Cell Epitope inMycobacterium tuberculosisMce Proteins
Panigada, M., Sturniolo, T., Besozzi, G., Boccieri, M. G., Sinigaglia, F., Grassi, G. G., & Grassi, F. (2002) · Infection and Immunity · doi:10.1128/iai.70.1.79-85.2002 · Cited by 82 · see citing works
Human pathogen subversion of antigen presentation
Brodsky, F. M., Lem, L., Solache, A., & Bennett, E. M. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01294.x · Cited by 77 · see citing works
Cutting Edge: Major CD8 T Cell Response to Live Bacillus Calmette-Guerin Is Mediated by CD1 Molecules
Kawashima, T., Norose, Y., Watanabe, Y., Enomoto, Y., Narazaki, H., Watari, E., Tanaka, S., Takahashi, H., Yano, I., Brenner, M. B., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5345 · Cited by 77 · see citing works
Antigens for CD4 and CD8 T Cells in TuberculosisPreprint
Arlehamn, C. S. L., Lewinsohn, D. M., Sette, A., & Lewinsohn, D. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018465 · Cited by 74 · see citing works
Self-citation
Human CD8+T Cells Specific forMycobacterium tuberculosisSecreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia
Smith, S. M., Klein, M. R., Malin, A. S., Sillah, J. S., Huygen, K., Andersen, P. L., McAdam, K. P. W. J., & Dockrell, H. M. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.7144-7148.2000 · Cited by 74 · see citing works
Mycobacterium tuberculosis and TLR2 Agonists Inhibit Induction of Type I IFN and Class I MHC Antigen Cross Processing by TLR9
Simmons, D. P., Canaday, D. H., Liu, Y., Li, Q., Huang, A. Y.-C., Boom, W. H., & Harding, C. V. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904005 · Cited by 73 · see citing works
CD8+ T Cells Provide an Immunologic Signature of Tuberculosis in Young Children
Lancioni, C., Nyendak, M. R., Kiguli, S., Zalwango, S. K., Mori, T., Mayanja‐Kizza, H., Balyejusa, S., Null, M. D., Baseke, J., Mulindwa, D., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201107-1355oc · Cited by 72 · see citing works
Self-citation
Mycobacterium lepraeInfection in Monocyte-Derived Dendritic Cells and Its Influence on Antigen-Presenting Function
Hashimoto, K., Maeda, Y., Kimura, H. J., Suzuki, K., Masuda, A., Matsuoka, M., & Makino, M. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.5167-5176.2002 · Cited by 72 · see citing works
Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice
Patankar, Y. R., Sutiwisesak, R., Boyce, S., Lai, R., Arlehamn, C. S. L., Sette, A., & Behar, S. M. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0217-6 · Cited by 69 · see citing works
Mycobacterium tuberculosis Growth Control by Lung Macrophages and CD8 Cells from Patient Contacts
Carranza, C., Juárez, E., Torres, M., Ellner, J. J., Sada, E., & Schwander, S. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200503-411oc · Cited by 66 · see citing works
Secreted Proteins from Mycobacterium tuberculosis Gain Access to the Cytosolic MHC Class-I Antigen-Processing Pathway
Lewinsohn, D. M., Grotzke, J. E., Heinzel, A. S., Zhu, L., Ovendale, P. J., Johnson, M., & Alderson, M. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.437 · Cited by 66 · see citing works
Self-citation
Cytotoxic T cell responses to intracellular pathogens
Stenger, S., & Modlin, R. L. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80123-4 · Cited by 66 · see citing works
Overexpression of IL-15 In Vivo Enhances Protection Against Mycobacterium bovis Bacillus Calmette-Guerin Infection Via Augmentation of NK and T Cytotoxic 1 Responses
Umemura, M., Nishimura, H., Hirose, K., Matsuguchi, T., & Yoshikai, Y. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.946 · Cited by 65 · see citing works
Generation of CD8+T-Cell Responses toMycobacterium bovisand Mycobacterial Antigen in Experimental Bovine Tuberculosis
Liébana, E., Girvin, R. M., Welsh, M., Neill, S. D., & Pollock, J. M. (1999) · Infection and Immunity · doi:10.1128/iai.67.3.1034-1044.1999 · Cited by 65 · see citing works
A novel TB vaccine; towards a strategy based on our understanding of BCG failure
Agger, E. M., & Andersen, P. L. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00447-4 · Cited by 64 · see citing works
The human macrophage cell line U937 as an in vitro model for selective evaluation of mycobacterial antigen‐specific cytotoxic T‐cell function
Passmore, J.-A. S., Lukey, P. T., & Ress, S. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01164.x · Cited by 64 · see citing works
CD8+ T Cell Subsets and Chronic Obstructive Pulmonary Disease
Kemeny, D. M., Vyas, B., Vukmanovic‐Stejic, M., Thomas, M. J., Noble, A., Loh, L., & O'Connor, B. J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.supplement_1.10 · Cited by 64 · see citing works
Recent advances in our understanding of human host responses to tuberculosis
Schluger, N. W. (2001) · Respiratory Research · doi:10.1186/rr53 · Cited by 61 · see citing works
Induction of M3-Restricted Cytotoxic T Lymphocyte Responses by N-Formylated Peptides Derived from Mycobacterium tuberculosis
Chun, T., Serbina, N. V., Nolt, D. L., Wang, B., Chiu, N. M., Flynn, J. L., & Wang, C.-R. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.10.1213 · Cited by 63 · see citing works
Antigen Load Governs the Differential Priming of CD8 T Cells in Response to the Bacille Calmette Guérin Vaccine or Mycobacterium tuberculosis Infection
Ryan, A. A., Nambiar, J. K., Wozniak, T. M., Roediger, B., Shklovskaya, E., Britton, W. J., Groth, B. F. D. S., & Triccas, J. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801694 · Cited by 61 · see citing works
Cytolytic T Cells in the Immune Response to Mycobacterium tuberculosis
Stenger, S. (2001) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540110026584 · Cited by 61 · see citing works
Phagocytic antigen processing and effects of microbial products on antigen processing and T‐cell responses
Ramachandra, L., Chu, R. S., Askew, D. S., Noss, E. H., Canaday, D. H., Potter, N., Johnsen, A. K., Krieg, A. Μ., Nedrud, J. G., Boom, W. H., et al. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01295.x · Cited by 55 · see citing works
Decreased IFN- γ and increased IL-4 production by human CD8+ T cells in response toMycobacterium tuberculosis in tuberculosis patients
Smith, S. M., Klein, M. R., Malin, A. S., Sillah, J., Mcadam, K. P. W. J., & Dockrell, H. M. (2002) · Tuberculosis · doi:10.1054/tube.2001.0317 · Cited by 55 · see citing works
Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion
Cai, Y., Wang, Y., Shi, C., Dai, Y., Li, F., Xu, Y., Zhang, P., Kong, F., Deng, G., Wen, Z., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211777 · Cited by 54 · see citing works
The unconventional role of HLA-E: The road less traveled
Grant, E. J., Nguyen, A., Lobos, C. A., Szeto, C. W., Chatzileontiadou, D. S. M., & Gras, S. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.02.011 · Cited by 54 · see citing works
Defining putative T cell epitopes from PE and PPE families of proteins of Mycobacterium tuberculosis with vaccine potential
Chaitra, M. G., Hariharaputran, S., Chandra, N. R., Shaila, M. S., & Nayak, R. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.08.046 · Cited by 53 · see citing works
Role of CD8+ T cells in mycobacterial infections
Smith, S. M., & Dockrell, H. M. (2000) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2000.00936.x · Cited by 53 · see citing works
Contribution of CD8+T Cells to Gamma Interferon Production in Human Tuberculosis
Shams, H., Wizel, B., Weis, S. E., Samten, B., & Barnes, P. F. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.3497-3501.2001 · Cited by 53 · see citing works
M. tuberculosis: immunology and vaccination
Rook, G. A. W., Seah, G. T., & Ustianowski, A. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.17305370 · Cited by 52 · see citing works
Suppressor of cytokine signaling-3 is affected in T-cells from tuberculosisTB patients
Jacobsen, M., Repsilber, D., Kleinsteuber, K., Gutschmidt, A., Schommer-Leitner, S., Black, G. F., Walzl, G., & Kaufmann, S. H. E. (2010) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2010.03326.x · Cited by 51 · see citing works
Escape from the Phagosome: The Explanation for MHC-I Processing of Mycobacterial Antigens?
Harriff, M. J., Purdy, G. E., & Lewinsohn, D. M. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00040 · Cited by 46 · see citing works
Self-citation
Identification by Mass Spectrometry of CD8+-T-CellMycobacterium tuberculosisEpitopes within the Rv0341 Gene Product
Flyer, D. C., Ramakrishna, V., Miller, C., Myers, H. E., McDaniel, M., Root, K. E., Flournoy, C., Engelhard, V. H., Canaday, D. H., Marto, J. A., et al. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.2926-2932.2002 · Cited by 47 · see citing works
Identification of an Immunomodulating Agent fromMycobacterium leprae
Maeda, Y., Mukai, T., Spencer, J. S., & Makino, M. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.2744-2750.2005 · Cited by 47 · see citing works
Ectopic Activation of Mycobacterium tuberculosis -Specific CD4+ T Cells in Lungs of CCR7−/− Mice
Olmos, S., Stukes, S. A., & Ernst, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901230 · Cited by 46 · see citing works
Protective effect of DNA immunization against mycobacterial infection is associated with the early emergence of interferon-gamma (IFN-γ)-secreting lymphocytes
Kamath, A. T., Groat, N. L., Bean, A. G. D., & Britton, W. J. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01240.x · Cited by 45 · see citing works
Clonal Expansion of CD8+ Effector T Cells in Childhood Tuberculosis
Jacobsen, M., Detjen, A., Mueller, H., Gutschmidt, A., Schommer-Leitner, S., Wahn, U., Magdorf, K., & Kaufmann, S. H. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1331 · Cited by 44 · see citing works
Secreted Immunodominant Mycobacterium tuberculosis Antigens Are Processed by the Cytosolic Pathway
Grotzke, J. E., Siler, A. C., Lewinsohn, D. A., & Lewinsohn, D. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000801 · Cited by 42 · see citing works
Self-citation
Mycobacterium tuberculosis
(2004) · American Journal of Transplantation · doi:10.1111/j.1600-6135.2004.00724.x · Cited by 39 · see citing works
CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis
Salao, K., Jiang, L., Li, H., Tsai, V., Husaini, Y., Curmi, P., Brown, L., Brown, D., & Breit, S. (2016) · Biology Open · doi:10.1242/bio.018119 · Cited by 32 · see citing works
Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope
Feng, C. G., Demangel, C., Kamath, A. T., Macdonald, M., & Britton, W. J. (2001) · International Immunology · doi:10.1093/intimm/13.4.451 · Cited by 37 · see citing works
Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine
Nyendak, M. R., Swarbrick, G. M., Duncan, A., Cansler, M. E., Winata, E., Hokey, D. A., Evans, T., Barker, L. F., Blatner, G. L., SADOFF, J. C., et al. (2016) · Scientific Reports · doi:10.1038/srep36355 · Cited by 36 · see citing works
Self-citation
HLA‐B*35–Restricted CD8 T Cell Epitopes in the Antigen 85 Complex ofMycobacterium tuberculosis
Klein, M. R., Smith, S. M., Hammond, A. S., Ogg, G. S., King, A. S., Vekemans, J., Jaye, A., Lukey, P. T., & McAdam, K. P. W. J. (2001) · The Journal of Infectious Diseases · doi:10.1086/319267 · Cited by 36 · see citing works

Summary
Lewinsohn, M., Alderson, M. R., Briden, A. L., Riddell, S. R., Reed, S. G., & Grabstein, K. H. (2013)
Self-citation
Nonclassical MHC Ib-restricted CD8+ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection
Shang, S., Siddiqui, S., Bian, Y., Zhao, J., & Wang, C.-R. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005688 · Cited by 27 · see citing works
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis
Cho, S., Mehra, V. L., Thoma-Uszynski, S., Stenger, S., Serbina, N. V., Mazzaccaro, R. J., Flynn, J. L., Barnes, P. F., Southwood, S., Celis, E., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210391497 · Cited by 180 · see citing works
Nonclassical MHC Ib-restricted CD8+ T cells recognize Mycobacterium tuberculosis-derived protein antigens and contribute to protection against infection (MPF6P.744)
Shang, S., Bian, Y., Siddiqui, S., Zhao, J., & Wang, C.-R. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.192.supp.195.13
Human cytolytic and interferon γ-secreting CD8 + T lymphocytes specific for Mycobacterium tuberculosis
Lalvani, A., Brookes, R. H., Wilkinson, R. J., Malin, A. S., Pathan, A. A., Andersen, P. L., Dockrell, H. M., Pasvol, G., & Hill, A. V. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.270 · Cited by 361 · see citing works

Authors: Lewinsohn, D. M., Alderson, M. R., Briden, A. L., Riddell, S. R., Reed, S. G., & Grabstein, K. H.
Affiliations: Infectious Disease Research Institute (US)
Corresponding author: Lewinsohn, David M.
ORCID: Lewinsohn, David M.
Alderson, Mark R.
Riddell, Stanley R.
Reed, Steven G.
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1998-05-18
Volume: 187
Issue: 10
Pages: 1633-1640
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.187.10.1633
PMC: PMC2212289
OpenAlex: W2111354206
Cited by: 165
References: 33
Citations by year: 2026: 2 · 2025: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 6
FWCI: 16.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (5T32 HL-07287, T32HL007287)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: CD8+ T cells, Mycobacterium tuberculosis, tuberculosis, interferon-gamma, MHC class I restriction, MHC class Ib, antigen presentation, human immune response
MeSH terms: Acetylcysteine, Amino Acid Sequence, Animals, Chloroquine, Humans, Lymphocyte Cooperation, Molecular Sequence Data, Mycobacterium tuberculosis, Tuberculosis, Cysteine Proteinase Inhibitors, Antigen Presentation, CD8-Positive T-Lymphocytes, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Characterization of Human CD8+ T Cells Reactive with Mycobacterium tuberculosis–infected Antigen-presenting Cells

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks