Cited by 217Chemokine receptors and signalingHIV Research and TreatmentHIV/AIDS drug development and treatment

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The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse

Unutmaz, Derya, Xiang, Wenkai, Sunshine, Mary Jean, Campbell, Jim, Butcher, Eugene, Littman, Dan R·2000·The Journal of Immunology

DOI 10.4049/jimmunol.165.6.3284

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Abstract

Chemokines play necessary and important roles in regulating the trafficking of lymphocytes to intra- or interlymphoid tissues as well as to sites of inflammation. The complex migratory patterns of lymphoid lineage cells is governed by subset-specific expression of chemokine receptors and their access to specific ligands. Several chemokine receptors and chemokine receptor-like orphan receptors also serve, in conjunction with CD4, as coreceptors for infection by human and simian immunodeficiency viruses (HIV and SIV). Here we show that the expression pattern of Bonzo/STRL33, an orphan SIV/HIV coreceptor, is highly restricted to the memory subset of T cells and is up-regulated upon stimulation of these cells with IL-2 or IL-15. Both the pattern and the regulation of Bonzo expression closely paralleled that of CC family chemokine receptors CCR5 or CCR6 and inversely correlated with CXCR4 expression. However, in striking contrast to CCR5, Bonzo expression was not down-modulated by PMA or mitogen stimulation of T cells. Targeted replacement of the Bonzo gene with a gene encoding green fluorescent protein in mice revealed that the expression and cytokine regulation of mouse Bonzo are comparable to those of its human counterpart. The similar expression and regulation patterns of Bonzo and the HIV coreceptor CCR5 may have implications for understanding the role of HIV/SIV receptors in viral evolution and pathogenesis.

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Authors: Unutmaz, D., Xiang, W., Sunshine, M. J., Campbell, J., Butcher, E., & Littman, D. R.
Affiliations: Howard Hughes Medical Institute (US)
Stanford Medicine (US)
ORCID: Unutmaz, Derya
Sunshine, Mary Jean
Butcher, Eugene
Littman, Dan R
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2000-09
Volume: 165
Issue: 6
Pages: 3284-3292
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.165.6.3284
OpenAlex: W2137869737
Cited by: 217
References: 59
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 9 · 2013: 13 · 2012: 10
FWCI: 3.39
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u19ai036606-02)
National Institute of Allergy and Infectious Diseases (AI36606, AI 33856, R01AI033856)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: CCR5, CCR6, CXCR4, HIV co-receptor, chemokine receptors, memory T cells, interleukin-2, IL-15, gene expression regulation, viral evolution
MeSH terms: Receptors, CXCR6, Animals, Cells, Cultured, Gene Expression Regulation, Genetic Markers, Genetic Vectors, Humans, Infant, Interphase, Leukocytes, Mononuclear, Luminescent Proteins, Lymphocyte Activation, Membrane Proteins, Mice, Inbred C57BL, Protein Processing, Post-Translational, Receptors, Virus, T-Lymphocytes, Lentivirus, Cytokines, Conserved Sequence, Sequence Deletion, Receptors, Cytokine, Mice, Knockout, Gene Targeting, Receptors, Chemokine, Receptors, CCR5, Receptors, G-Protein-Coupled, Green Fluorescent Proteins, Mice

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The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse

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