The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse
Abstract
Chemokines play necessary and important roles in regulating the trafficking of lymphocytes to intra- or interlymphoid tissues as well as to sites of inflammation. The complex migratory patterns of lymphoid lineage cells is governed by subset-specific expression of chemokine receptors and their access to specific ligands. Several chemokine receptors and chemokine receptor-like orphan receptors also serve, in conjunction with CD4, as coreceptors for infection by human and simian immunodeficiency viruses (HIV and SIV). Here we show that the expression pattern of Bonzo/STRL33, an orphan SIV/HIV coreceptor, is highly restricted to the memory subset of T cells and is up-regulated upon stimulation of these cells with IL-2 or IL-15. Both the pattern and the regulation of Bonzo expression closely paralleled that of CC family chemokine receptors CCR5 or CCR6 and inversely correlated with CXCR4 expression. However, in striking contrast to CCR5, Bonzo expression was not down-modulated by PMA or mitogen stimulation of T cells. Targeted replacement of the Bonzo gene with a gene encoding green fluorescent protein in mice revealed that the expression and cytokine regulation of mouse Bonzo are comparable to those of its human counterpart. The similar expression and regulation patterns of Bonzo and the HIV coreceptor CCR5 may have implications for understanding the role of HIV/SIV receptors in viral evolution and pathogenesis.
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“Meningeal γδ17 T cells were also enriched for Tcrgv6 transcripts encoding the TCR-Vγ4 chain (Garman nomenclature, Extended Data Fig. 2a), which characterizes a subset of fetal thymus-derived γδ17 T cells9.”
From Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons (2020) · cites this paper as [9]
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Metadata
- Authors
- Unutmaz, D., Xiang, W., Sunshine, M. J., Campbell, J., Butcher, E., & Littman, D. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Stanford Medicine (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 165
- Issue
- 6
- Pages
- 3284-3292
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2137869737
- Cited by
- 217
- References
- 59
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 9 · 2013: 13 · 2012: 10
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u19ai036606-02)
- National Institute of Allergy and Infectious Diseases (AI36606, AI 33856, R01AI033856)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- CCR5, CCR6, CXCR4, HIV co-receptor, chemokine receptors, memory T cells, interleukin-2, IL-15, gene expression regulation, viral evolution
- MeSH terms
- Receptors, CXCR6, Animals, Cells, Cultured, Gene Expression Regulation, Genetic Markers, Genetic Vectors, Humans, Infant, Interphase, Leukocytes, Mononuclear, Luminescent Proteins, Lymphocyte Activation, Membrane Proteins, Mice, Inbred C57BL, Protein Processing, Post-Translational, Receptors, Virus, T-Lymphocytes, Lentivirus, Cytokines, Conserved Sequence, Sequence Deletion, Receptors, Cytokine, Mice, Knockout, Gene Targeting, Receptors, Chemokine, Receptors, CCR5, Receptors, G-Protein-Coupled, Green Fluorescent Proteins, Mice
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