The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ATP Mediates Calcium Signaling Between Astrocytes and Microglial Cells: Modulation by IFN-γ
Open accessAbstract
Calcium-mediated intercellular communication is a mechanism by which astrocytes communicate with each other and modulate the activity of adjacent cells, including neurons and oligodendrocytes. We have investigated whether microglia, the immune effector cells involved in several diseases of the CNS, are actively involved in this communication network. To address this issue, we analyzed calcium dynamics in fura-2-loaded cocultures of astrocytes and microglia under physiological conditions and in the presence of the inflammatory cytokine IFN-γ. The intracellular calcium increases in astrocytes, occurring spontaneously or as a result of mechanical or bradykinin stimulation, induced the release of ATP, which, in turn, was responsible for triggering a delayed calcium response in microglial cells. Repeated stimulations of microglial cells by astrocyte-released ATP activated P2X7 purinergic receptor on microglial cells and greatly increased membrane permeability, eventually leading to microglial apoptosis. IFN-γ increased ATP release and potentiated the P2X7-mediated cytolytic effect. This is the first study showing that ATP mediates a form of calcium signaling between astrocytes and microglia. This mechanism of intercellular communication may be involved in controlling the number and function of microglial cells under pathophysiologic CNS conditions.
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Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110
Cited by
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Role of Microglia in Central Nervous System Infections
Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.942-964.2004 · Cited by 723
Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia
Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., & Verderio, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7268 · Cited by 596
Self-citationThe impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572
Metadata
- Authors
- Verderio, C., & Matteoli, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-05
- Volume
- 166
- Issue
- 10
- Pages
- 6383-6391
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1541085684
- Cited by
- 242
- References
- 2
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Verderio, C., & Matteoli, M. (2001). ATP Mediates Calcium Signaling Between Astrocytes and Microglial Cells: Modulation by IFN-γ. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.10.6383
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